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E3 Ligase Ligands

E3 ligase ligands bind ubiquitin ligases such as cereblon and von Hippel-Lindau (VHL) in degrader design. In a degrader, they anchor the ligase end of the molecule. E3 ubiquitin ligases transfer ubiquitin to substrate proteins and mark them for degradation by the proteasome. Thalidomide and its analogs bind cereblon (CRBN), a substrate receptor of a cullin-based E3 ligase complex identified as their direct target in 2010. The category includes cereblon ligands such as thalidomide fluoride and TD-106, and VHL ligands such as VL285 and VH032-cyclopropane-F. These ligands are used to build proteolysis-targeting chimeras (PROTACs) and to study how ligases are recruited to new substrates.

Cat. No.

A80965

CAS No.

2623101-33-5

CRBN ligand-890

CRBN ligand-890 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of CRBN for targeted protein degradation. This compound can be conjugated with a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis targeting chimera) for selective degradation of proteins of interest. Its application in research includes investigations into protein homeostasis and therapeutic strategies for diseases linked to aberrant protein levels.

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$95.00

50 mg

$150.00

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Cat. No.

A80966

CAS No.

2925095-48-1

CRBN ligand-630

CRBN ligand-630 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be effectively coupled with target protein ligands via a linker to create a proteolysis-targeting chimera (PROTAC). CRBN ligand-630 is valuable in studies of targeted protein degradation and the modulation of cellular processes through ubiquitin-mediated pathways.

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Cat. No.

A80967

CAS No.

2925095-60-7

CRBN ligand-346

CRBN ligand-346 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated with a target protein ligand through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimera). CRBN ligand-346 is instrumental in studies involving targeted protein degradation, offering insights into mechanisms of action in cellular processes and potential therapeutic applications.

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Cat. No.

A80968

CAS No.

2925097-82-9

CRBN ligand-736

CRBN ligand-736 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be utilized in the construction of PROTACs (Proteolysis Targeting Chimeras) by linking it to a target protein ligand through a linker. CRBN ligand-736 serves as a valuable tool for studies involving targeted protein degradation and therapeutic development in cancer and other diseases.

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Cat. No.

A80969

CAS No.

2925085-03-4

CRBN ligand-586

CRBN ligand-586 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein in targeted protein degradation applications. This compound can be conjugated with a target-specific ligand through a suitable linker to create a PROTAC, enabling the degradation of proteins of interest. CRBN ligand-586 is valuable for research in the fields of cancer biology and therapeutic development.

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Cat. No.

A80970

CAS No.

2925095-33-4

CRBN ligand-490

CRBN ligand-490 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the cereblon protein. This compound can be conjugated with a target protein ligand through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimera). CRBN ligand-490 is valuable for studies in targeted protein degradation and therapeutic research applications related to modulating cellular protein levels.

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Cat. No.

A80971

CAS No.

2925099-93-8

CRBN ligand-479

CRBN ligand-479 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of CRBN to target proteins. This compound can be conjugated to a specific target protein ligand through a linker, enabling the formation of a proteolysis-targeting chimeric (PROTAC) molecule. CRBN ligand-479 is essential for studies in targeted protein degradation and has applications in drug discovery and development.

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Cat. No.

A80972

CAS No.

2925079-15-6

CRBN ligand-457

CRBN ligand-457 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound serves as a valuable tool for the development of PROTACs by linking CRBN to target protein ligands through a suitable linker. Its utility in targeted protein degradation research makes it an essential reagent for studies in drug discovery and cellular biology.

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Cat. No.

A80974

CAS No.

2766178-46-3

CRBN ligand-658

CRBN ligand-658 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN in cellular systems. It is designed for the development of proteolysis-targeting chimeras (PROTACs) by linking to target protein ligands via a suitable linker. This compound is useful in investigating ubiquitin-proteasome pathway mechanisms and advancing targeted protein degradation research.

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Cat. No.

A80975

CAS No.

2925082-45-5

CRBN ligand-513

CRBN ligand-513 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of the CRBN protein. This compound can be utilized in the development of proteolysis-targeting chimeras (PROTACs) by linking it to a target protein ligand through a suitable linker. Its primary application lies in targeted protein degradation studies, contributing to research on cellular regulation and therapeutic development.

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Cat. No.

A80976

CAS No.

1799506-31-2

(R,S,R)-AHPC-NHBoc

(R,S,R)-AHPC-NHBoc is a ligand for the E3 ubiquitin ligase VHL that facilitates the recruitment of the VHL protein. This compound can be utilized to construct PROTACs by linking it to a target protein ligand through a suitable linker. Its ability to modulate protein degradation pathways makes it a valuable tool for research in targeted protein degradation and related therapeutic applications.

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Cat. No.

