AChE

Cat. No.

A78758

CAS No.

13067-93-1

Cyanofenphos

Cyanofenphos is an orally active organophosphate compound that acts as an acetylcholinesterase (AChE) inhibitor, exhibiting neurotoxic properties. This reagent is associated with delayed neurotoxic effects, including ataxia and paralysis, and may present additional symptoms such as somnolence, decreased feed intake, and weight loss in avian models. Cyanofenphos demonstrates a self-antagonistic effect, whereby repeated low-dose pre-treatment can mitigate acute toxicity but exacerbate long-term neurotoxicity and decrease enzyme inhibition, with protective effects peaking 24 hours post-treatment. This compound is widely utilized in research focused on neurotoxicity and AChE inhibition pathways.

Cat. No.

A78759

CAS No.

2598164-15-7

TRV-7019

TRV-7019 is a brain-penetrating radioligand that targets butyrylcholinesterase, facilitating advanced imaging techniques. This compound is instrumental for diagnostic applications related to amyloid diseases, multiple sclerosis, brain tumors, and the assessment of butyrylcholinesterase activity. Its specificity and ability to cross the blood-brain barrier make it a valuable tool for neurological research and clinical diagnostics.

Cat. No.

A78760

CAS No.

118971-61-2

2-Methyl-2-butenyl (E)-Caffeate

2-Methyl-2-butenyl (E)-Caffeate is a caffeic acid ester compound that exhibits inhibitory activity against both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). It also demonstrates significant antioxidant properties, making it a valuable reagent for studying oxidative stress. This compound is particularly relevant for research related to neurodegenerative diseases such as Alzheimer's disease.

Cat. No.

A78761

CAS No.

2468035-31-4

BChE-IN-9

BChE-IN-9 (Azepano-11-deoxo-glycyrrhetol) is a mixed type inhibitor of butyrylcholinesterase (BChE) with a Ki value of 0.21 µM. This compound exhibits significant inhibitory activity, making it a valuable tool for studying cholinergic signaling pathways and neurodegenerative diseases where BChE is implicated. Its use in research can provide insights into therapeutic strategies for conditions such as Alzheimer's disease and other neurocognitive disorders.

Cat. No.

A78762

CAS No.

2413656-04-7

AChE-IN-21

AChE-IN-21 is a potent and selective inhibitor of acetylcholinesterase (AChE), exhibiting an IC50 value of 2.66 nM. This compound demonstrates significant blood-brain barrier permeability in vitro, making it suitable for central nervous system research applications. AChE-IN-21 may be utilized in studies related to neurodegenerative diseases, such as Alzheimer's disease, by modulating cholinergic signaling pathways.

Cat. No.

A78763

CAS No.

139314-01-5

Quilostigmine

Synonyms: HP-290; NXX-066

Quilostigmine is a potent acetylcholinesterase inhibitor with an IC50 of 148 nM in rat brain acetylcholinesterase. This orally active analogue of Physostigmine demonstrates prolonged efficacy in reducing tremors. Its mechanism of action makes it a valuable tool for research related to Alzheimer's disease and other cognitive disorders.

Cat. No.

A78764

CAS No.

2304818-41-3

BChE-IN-4

BChE-IN-4 is a potent butyrylcholinesterase (BChE) inhibitor that effectively crosses the blood-brain barrier. This compound has demonstrated the ability to attenuate learning and memory deficits associated with cholinergic deficits in mouse models. BChE-IN-4 shows promise for research applications related to Alzheimer's disease, making it a valuable tool for investigations into cognitive dysfunction and neurotransmitter modulation.

Cat. No.

A78765

CAS No.

1980064-35-4

Bleformin A

Bleformin A is a potent butyrylcholinesterase (BChE) inhibitor with an IC50 value of 5.2 μM. Isolated from the natural source Bletilla striata, this compound demonstrates significant biological activity that is relevant to neurodegenerative disorders. Bleformin A is primarily utilized in research related to Alzheimer's disease, providing insights into cholinergic system modulation.

Cat. No.

A78766

CAS No.

