MDM2

Cat. No.

A11501

CAS No.

675576-98-4

Nutlin 3a

Synonyms: (-)-Nutlin-3

Nutlin 3a is a potent inhibitor of MDM2 (mouse double minute 2) binding to p53 that induces the expression of p53 regulated genes, and shows potent antiproliferative activity in cells expressing functional p53.

Cat. No.

A15352

CAS No.

431979-47-4

SJ 172550

SJ 172550 is the first MDMX inhibitor with EC50 of 0.84 uM; binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified.

Cat. No.

A20954

CAS No.

13614-98-7

Minocycline hydrochloride

Minocycline hydrochloride is a broad-spectrum tetracycline antibiotic, acting by binding to the bacterial 30S ribosomal subunit and inhibiting protein synthesis.

Cat. No.

A11179

CAS No.

58131-57-0

NSC-207895 (XI-006)

Synonyms: XI-006

NSC207895 is a cell-permeable benzofuroxan compound that downregulates the p53 negative regulator MDMX protein level in MCF-7, LNCaP, and A549 cells (1 to 10 µM for 16 to 24 h) by suppressesing MDMX promoter transcription activity (IC50 = 2.5 µM in HT1080 cells), leading to enhanced p53 stabilization and activation.

Cat. No.

A11502

CAS No.

675576-97-3

Nutlin 3b

Synonyms: (+)-Nutlin-3

Nutlin 3b is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 uM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a.

Cat. No.

A11523

CAS No.

939981-39-2

RG7112

Synonyms: RO5045337

RG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2.

Cat. No.

A12575

CAS No.

1818393-16-6

APG-115

APG-115 (AA-115) is an orally active MDM2 protein inhibitor binding to MDM2 protein with IC50 and Ki values of 3.8 nM and 1 nM, respectively.

Cat. No.

A13480

CAS No.

1049704-18-8

MA242

MA242 is a dual inhibitor of murine double minute 2 (MDM2) and nuclear factor of activated T cells 1 (NFAT1) for Pancreatic Cancer Therapy.

Cat. No.

A13582

CAS No.

562823-84-1

MDM2 Inhibitor

MDM2 Inhibitor is a cell-permeable boranyl-chalcone exhibiting strong binding to MDM2 and irreversibly disrupts the MDM2/p53 protein complex.

Cat. No.

A14211

CAS No.

1229705-06-9

Idasanutlin (RG7388)

Synonyms: RG-7388

Idasanutlin is a potent and selective p53-MDM2 inhibitor.

Cat. No.

A14394

CAS No.

1352066-68-2

AMG232

AMG 232 is a highly potent, selective and orally bioavailable piperidinone inhibitor of the MDM2-p53 interaction((SPR KD= 0.045 nM, SJSA-1 EdU IC50=9.1 nM).

Cat. No.

A14423

CAS No.

1303607-07-9

MI-773 (SAR405838)

Synonyms: MI 773

MI-773 is a new small molecule inhibitor of the MDM2-p53 interaction, binds to MDM2 with high affinity (Ki=0.88 nM) and blocks the p53-MDM2 interaction.

Cat. No.

A15201

CAS No.

939981-37-0

p53 and MDM2 proteins-interaction-inhibitor chiral

p53 and MDM2 proteins-interaction-inhibitor chiral is an inhibitor of the interaction between p53 and MDM2 proteins.

Cat. No.

A15202

CAS No.

939983-14-9

p53 and MDM2 proteins-interaction-inhibitor racemic

Synonyms: p53 inhibitor (racemic)

p53 and MDM2 proteins-interaction-inhibitor racemic is an inhibitor of the interaction between p53 and MDM2 proteins.

Cat. No.

A16326

CAS No.

1313363-54-0

NVP-CGM097

Synonyms: CGM097

NVP-CGM097 is a potent and selective MDM2 inhibitor; an orally bioavailable HDM2 antagonist with potential antineoplastic activity.

Cat. No.

A16348

CAS No.

1005264-47-0

MX-69

MX-69 is the MDM2/XIAP inhibitor, used for cancer treatment.

Cat. No.

A16834

CAS No.

1448867-41-1

HDM201

Synonyms: NVP-HDM201

HDM201 is a novel, highly potent and selective inhibitor of the p53-Mdm2 interaction with affinity constant for Mdm2 in the picomolar range and a selectivity ratio greater than 10000-fold vs Mdm4.

Cat. No.

A18450

CAS No.

1410737-34-6

MI-1061

MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM). MI-1061 potently activates p53, induces apoptosis, and has anti-tumor activity.

Cat. No.

A18813

CAS No.

1416663-77-8

RO-5963

RO-5963 is an inhibitor of the interaction of both MDM2 and MDMX with p53 with IC50s of ~17 nM and ~24 nM, respectively.

Cat. No.

A20456

CAS No.

1398568-47-2

Milademetan

Synonyms: DS-3032

Mliademetan is a specific MDM2 inhibitor, a pharmaceutical composition for use in treating acute myeloid leukemia (AML).

Cat. No.

A20724

CAS No.

85532-75-8

PK 11195

Synonyms: RP 52028

PK 11195 is a 2 Phenylindolylglyoxylyldipeptide Murine Double Minute (MDM)2/Translocator Protein (TSPO) Dual Inhibitor, and is potentially useful for the Treatment of Gliomas.

Cat. No.

A20824

CAS No.

1818291-27-8

BI-0252

BI-0252 is an orally active, selective MDM2-p53 inhibitor with an IC50 of 4 nM.

Cat. No.

A20865

CAS No.

1309684-94-3

RO8994

RO8994 is a highly potent and selective series of spiroindolinone small-molecule MDM2 inhibitor, with IC50 of 5 nM (HTRF binding assays) and 20 nM (MTT proliferation assays).

Cat. No.

A25313

CAS No.

2180931-49-9

LQFM030

LQFM030 is a novel small molecule inhibitor of MDM2, primarily targeting the MDM2-p53 interaction to promote cellular apoptosis. It demonstrates concentration-dependent cytotoxicity in K562 cells with an IC50 value of 0.28 mM, inducing G0/G1 phase cell cycle arrest and enhancing Caspase activity. LQFM030 also downregulates the expression of key oncogenes and proteins, including MDM2, MDMX, p73, MYC, and NF-κB. This compound is particularly valuable in cancer research, especially in the study of leukemia.

Cat. No.

A25435

CAS No.

2093449-12-6

ASTX295

ASTX295 is a selective MDM2 inhibitor that effectively disrupts the MDM2-p53 interaction, exhibiting an IC50 of less than 1 nM. By activating wild-type TP53, ASTX295 induces the expression of key transcriptional targets, resulting in cell death. This compound promotes the transition of pancreatic cancer cells from senescence to apoptosis while modulating p53 and DNA damage biomarkers. ASTX295 is suitable for research applications in hematologic malignancies and pancreatic cancer.