PLK

Cat. No.

A10134

CAS No.

755038-02-9

BI 2536

BI 2536 is a selective inhibitor of Plk1, which inhibits Plk1 enzyme activity at low nanomolar concentrations.

Cat. No.

A10135

CAS No.

755038-65-4

Volasertib (BI6727)

Synonyms: BI6727

BI6727 is a highly potent and selective polo-like kinase (PLK) 1 inhibitor (enzyme IC50 = 0.87 nM, EC50 = 11-37 nM on a panel of cancer cell lines).

Cat. No.

A10452

CAS No.

173529-46-9

HMN-214

Synonyms: IVX-214

HMN-214 inhibits polo-like and cyclin-dependent kinase activity, has potent antimicrotubular effects and results in profound apoptosis and antitumor activity in a broad spectrum of human xenografts.

Cat. No.

A11438

CAS No.

660868-91-7

GW843682X

GW843682X is a selective inhibitor of polo-like kinase 1 (PLK1) and polo-like kinase 3 (PLK3) (IC50 values are 2.2 and 9.1 nM respectively).

Cat. No.

A12429

CAS No.

1228960-69-7

MLN 0905

MLN0905 is a potent, selective small-molecule PLK1 inhibitor. MLN0905 inhibits cell proliferation in a broad range of human tumor cells including DLBCL cell lines.

Cat. No.

A10442

CAS No.

929095-18-1

GSK461364

GSK461364 is an ATP-competitive inhibitor of polo-like kinase 1 (Plk1).

Cat. No.

A10673

CAS No.

1225497-78-8

(E/Z)-Rigosertib sodium ((E/Z)-ON-01910)

Synonyms: Estybon; Novonex; (E/Z)-ON-01910 sodium; (E/Z)-ON-01910

ON-01910 is selectively cytotoxic for chronic lymphocytic leukemia cells through a dual mechanism of action involving PI3K/AKT inhibition and induction of oxidative stress.

Cat. No.

A11146

CAS No.

1137868-52-0

TAK-960

TAK-960 is a novel, orally available, selective inhibitor of polo-like kinase 1, shows broad-spectrum preclinical antitumor activity.

Cat. No.

A11524

CAS No.

321688-88-4

Poloxin

Poloxin is a non-ATP competitive Polo-like Kinase 1 (PLK1) inhibitor that targets the polo-box domain, with an IC50 of appr 4.8 μM.

Cat. No.

A12145

CAS No.

17302-61-3

Poloxime

Poloxime, a hydrolysis product of poloxin, is a non-ATP-competitive Plk1 inhibitor, with moderate Plk1 inhibitory activity.

Cat. No.

A13045

CAS No.

1034616-18-6

NMS-1286937

Synonyms: NMS-P937

NMS-1286937 is an orally bioavailable, small-molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity.

Cat. No.

A13245

CAS No.

1062243-51-9

RO3280

RO3280 is a potent, highly selective inhibitor of Polo-like kinase 1 (PLK1) with IC50 of 3 nM.

Cat. No.

A14426

CAS No.

1052532-15-6

SBE 13 HCl

Synonyms: SBE-13

SBE 13 HCl is a selective inhibitor of PLK1 (IC50 values are 200 pM, 875 nM and 66 μM for PLK1, PLK3 and PLK2 respectively).

Cat. No.

A16261

CAS No.

244240-24-2

(Z)-LFM-A13

Synonyms: LFM A13

LFM-A13 is a potent and selective inhibitor of Btk with IC50 of 17.2 uM; also inhibits PLK3 with IC50 of 7.2 uM.

Cat. No.

A19085

CAS No.

2247919-28-2

AAPK-25

AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in a prometaphase, reflecting by the biomarker histone H3Ser10 phosphorylation and followed by a surge in apoptosis.

Cat. No.

A19952

CAS No.

1082739-92-1

TC-S 7005

TC-S 7005 is a Polo-like kinases (Plks) inhibitor with IC50s of 4 nM, 24 nM and 214 nM for Plk2, Plk3, and Plk1, respectively.

Cat. No.

A20855

CAS No.

1798871-31-4

Centrinone-B

Synonyms: LCR-323

Centrinone-B (LCR-323) is a potent and highly selective PLK4 inhibitor, with a Ki of 0.59 nM.

Cat. No.

A20858

CAS No.

1798871-30-3

Centrinone

Synonyms: LCR-263

Centrinone (LCR-263) is a selective and reversible inhibitor of polo-like kinase 4 (PLK4) with a Ki of 0.16 nM.

Cat. No.

A21696

CAS No.

775294-82-1

SBE13

SBE13 is a potent and selective Plk1 inhibitor, with an IC50 of 200 pM; SBE13 poorly inhibits Plk2 (IC50>66 μM) or Plk3 (IC50=875 nM).

Cat. No.

A21703

CAS No.

1137868-96-2

TAK-960 hydrochloride

Synonyms: TAK 960

TAK-960 hydrochloride is an orally available, selective inhibitor of polo-like kinase 1 (PLK1), with an IC50 of 0.8 nM at 10 μM ATP; TAK-960 hydrochloride also shows inhibitory activities against PLK2 and PLK3, with IC50s of 16.9 and 50.2 nM, respectively.

Cat. No.

A21868

CAS No.

592542-59-1

Rigosertib

Synonyms: ON-01910

Rigosertib (ON-01910) is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition the PI3 kinase/Akt pathway, promots the phosphorylation of histone H2AX and induces G2/M arrest in cell cycle.

Cat. No.

A22039

CAS No.

1228817-38-6

Mps1-IN-2

Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor, with an IC50 and a Kd of 145 nM and 12 nM for Mps1 and a Kd of 61 nM for Plk1.

Cat. No.

A22256

CAS No.

1338806-73-7

CFI-400945

CFI-400945 is an orally active, potent and selective polo-like kinase 4(PLK4) inhibitor with Ki value of 0.26 nM.

Cat. No.

A22463

CAS No.

1247000-76-5

CFI-400437 HCl

Synonyms: CFI-400437 hydrochloride; CFI-400437 dihydrochloride; CFI-400437

CFI-400437 is a potent and selective inhibitor of polo-like kinase 4 (PLK4).

Cat. No.

A30093

CAS No.

1312471-39-8

ON1231320

ON1231320 is a selective inhibitor of polo-like kinase 2 (PLK2), exhibiting an IC50 of 0.31 μM. This compound disrupts tumor cell cycle progression specifically at the G2/M phase during mitosis, leading to apoptotic cell death. The arylsulfonyl pyrido-pyrimidinone structure contributes to its significant antitumor activity, making ON1231320 a valuable tool for research in cancer biology and therapeutic development.