85802-28-4

Melineurine

Melineurine is a reversible mixed-type inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), exhibiting IC50 values of 95.3 μM for AChE and 28.0 μM for BChE. This compound is instrumental in the study of neurodegenerative disorders, particularly Alzheimer's disease, due to its effects on cholinergic signaling. Melineurine serves as a valuable tool for investigating the role of cholinesterase inhibition in cognitive function and related therapeutic strategies.

Cat. No.

A78767

CAS No.

3034673-37-2

SON38

SON38 is a copper chelator that selectively binds divalent copper ions. This compound exhibits inhibitory effects on cholinesterase activity, making it a valuable tool for research into Alzheimer's disease and related neurodegenerative disorders. Its ability to modulate copper levels underscores its potential in studying copper's role in various biological processes.

Cat. No.

A78768

CAS No.

95506-56-2

Fasciculin-II

Synonyms: Fas-2

Fasciculin-II is a potent inhibitor of acetylcholinesterase (AChE), an enzyme critical for neurotransmitter regulation. By blocking AChE activity, Fasciculin-II enhances cholinergic transmission, making it a valuable tool for research in neurobiology and related fields. Its biological activity is particularly relevant in studies of synaptic function and neurodegenerative diseases.

Cat. No.

A78769

CAS No.

2416910-82-0

AChE/BChE/MAO-B-IN-1

AChE/BChE/MAO-B-IN-1 is a reversible inhibitor targeting acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and monoamine oxidase B (MAO-B), exhibiting IC50 values of 7.31 μM, 0.56 μM, and 26.1 μM, respectively. This compound effectively crosses the blood-brain barrier and demonstrates neuroprotective properties while maintaining a lack of cytotoxicity. Its multifaceted inhibition profile makes it a valuable tool for research on neurodegenerative diseases and associated pathways.

Cat. No.

A78770

CAS No.

315210-31-2

MAO-A/B-IN-3

MAO-A/B-IN-3 is a dual inhibitor targeting both monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B), as well as acetylcholinesterase (AChE). With IC50 values of 67 nM for MAO-A, 29 nM for MAO-B, and 1370 nM for AChE, this compound demonstrates substantial multi-target efficacy. MAO-A/B-IN-3 modifies key binding sites to enhance its inhibitory activity against MAO enzymes while reducing the impact on AChE. This reagent is particularly relevant for research focused on neurodegenerative disorders.

Cat. No.

A78771

CAS No.

120012-04-6

Dihydro Donepezil

Synonyms: Dihydro E2020

Dihydro Donepezil is a potent cholinesterase (ChE) inhibitor, serving as a metabolite of Donepezil. It demonstrates significant biological activity, inhibiting acetylcholinesterase with IC50 values of 8.12 nM for bovine acetylcholinesterase (bAChE) and 11.6 nM for human acetylcholinesterase (hAChE). This compound is primarily utilized in research focused on neurodegenerative disorders and cognitive enhancement, contributing to studies on Alzheimer's disease and related pathways.

Cat. No.

A78772

CAS No.

2214210-63-4

AChE-IN-52

AChE-IN-52 is an acetylcholinesterase (AChE) inhibitor that demonstrates notable antitumor activity, particularly against breast cancer MCF-7 cells. This compound significantly disrupts amino acid metabolism and inhibits the migration of MCF-7 cells. Furthermore, AChE-IN-52 exerts its anticancer effects through the regulation of Best1 and HIST1H2BJ, making it a valuable tool for research in cancer biology and therapeutic development.

Cat. No.

A78774

CAS No.

6266-40-6

1,10-Bis(pyridinium)decane

Synonyms: Decamethylenebispyridinium dibromide

1,10-Bis(pyridinium)decane is a biscationic compound that acts as an acetylcholinesterase (AchE) inhibitor, demonstrating an IC50 of 25.8 nM. This reagent is valuable for research focused on neuropharmacology and the modulation of cholinergic signaling. Its specificity for AchE makes it suitable for studies investigating cognitive function and neurodegenerative diseases.

Cat. No.

A78776

CAS No.

412044-92-9

Ganstigmine hydrochloride

Synonyms: CHF 2819

Ganstigmine hydrochloride is an orally active inhibitor of acetylcholinesterase (AChE) that enhances the release of soluble amyloid precursor protein alpha (sAPPα) from neuroblastoma cells. This compound has been shown to increase acetylcholine levels in the prefrontal cortex of rats, making it a valuable tool in the study of cholinergic signaling. Ganstigmine hydrochloride is primarily utilized in research focused on neurological disorders, particularly Alzheimer's disease, to explore its implications in cognitive function and neuroprotection.

