E3 Ligase Ligands

Cat. No.

A80991

CAS No.

2925081-67-8

CRBN ligand-696

CRBN ligand-696 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It is designed to facilitate the recruitment of cereblon to specific target proteins. By linking CRBN ligand-696 to a target protein ligand through a suitable linker, it enables the formation of proteolysis-targeting chimeras (PROTACs), which are valuable tools for targeted protein degradation studies and therapeutic applications in cancer and other diseases.

Cat. No.

A80992

CAS No.

2925095-92-5

CRBN ligand-308

CRBN ligand-308 is an E3 ubiquitin ligase cereblon (CRBN) ligand that facilitates the recruitment of the cereblon protein. This compound can be utilized to chemically link to a target protein ligand through a suitable linker, enabling the development of proteolysis-targeting chimeras (PROTACs). Its ability to modulate protein degradation pathways makes it a valuable tool for studying protein turnover and the therapeutic potential of targeted protein degradation in various biological contexts.

Cat. No.

A80993

CAS No.

2378582-97-7

Thalidomide-SH

Thalidomide-SH is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of cereblon to target proteins, enabling targeted protein degradation through PROTAC technology. Thalidomide-SH serves as a versatile tool in chemical biology and drug discovery, offering potential applications in studying protein regulation and developing new therapeutic strategies.

Cat. No.

A80994

CAS No.

2736511-31-0

CRBN ligand-412

CRBN ligand-412 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of CRBN to target proteins, enabling the formation of proteolysis-targeting chimeras (PROTACs). This compound is essential for studies focused on targeted protein degradation and therapeutic applications in cancer research and other diseases.

Cat. No.

A80995

CAS No.

2925087-52-9

CRBN ligand-578

CRBN ligand-578 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. It can be conjugated to target protein ligands through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimera). This compound is valuable for studies in targeted protein degradation and cellular protein modulation, making it useful in therapeutic research and drug development.

Cat. No.

A80996

CAS No.

2925082-20-6

CRBN ligand-455

CRBN ligand-455 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the cereblon protein. This compound can be utilized to create proteolysis-targeting chimeras (PROTACs) by linking to a target protein ligand through a suitable linker, enabling targeted protein degradation. It serves as a valuable tool for exploring protein function and regulation, particularly in the context of drug discovery and therapeutic development.

Cat. No.

A80997

CAS No.

2789680-40-4

CRBN ligand-392

CRBN ligand-392 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of CRBN to specific target proteins. This compound is utilized in the development of proteolysis-targeting chimeras (PROTACs) when covalently linked to a target protein ligand through a suitable linker, enabling selective degradation of the target protein. Research applications include targeted protein degradation studies and exploring novel therapeutic approaches in cellular biology.

Cat. No.

A80998

CAS No.

2925069-56-1

CRBN ligand-391

CRBN ligand-391 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of proteolysis-targeting chimeras (PROTACs). It plays a significant role in targeted protein degradation research and drug discovery applications, contributing to advancements in therapeutic strategies for various diseases.

Cat. No.

A80999

CAS No.

2925098-95-7

CRBN ligand-626

CRBN ligand-626 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This molecule can be conjugated to a target protein ligand through a linker, enabling the formation of a proteolysis-targeting chimera (PROTAC). Researchers can utilize CRBN ligand-626 in studies exploring targeted protein degradation and the modulation of various biological pathways.

Cat. No.

A81001

CAS No.

2925100-09-8

CRBN ligand-757

CRBN ligand-757 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a proteolysis-targeting chimeric molecule (PROTAC). CRBN ligand-757 serves as a valuable tool in chemical biology and therapeutic development, particularly in studies focused on targeted protein degradation.

Cat. No.

A81002

CAS No.

2925097-88-5

CRBN ligand-535

CRBN ligand-535 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is suitable for use in the development of PROTACs, enabling targeted protein degradation through an innovative bifunctional mechanism. Its ability to bridge ligands to target proteins makes it valuable for researchers studying ubiquitin-proteasome system modulation and therapeutic protein degradation strategies.

Cat. No.

A81003

CAS No.

2438243-28-6

Desamino lenalidomide-4-F-7-Br

Desamino lenalidomide-4-F-7-Br is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of CRBN, enabling targeted protein degradation through the formation of PROTACs when linked with a target protein ligand. Its application in research includes investigating the role of CRBN in various cellular processes and potential therapeutic strategies in cancer and other diseases.

Cat. No.

A81004

CAS No.

2925069-79-8

CRBN ligand-443

CRBN ligand-443 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be utilized in the development of PROTAC (Proteolysis Targeting Chimeras) by linking it to a target protein ligand through a suitable linker. Its application in targeted protein degradation supports innovative research in therapeutic development and cellular regulation.

