Vasopressin Receptor

Cat. No.

A64033

CAS No.

877856-17-2

VA-111913

Synonyms: VT-913

VA-111913 is a potent antagonist of the vasopressin receptor V1A, exhibiting a Ki value of 1.74 nM. This compound has demonstrated efficacy in reducing uterine contractions and enhancing uterine blood flow through the inhibition of vasopressin, making it relevant for studies focused on alleviating dysmenorrhea. VA-111913 serves as a valuable tool for research on menstrual pain and its associated mechanisms.

Cat. No.

A64034

CAS No.

1245620-47-6

Ribuvaptan

Ribuvaptan is a vasopressin receptor antagonist that plays a crucial role in cardiovascular research. This compound is primarily utilized for studying heart failure and related conditions. Through its mechanism of inhibiting vasopressin receptors, Ribuvaptan shows promise in elucidating the pathophysiology of heart failure and evaluating potential therapeutic strategies.

Cat. No.

A64036

CAS No.

1056550-56-1

V1b Receptor antagonist-1

V1b Receptor Antagonist-1 is a selective antagonist targeting the vasopressin 1b (V1b) receptor. This compound demonstrates significant antidepressant activity and is applicable in research focused on neurological disorders, particularly depression. Its ability to penetrate the blood-brain barrier enhances its suitability for studies investigating the role of V1b receptor modulation in therapeutic interventions for mood disorders.

Cat. No.

A64037

CAS No.

2296801-25-5

Elsovaptan

Elsovaptan is a selective vasopressin receptor antagonist that disrupts the action of vasopressin at its receptors, demonstrating potential in modulating fluid balance and blood pressure. This compound is primarily utilized in research related to neurodegenerative disorders, particularly Alzheimer’s disease. Through its mechanism, Elsovaptan may aid in elucidating the role of vasopressin signaling in cognitive decline and related pathologies.

Cat. No.

A64039

CAS No.

1622294-25-0

ML389

ML389 is a highly selective V1a receptor antagonist, displaying an IC50 value of 40 nM. This compound demonstrates significant potential in the research of central nervous system disorders, including anxiety, depression, and post-traumatic stress disorder (PTSD). Its ability to effectively inhibit the V1a receptor may contribute to advanced studies in neuropharmacology and therapeutic targeting.

Cat. No.

A64041

CAS No.

64158-84-5

[Deamino-Pen1,Val4,D-Arg8]-vasopressin

[Deamino-Pen1,Val4,D-Arg8]-vasopressin is a selective arginine-vasopressin (AVP) antagonist. This compound has been shown to significantly reduce plasma aldosterone concentrations in rat models. It serves as a valuable tool for investigating the growth and steroidogenic activity of the adrenal zona glomerulosa in rats.

Cat. No.

A64042

CAS No.

1021701-88-1

Val9-Oxytocin

Val9-Oxytocin is a selective antagonist of the vasopressin V1a receptor. This compound is a synthetic analog of oxytocin, with a substitution of valine for glycine at position 9. Val9-Oxytocin exhibits key biological activity in modulating V1a receptor signaling pathways, making it valuable for research applications related to cardiovascular, neuroendocrine, and behavioral studies.

Cat. No.

A64046

CAS No.

210101-16-9

Conivaptan

Synonyms: YM 087 free base

Conivaptan is a dual antagonist of the vasopressin V1A and V2 receptors. It has been shown to improve outcomes in congestive heart failure by ameliorating fluid retention and enhancing cardiac systolic function. This compound is valuable in research applications related to cardiovascular physiology and the modulation of water homeostasis.

Cat. No.

A64047

CAS No.

176714-12-8

(d(CH2)51,Tyr(Me)2,Dab5,Arg8)-Vasopressin

Synonyms: d(CH2)5[Tyr(Me)2, Dab5]AVP

(d(CH2)51,Tyr(Me)2,Dab5,Arg8)-Vasopressin is a selective antagonist of the vasopressin V1a receptor, exhibiting a pA2 value of 6.71. This compound is instrumental in studying vasopressin's role in various physiological processes and pathophysiological conditions. Its specificity makes it a valuable tool for research related to vascular regulation, fluid balance, and associated disorders.

Cat. No.

A64050

CAS No.

331947-66-1

(R)-(+)-Tolvaptan

Synonyms: (R)-(+)-OPC-41061

(R)-(+)-Tolvaptan is the (R)-(+) enantiomer of the vasopressin receptor 2 (V2R) antagonist Tolvaptan. This compound exhibits selective and competitive inhibition of V2R, making it valuable for exploring the role of vasopressin in kidney function and fluid balance. It is widely used in research related to renal pathophysiology, particularly in the study of conditions such as heart failure and polycystic kidney disease.