Cat. No.

A78777

CAS No.

2700896-73-5

BChE-IN-13

BChE-IN-13 is a potent and selective inhibitor of Butyrylcholinesterase (BChE), targeting both equine and human forms with IC50 values of 0.22 μM and 0.016 μM, respectively. This orally active compound demonstrates significant potential for enhancing memory and cognitive functions, making it a valuable tool in Alzheimer's disease research. Its specificity for BChE positions it as a promising candidate for exploring therapeutic strategies in neurodegenerative disorders.

Cat. No.

A78778

CAS No.

2410992-69-5

AChE/BChE-IN-3 hydrochloride

AChE/BChE-IN-3 hydrochloride is a dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), exhibiting IC50 values of 6.08 μM against electric eel AChE and 0.383 μM against equine serum BChE. This compound is valuable for research focused on neurodegenerative diseases and cholinergic dysfunction, providing insights into the modulation of cholinergic signaling pathways. Its potent inhibitory effects make it a useful tool for studying enzyme kinetics and drug discovery related to cognitive decline.

Cat. No.

A78779

CAS No.

145508-78-7

Icopezil

Synonyms: CP-118,954

Icopezil is a selective inhibitor of acetylcholinesterase (AchE), a key enzyme involved in the hydrolysis of acetylcholine. Its ability to enhance cholinergic transmission makes it a valuable compound for research in Alzheimer's disease and other cognitive disorders. By increasing acetylcholine levels in the synaptic cleft, Icopezil offers potential insights into therapeutic strategies targeting cholinergic deficits in neurodegenerative conditions.

Cat. No.

A78780

CAS No.

54063-52-4

Pitofenone

Pitofenone is a potent spasmolytic compound that primarily functions as an antispasmodic agent. It effectively inhibits acetylcholinesterase (AChE) activity in bovine erythrocytes and electric eel, exhibiting inhibition constants (Kis) of 36 μM and 45 μM, respectively. This compound is widely used in research applications focusing on muscle spasm relief and neuropharmacology.

Cat. No.

A78781

CAS No.

215319-47-4

(+)-Balanophonin (d-Balanophonin)

Synonyms: d-Balanophonin

(+)-Balanophonin is a phenolic compound that functions as an inhibitor of cholinesterase (ChE). It exhibits significant biological activities, including antioxidant, anti-inflammatory, anticancer, and antineurodegenerative effects. This compound is useful in research aimed at understanding neurodegenerative diseases and exploring potential therapeutic strategies for conditions associated with cholinergic system dysfunction.

Cat. No.

A78782

CAS No.

2185837-61-8

BChE-IN-10

BChE-IN-10 is a potent mixed-type inhibitor of butyrylcholinesterase (BChE), exhibiting an IC50 value of 6.4 μM. Isolated from Bletilla striata, this compound effectively modulates cholinergic activity and holds potential in the investigation of Alzheimer’s disease (AD) pathology. Its application in neurodegenerative research makes it a valuable tool for studying BChE-related mechanisms and therapeutic strategies.

Cat. No.

A78783

CAS No.

2140327-70-2

Acephate-d3

Acephate-d3 is a deuterated analogue of Acephate, serving as a stable isotope. This compound primarily acts as an anticholinesterase insecticide, exhibiting cholinotoxic effects. While it demonstrates weak inhibition of rat acetylcholinesterase (AChE), it exhibits potent inhibition of AChE in cockroaches, making it valuable for research in insect physiology and pest management studies.

Cat. No.

A78784

CAS No.

67600-94-6

Hydrangenol 8-O-glucoside

Synonyms: Hydrangenol 8-O-β-D-glucopyranoside

Hydrangenol 8-O-glucoside is an acetylcholinesterase (AChE) inhibitor, demonstrating an IC50 value of 22.66 μM. Isolated from Hydrangea macrophyllus, this compound exhibits significant activity in inhibiting the PCA (passive cutaneous anaphylaxis) reaction. Its properties make it a useful tool for research on neurodegenerative diseases and allergic responses.