A80977

CAS No.

2925094-80-8

CRBN ligand-763

CRBN ligand-763 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker to generate a PROTAC (proteolysis-targeting chimera), enabling targeted protein degradation. It serves as a valuable tool in drug discovery and therapeutic research aimed at modulating protein levels within cells.

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Cat. No.

A80978

CAS No.

3030284-74-0

CRBN ligand-236

CRBN ligand-236 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of CRBN to target proteins, enabling the development of proteolysis-targeting chimeras (PROTACs). CRBN ligand-236 serves as a valuable tool for studying protein degradation pathways and exploring new therapeutic strategies in cellular biology and drug discovery.

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Cat. No.

A80979

CAS No.

2925095-67-4

CRBN ligand-628

CRBN ligand-628 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to effectively recruit the CRBN protein. It can be utilized to conjugate with a target protein ligand through a linker, facilitating the formation of PROTACs (proteolysis-targeting chimeras). This compound serves as a valuable tool in targeted protein degradation research, enabling the investigation of protein function and regulation in various biological contexts.

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Cat. No.

A80980

CAS No.

2925076-26-0

CRBN ligand-521

CRBN ligand-521 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this essential protein. It can be conjugated to a target protein ligand through a linker to create a PROTAC, enabling targeted protein degradation. This reagent is valuable for research applications in drug discovery and development, particularly in the study of protein homeostasis and therapeutic intervention.

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Cat. No.

A80981

CAS No.

2925089-73-0

CRBN ligand-358

CRBN ligand-358 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized in the development of PROTACs by linking it to a target protein ligand through a suitable linker, enabling targeted protein degradation. Its applications in chemical biology research include studying protein homeostasis and dissecting cellular pathways.

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Cat. No.

A80982

CAS No.

2925072-32-6

CRBN ligand-671

CRBN ligand-671 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of CRBN to target proteins, enabling the development of targeted protein degradation strategies through the formation of PROTACs (Proteolysis Targeting Chimeras). CRBN ligand-671 is instrumental in research applications focusing on protein regulation and cellular signaling pathways.

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Cat. No.

A80983

CAS No.

2925079-57-6

CRBN ligand-439

CRBN ligand-439 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN for targeted protein degradation. This compound can be conjugated to a target protein ligand through a linker to form a PROTAC, enabling the modulation of protein levels and function in various biological contexts. It serves as a valuable tool for researchers investigating targeted protein degradation pathways and the role of CRBN in cellular processes.

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Cat. No.

A80984

CAS No.

2925080-89-1

CRBN ligand-657

CRBN ligand-657 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized in the development of PROTACs by linking it to a target protein ligand through a suitable linker. CRBN ligand-657 is valuable for investigating the mechanisms of targeted protein degradation and exploring therapeutic possibilities in various diseases.

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Cat. No.

A80985

CAS No.

2925097-26-1

CRBN ligand-343

CRBN ligand-343 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), functioning primarily to recruit the CRBN protein. This compound can be conjugated to target protein ligands through a linker, facilitating the formation of PROTACs (proteolysis-targeting chimeras). It is valuable in research applications focused on targeted protein degradation and modulation of cellular protein levels, contributing to novel therapeutic strategies.

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Cat. No.

A80986

CAS No.

2925097-74-9

CRBN ligand-536

CRBN ligand-536 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized in the design of PROTACs by linking it to a specific target protein ligand through a suitable linker, enabling targeted protein degradation. CRBN ligand-536 is instrumental for research applications in the fields of targeted therapy and proteomics.

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Cat. No.

A80987

CAS No.

2925072-72-4

CRBN ligand-701

CRBN ligand-701 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to target protein ligands through a linker to create PROTAC molecules, enabling targeted protein degradation. Its applications extend to research in targeted therapy and the study of protein regulation within cellular systems.

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Cat. No.

A80988

CAS No.

2925076-43-1

CRBN ligand-424

CRBN ligand-424 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is designed for use in PROTAC (Proteolysis Targeting Chimeras) development by linking to target protein ligands through a suitable linker. Its capacity to modulate protein degradation pathways makes it valuable for research in targeted protein degradation and therapeutic development.

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Cat. No.

A80989

CAS No.

3031608-64-4

CRBN ligand-683

CRBN ligand-683 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is particularly valuable for the development of PROTAC (Proteolysis Targeting Chimeras) by linking to target protein ligands through a suitable linker. CRBN ligand-683 is instrumental in studies of targeted protein degradation and may be harnessed in various research applications related to proteostasis and disease modulation.

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Cat. No.

A80990

CAS No.

2925085-57-8

CRBN ligand-510

CRBN ligand-510 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC. It plays a significant role in targeted protein degradation research, providing valuable insights for drug development and therapeutic interventions.

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