Cat. No.

A81005

CAS No.

2357110-15-5

Thalidomide-Piperazine-PEG2-NH2 hydrochloride

Thalidomide-Piperazine-PEG2-NH2 hydrochloride is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be utilized in the development of PROTACs by linking it to a target protein ligand via a suitable linker, thus advancing research in targeted protein degradation and related therapeutic applications. Its ability to modulate protein levels makes it a valuable tool in cellular and molecular biology studies.

Cat. No.

A81006

CAS No.

2925097-66-9

CRBN ligand-484

CRBN ligand-484 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to target protein ligands through a linker, enabling the development of PROTACs that promote targeted protein degradation. Its utility in research includes exploring the mechanisms of ubiquitin-proteasome system modulation and protein homeostasis in cellular contexts.

Cat. No.

A81007

CAS No.

1797406-78-0

(S,S,S)-AHPC

Synonyms: (S,S,S)-VH032-NH2

(S,S,S)-AHPC is a specific ligand for E3 ligases, serving as a crucial component in targeted protein degradation applications. It is utilized for the synthesis of PROTAC AH081, which can facilitate the degradation of specific proteins within cells. This compound is an important tool in research focused on understanding protein interactions and developing novel therapeutic strategies through modulation of E3 ligase activity.

Cat. No.

A81008

CAS No.

2925096-35-9

CRBN ligand-488

CRBN ligand-488 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN for targeted protein degradation. This compound can be conjugated with a target protein ligand through a linker to create a proteolysis-targeting chimera (PROTAC). Its utility in targeted protein elimination makes it an important tool for investigating cellular processes and therapeutic applications in cancer and other diseases.

Cat. No.

A81009

CAS No.

2925087-92-7

CRBN ligand-741

CRBN ligand-741 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of cereblon, enabling the formation of proteolysis-targeting chimeras (PROTACs) when linked to a target protein ligand via a suitable linker. This compound is valuable for studies in targeted protein degradation, offering potential applications in drug development and cancer research.

Cat. No.

A81010

CAS No.

2925095-97-0

CRBN ligand-307

CRBN ligand-307 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of PROTACs (proteolysis-targeting chimeras). CRBN ligand-307 is valuable in research applications focused on targeted protein degradation and the modulation of cellular protein levels, making it an essential tool for studies in drug discovery and therapeutic development.

Cat. No.

A81011

CAS No.

3065496-78-5

CRBN ligand-45

CRBN ligand-45 functions as a ligand for the CRBN-type E3 ubiquitin ligase, facilitating targeted protein degradation through the proteolysis-targeting chimera (PROTAC) technology. This compound is essential for research applications focused on investigating ubiquitination pathways and developing novel therapeutic strategies that harness the ubiquitin-proteasome system. Its ability to selectively engage E3 ligases makes it a valuable tool in the study of cellular protein homeostasis and degradation mechanisms.

Cat. No.

A81012

CAS No.

2825006-38-8

Thalidomide-5-methanol

Thalidomide-5-methanol is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound has applications in the development of proteolysis-targeting chimeras (PROTACs) by enabling the linkage to target protein ligands via a suitable linker. Thalidomide-5-methanol is utilized in research exploring targeted protein degradation and the therapeutic potential of modulating CRBN activity.

Cat. No.

A81013

CAS No.

2573307-29-4

CRBN ligand-796

CRBN ligand-796 serves as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound is designed for use in PROTAC (PROteolysis TArgeting Chimeras) technology, allowing for the targeted degradation of proteins by linking to specific target protein ligands through a suitable linker. Its role in modulating protein degradation pathways makes it a valuable tool for research in targeted therapeutics and cellular signaling studies.

Cat. No.

A81014

CAS No.

2925081-29-2

CRBN ligand-589

CRBN ligand-589 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated with a target protein ligand through a linker to create a proteolysis-targeting chimeric molecule (PROTAC). Its applications in chemical biology include the modulation of protein degradation pathways and the investigation of targeted protein therapy mechanisms.

Cat. No.

A81015

CAS No.

2933136-83-3

CRBN ligand-229

CRBN ligand-229 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be successfully linked to a target protein ligand through a linker to create a PROTAC (proteolysis-targeting chimera). Research applications of CRBN ligand-229 include targeted protein degradation and the study of ubiquitin-mediated proteostasis pathways.

Cat. No.

A81016

CAS No.

2357111-30-7

CRBN ligand-858

CRBN ligand-858 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is instrumental in the development of proteolysis-targeting chimeras (PROTACs) when linked to a target protein ligand through an appropriate linker. Its applications extend to advancing research in targeted protein degradation and exploring novel therapeutic strategies.