ROCK

Cat. No.

A11001

CAS No.

129830-38-2

Y-27632 2HCl

Y-27632 is a Rho-Associated Coil Kinase (ROCK) inhibitor that increases the cloning efficiency of human embryonic stem cells (hESCs).

Cat. No.

A21448

CAS No.

146986-50-7

Y-27632

Y-27632 is an ATP-competitive inhibitor of ROCK-I and ROCK-II, with Ki of 220 nM and 300 nM for ROCK-I and ROCK-II, respectively.

Cat. No.

A31505

CAS No.

331752-47-7

Y-27632 hydrochloride hydrate

Y-27632 hydrochloride hydrate is a selective inhibitor of Rho-associated protein kinases (ROCK-I and ROCK-II), exhibiting ATP-competitive activity with IC50 values of 220 nM and 300 nM, respectively. This compound has been shown to reduce Doxorubicin-induced apoptosis in human cardiac stem cells and suppress apoptosis in dissociation-induced murine prostate stem/progenitor cells. Additionally, Y-27632 hydrochloride hydrate enhances the differentiation of human induced pluripotent stem cells (hIPSCs) towards a mesendodermal lineage by modulating epithelial-mesenchymal transition.

Cat. No.

A10381

CAS No.

105628-07-7

Fasudil HCl (HA-1077 Hydrochloride)

Synonyms: AT-877; HA-1077; HA-1077 Hydrochloride

Fasudil HCl is a cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50 = 10.7 μM).

Cat. No.

A15225

CAS No.

867017-68-3

Azaindole 1 (BAY-549)

Synonyms: ROCK-IN-2; TC-S 7001; BAY-549

Azaindole 1 (BAY-549) is a highly potent inhibitor of human ROCK-1 and ROCK-2 isoenzymes with IC50 values of 0.6 and 1.1 nM, respectively.

Cat. No.

A15888

CAS No.

887375-67-9

Ripasudil

Synonyms: K 115

Ripasudil (K-115) is potent ROCK inhibitor with IC50 of 51 nM and 19 nM for ROCK1 and ROCK2, respectively, used for the treatment of glaucoma and ocular hypertension.

Cat. No.

A12348

CAS No.

850664-21-0

GSK 269962

Synonyms: GSK269962A

GSK 269962 is a potent Rho kinase (ROCK) inhibitor (IC50 values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively).

Cat. No.

A10441

CAS No.

864082-47-3

GSK429286A

GSK429286A is a cell-permeable, selective small molecule inhibitor of Rho-associated, coiled-coil containing protein kinase (ROCK).

Cat. No.

A10899

CAS No.

1342276-76-9

RKI-1313

RKI-1313 is a negative control for RKI-1447 which is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer.

Cat. No.

A10928

CAS No.

1226056-71-8

Thiazovivin

Thiazovivin is a selective inhibitor of Rho-associated kinase (ROCK).

Cat. No.

A11610

CAS No.

199433-58-4

Y-33075

Y-33075 is ROCK (Rho-associated coiled coil-forming protein kinase) inhibitor.

Cat. No.

A11611

CAS No.

173897-44-4

Y-33075 dihydrochloride

Y-33075 dihydrochloride is a selective ROCK inhibitor with an IC50 of 3.6 nM.

Cat. No.

A12464

CAS No.

1056901-62-2

AT13148

AT13148 is a novel oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors.

Cat. No.

A12674

CAS No.

1072959-67-1

SR 3677

SR 3677  is a potent and selective Rho-kinase inhibitor (IC50 values are 3 and 56 nM for ROCK-II and ROCK-I respectively).

Cat. No.

A13067

CAS No.

1342278-01-6

RKI-1447

Synonyms: RKI 1447. ROCK Inhibitor XIII

RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer.

Cat. No.

A13659

CAS No.

913844-45-8

Glycyl-H 1152 2HCl

Synonyms: Rho Kinase Inhibitor IV

Glycyl-H 1152 2HCl is a selective and potent ROCK inhibitor (IC50 values are 0.0118, 2.35, 2.57, 3.26, > 10 and >10 uM for ROCKII, Aurora A, CAMKII, PKG, PKA and PKC respectively.)

Cat. No.

A13785

CAS No.

203911-27-7

HA-1077 dihydrochloride

Synonyms: Fasudil dihydrochloride; HA1077

HA-1077 inhibits vascular smooth muscle contraction by acting as an intracellular Ca2+ antagonist.

Cat. No.

A15045

CAS No.

1273579-40-0

chroman 1

Synonyms: ROCK-II inhibitor

Chroman 1 is a highly potent and selective ROCK II inhibitor.

Cat. No.

A15101

CAS No.

451462-58-1

H-1152

H-1152, an isoquinolinesulfonamide derivative, is a more specific, stronger and membrane-permeable inhibitor of Rho-kinase with a Ki value of 1.6 nM, but poor inhibitor of other serine/threonine kinases.

Cat. No.

A15102

CAS No.

871543-07-6

H-1152 dihydrochloride

H-1152 dihydrochloride, an isoquinolinesulfonamide derivative, is a more specific, stronger and membrane-permeable inhibitor of Rho-kinase with a Ki value of 1.6 nM, but poor inhibitor of other serine/threonine kinases.

Cat. No.

A15118

CAS No.

105628-72-6

Hydroxyfasudil

Synonyms: HA-1100

Hydroxyfasudil, metabolite of Fasudil, is a potent Rho-kinase inhibitor and vasodilator.

Cat. No.

A15119

CAS No.

155558-32-0

Hydroxyfasudil hydrochloride

Synonyms: HA-1100 hydrochloride

Hydroxyfasudil hydrochloride, metabolite of Fasudil, is a potent Rho-kinase inhibitor and vasodilator.

Cat. No.

A15226

CAS No.

1415565-02-4

ROCK inhibitor-1

N/A

Cat. No.

A15239

CAS No.

911417-87-3

SLx-2119 (KD025)

Synonyms: SLx 2119; ROCK inhibitor; KD-025

SLx-2119 is a small molecule and selective inhibitor of ROCK2 with IC50 of 105 nM; > 200 fold selecivity over ROCK1(IC50 =24 uM).

Cat. No.

A15921

CAS No.

923262-96-8

SAR407899 HCl

Synonyms: SAR 407899

SAR407899 is a potent and selective Rho kinase inhibitor with promising antihypertensive activity.