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E3 ligase ligands bind ubiquitin ligases such as cereblon and von Hippel-Lindau (VHL) in degrader design. In a degrader, they anchor the ligase end of the molecule. E3 ubiquitin ligases transfer ubiquitin to substrate proteins and mark them for degradation by the proteasome. Thalidomide and its analogs bind cereblon (CRBN), a substrate receptor of a cullin-based E3 ligase complex identified as their direct target in 2010. The category includes cereblon ligands such as thalidomide fluoride and TD-106, and VHL ligands such as VL285 and VH032-cyclopropane-F. These ligands are used to build proteolysis-targeting chimeras (PROTACs) and to study how ligases are recruited to new substrates.
CRBN ligand-526 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be employed in the development of PROTACs (proteolysis targeting chimeras) by linking it to a target protein ligand through a suitable linker. Research applications include targeted protein degradation studies, enabling the exploration of novel therapeutic strategies in various disease models.
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CRBN ligand-610 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein to target proteins. This compound can be conjugated to a target protein ligand through a linker, enabling the development of PROTACs (proteolysis-targeting chimeras) for targeted protein degradation applications. It is a valuable tool for researchers studying ubiquitin-proteasome pathway modulation and targeted therapeutics.
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CRBN ligand-258 is a ligand specifically designed for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of cereblon to target proteins, enabling the formation of targeted protein degradation chimeras (PROTACs) when linked with an appropriate target ligand. It serves as a valuable tool in drug discovery and development by promoting the ubiquitin-proteasome pathway for selective protein degradation.
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CRBN ligand-360 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated with a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). It is suitable for applications in targeted protein degradation research and studies involving ubiquitin-proteasome system modulation.
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CRBN ligand-347 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It effectively recruits the cereblon protein, facilitating the targeted degradation of proteins through the proteasome pathway. This compound is commonly employed in PROTAC (proteolysis-targeting chimera) applications, allowing researchers to develop bifunctional molecules that selectively degrade specific target proteins in various biological contexts.
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CRBN ligand-316 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound is particularly useful in the development of Proteolysis Targeting Chimeras (PROTACs) by linking to target protein ligands through a suitable linker. Its application in targeted protein degradation makes it a valuable tool in chemical biology and therapeutic research.
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CRBN ligand-752 is a ligand specifically designed for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). Its application in targeted protein degradation research offers valuable insights into cell signaling and disease mechanisms.
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CRBN ligand-362 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound serves as a crucial component in the development of PROTACs (proteolysis-targeting chimeras), enabling targeted protein degradation. Its application is vital for research into targeted therapies and the modulation of protein levels in cellular contexts.
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CRBN ligand-768 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker to create a Proteolysis Targeting Chimera (PROTAC). It serves as a valuable tool in the study of targeted protein degradation and has potential applications in drug discovery and therapeutic development.
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CRBN ligand-705 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound effectively recruits the CRBN protein and can be utilized to create peptide-hybrid PROTACs when linked to a target protein ligand through a suitable linker. Its application in protein degradation research provides valuable insights into targeted protein modulation and therapeutic development.
CRBN ligand-353 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be utilized in the design of PROTACs (Proteolysis Targeting Chimeras) by covalently linking it to a target protein ligand via a suitable linker. It is valuable in studies focused on targeted protein degradation and modulation of cellular pathways mediated by ubiquitination.
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CRBN ligand-378 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to target protein ligands through a linker, enabling the formation of proteolysis-targeting chimeras (PROTACs). It is valuable for research applications focused on targeted protein degradation and modulation of cellular pathways.
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CRBN ligand-599 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be utilized in the design of proteolysis-targeting chimeras (PROTACs) by linking it to specific target protein ligands through a suitable linker. Its applications include studying targeted protein degradation mechanisms and potential therapeutic interventions in protein homeostasis-related diseases.
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CRBN ligand-595 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a proteolysis-targeting chimera (PROTAC). CRBN ligand-595 is valuable for studies in targeted protein degradation and E3 ligase-mediated ubiquitination pathways.
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CRBN ligand-622 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a proteolysis-targeting chimera (PROTAC). Its use in research enables the selective degradation of specific proteins, thereby aiding investigations into protein regulation and therapeutic applications.
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CRBN ligand-787 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to specific target proteins. This compound can be utilized in the development of proteolysis-targeting chimeras (PROTACs) by linking it to a ligand for the target protein, enabling targeted degradation via the ubiquitin-proteasome system. CRBN ligand-787 is valuable in research applications focused on protein regulation and degradation mechanisms.
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Phenyl-glutarimide 4'-oxyacetic acid is a carboxylic acid-functionalized ligand targeting proteins involved in PROTAC (Proteolysis Targeting Chimeras) pathways. This compound exhibits enhanced hydrolytic stability and efficacy when interacting with PROTACs, making it a valuable tool for researchers developing PROTAC deactivators. Its distinct binding properties facilitate investigations into protein degradation mechanisms and associated signaling pathways.
CRBN ligand-720 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to generate a PROTAC (proteolysis-targeting chimeras), enabling targeted protein degradation. It is useful in research applications involving ubiquitin-proteasome system modulation and has potential implications in therapeutic discovery.
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CRBN ligand-210 is an E3 ubiquitin ligase cereblon (CRBN) ligand that facilitates the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker, thereby enabling the construction of a PROTAC. Such applications are valuable for targeted protein degradation studies, offering insights into protein function and regulation in various biological contexts.
CRBN ligand-537 is a specific ligand for the E3 ubiquitin ligase, cereblon (CRBN). It facilitates the recruitment of CRBN to target proteins, enabling targeted protein degradation through the formation of proteolysis-targeting chimeras (PROTACs). This compound is valuable in research applications focused on investigating protein ubiquitination and degradation pathways.
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CRBN ligand-365 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling targeted protein degradation via the ubiquitin-proteasome system. This compound serves as a crucial component for the development of PROTACs (Proteolysis Targeting Chimeras) by facilitating the recruitment of CRBN to a specific target protein. This functionality makes CRBN ligand-365 a valuable tool for investigating protein homeostasis and therapeutic interventions in various biological pathways and diseases.
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CRBN ligand-693 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of CRBN to specific target proteins, enabling the formation of PROTACs (proteolysis-targeting chimeras). It is suitable for use in research applications focused on targeted protein degradation and the modulation of protein levels within various cellular pathways.
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CRBN ligand-433 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of the CRBN protein, enabling the design of Proteolysis Targeting Chimeras (PROTACs) for targeted protein degradation. This compound is valuable for research applications focused on understanding cellular protein regulation and developing novel therapeutic strategies.
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CRBN ligand-299 serves as an E3 ubiquitin ligase ligand that selectively recruits the cereblon (CRBN) protein. This compound can be utilized to conjugate with target protein ligands through a linker, facilitating the development of proteolysis-targeting chimeras (PROTACs) for targeted protein degradation studies. As such, it is valuable for research focused on modulating protein levels and studying cellular processes influenced by ubiquitination pathways.
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CRBN ligand-306 is a ligand designed for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized to connect with target protein ligands through a linker, forming a proteolysis-targeting chimera (PROTAC). Its applications include targeted protein degradation research, offering a pathway for studying and modulating protein levels in cellular systems.
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