Hydroxylases

Cat. No.

A11172

CAS No.

170151-24-3

Nepicastat HCl

Synonyms: RS-25560-197; SYN117

Nepicastat hydrochloride is an inhibitor of dopamine beta-hydroxylase, an enzyme that catalyzes the conversion of dopamine to norepinephrine.

Cat. No.

A13363

CAS No.

54-36-4

Metyrapone

Metyrapone is an inhibitor of cytochrome P450-mediated ω/ω-1 hydroxylase activity and CYP11B1.

Cat. No.

A12833

CAS No.

199666-03-0

Ro 61-8048

Ro 61-8048 is a potent and competitive kynurenine 3-hydroxylase inhibitor (Ki = 4.8 nM, IC50 = 37 nM).

Cat. No.

A13998

CAS No.

89464-63-1

DMOG

Synonyms: Dimethyloxaloyl glycine

DMOG is a cell permeable, competitive inhibitor of HIF-PH. It acts to stabilize HIF-1α expression at normal oxygen tensions in cultured cells, at concentrations between 0.1 and 1 mM.

Cat. No.

A14325

CAS No.

945976-43-2

LP-533401

LP-533401 is a small molecule inhibitor of Tph1.

Cat. No.

A10542

CAS No.

1137608-69-5

Telotristat etiprate (LX 1606 Hippurate)

Synonyms: LX 1032; LX 1606 Hippurate

LX 1606 hippurate is an orally bioavailable, small-molecule, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.

Cat. No.

A10637

CAS No.

173997-05-2

Nepicastat (free base) (SYN-117)

Synonyms: RS-25560-197; SYN-117

Nepicastat is an inhibitor of dopamine beta-hydroxylase, an enzyme that catalyzes the conversion of dopamine to norepinephrine.

Cat. No.

A10920

CAS No.

6429-04-5

Tetrahydropapaverine HCl

Tetrahydropapaverine, one of the TIQs and an analogue of salsolinol and tetrahydropapaveroline, has been reported to have neurotoxic effects on dopamine neurons.

Cat. No.

A11371

CAS No.

223666-07-7

Collagen proline hydroxylase inhibitor

Collagen proline hydroxylase inhibitor is a collagen proline hydroxylase inhibitor.

Cat. No.

A11479

CAS No.

945976-76-1

LX-1031

LX-1031 is a potent, orally available tryptophan 5-hydroxylase (TPH) inhibitor that reduces serotonin (5-HT) synthesis peripherally.

Cat. No.

A11785

CAS No.

1033805-22-9

Telotristat ethyl (LX 1606 ethyl)

Synonyms: LX1606; LX 1606 ethyl

LX 1606 is an orally bioavailable, small-molecule, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.

Cat. No.

A14013

CAS No.

928134-65-0

Osilodrostat (LCI-699)

Synonyms: LCI-699

Osilodrostat (LCI699) is a potent inhibitor of human 11β-hydroxylase and aldosterone synthase with IC50 values of 2.5 and 0.7 nM, respectively.

Cat. No.

A14054

CAS No.

1033805-28-5

Telotristat

Synonyms: LP-778902

Telotristat (LP-778902) is a potent tryptophan hydroxylase inhibitor with an in vivo IC50 of 0.028 μM.

Cat. No.

A14602

CAS No.

32791-84-7

Panaxtriol

Panaxtriol is a tyrosine hydroxylase inducer.

Cat. No.

A15846

CAS No.

1783256-96-1

ACT-678689

ACT-678689 is a potent inhibitor of tryptophan hydroxylase (TPH), exhibiting an IC50 value of 8 nM. This compound plays a critical role in the modulation of serotonin synthesis, making it valuable for research in neuropharmacology and the study of mood disorders. Its selective inhibition of TPH allows for in-depth investigation into serotonin-related pathways and their physiological implications.

Cat. No.

A16424

CAS No.

7424-00-2

4-Chloro-DL-phenylalanine

Synonyms: Fenclonine; PCPA; CP-10188

4-Chloro-DL-phenylalanine is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE).

Cat. No.

A18820

CAS No.

1673568-73-4

Rodatristat

Synonyms: KAR5417

Rodatristat (KAR5417) is a potent tryptophan hydroxylase 1 (TPH1) and TPH2 inhibitor with IC50s value of 33 nM and 7 nM, respectively, and shows robust reduction of intestinal serotonin (5-HT) levels in mice.

Cat. No.

A19214

CAS No.

1262132-81-9

Enarodustat

Synonyms: JTZ-951

Enarodustat is a potent and orally active factor prolyl hydroxylase inhibitor, with an EC50 of 0.22 μM; Enarodustat has entered clinical trial for renal anemia.

Cat. No.

A20593

CAS No.

1673571-51-1

Rodatristat ethyl

Synonyms: KAR5585

Rodatristat ethyl (KAR5585) is a first-in-class oral tryptophan hydroxylase 1 (TPH1) Inhibitor with nanomolar in vitro potency. Rodatristat ethyl reduces the level of 5-HT and significantly reduces pulmonary arterial hypertension (PAH).

Cat. No.

A45815

CAS No.

14173-40-1

PCPA methyl ester hydrochloride

Synonyms: 4-Chloro-DL-phenylalanine methyl ester hydrochloride

PCPA methyl ester hydrochloride is a reversible inhibitor of tryptophan hydroxylase, an enzyme critical for serotonin (5-HT) synthesis. This compound effectively crosses the blood-brain barrier, leading to a reduction in central 5-HT availability. It is widely utilized in research to investigate the role of serotonin in various physiological and pathological processes.

Cat. No.

A78000

CAS No.

1040526-12-2

LP-533401 hydrochloride

LP-533401 hydrochloride is an inhibitor of tryptophan hydroxylase 1, a key enzyme in serotonin biosynthesis. By modulating serotonin production in the gut, this compound serves as a valuable tool for investigating the role of serotonin in gastrointestinal physiology and associated disorders. Its applications extend to understanding the pathophysiology of conditions related to serotonin dysregulation, including mood disorders and gastrointestinal diseases.

Cat. No.

A78002

CAS No.

7730-20-3

6-Fluorotryptophan

6-Fluorotryptophan is a competitive inhibitor of tryptophan hydroxylase, an enzyme crucial for serotonin synthesis. This compound has demonstrated significant effects on sleep disruption in animal models, particularly in rats with chronic EEG electrode implantation. Its application in research includes studies on serotonin-related disorders and the modulation of sleep patterns, providing insights into the neurochemical mechanisms underlying these processes.

Cat. No.

A78004

CAS No.

3032648-15-7

TPT-004

TPT-004 is a selective inhibitor of tryptophan hydroxylases (TPH), demonstrating IC50 values of 77 nM and 16 nM for TPH1 and TPH2, respectively. This compound exhibits strong selectivity for TPH1, targeting the production of serotonin. TPT-004 has been shown to effectively reduce peripheral serotonin levels and inhibit colorectal tumor growth in preclinical mouse models, making it a valuable tool in cancer and serotonin-related research.

Cat. No.

A78006

CAS No.

3040015-86-6

TPH1-IN-1

TPH1-IN-1 is a xanthine derivative that functions as a specific inhibitor of tryptophan hydroxylase 1 (TPH1), exhibiting an IC50 value of 110.1 nM. This compound demonstrates robust in vitro activity and is stable in liver microsomes, making it a valuable tool for studies targeting serotonin biosynthesis. TPH1-IN-1 effectively inhibits adipocyte differentiation in T3-L1 cells, highlighting its potential applications in metabolic research and related therapeutic investigations.

Cat. No.

A78007

CAS No.

1374745-52-4

Telotristat besilate

Telotristat besilate is a potent inhibitor of tryptophan hydroxylase, exhibiting an in vivo IC50 of 0.028 μM. This compound effectively modulates serotonin synthesis, making it a valuable tool for research on serotonin-related disorders and other neurochemical pathways. Its application extends to studies investigating the regulation of mood, gastrointestinal function, and tumor activity in carcinoid syndrome.