Chelators & Bifunctional Chelators

Cat. No.

A41623

CAS No.

1800229-46-2

DOTA-GA-maleimide

DOTA-GA-maleimide is a bifunctional chelator that facilitates both protein conjugation and radiometal chelation. It forms stable complexes with indium-111 (111In) and utilizes maleimide chemistry for protein conjugation. This reagent enables the radiolabeling of LFn, which can be applied in imaging studies of matrix metalloproteinase (MMP) activity. DOTA-GA-maleimide is particularly useful in cancer research, offering valuable insights into tumor biology and therapeutic responses.

Cat. No.

A41630

CAS No.

2090232-34-9

NH2-PEG4-DOTA

NH2-PEG4-DOTA is a bifunctional chelator that effectively binds metal ions, including radionuclides, enabling the formation of radionuclide drug conjugates (RDCs). This compound is particularly useful for quantifying biological samples in conjunction with highly luminescent complexes. Additionally, NH2-PEG4-DOTA's ability to target specific biomolecules makes it suitable for applications in medical imaging and targeted radionuclide therapy.

Cat. No.

A41633

CAS No.

306776-79-4

DOTA-GA(tBu)4

DOTA-GA(tBu)4 is a bifunctional prochelator designed to enhance the stability of radiometals bound to ligands. This compound significantly improves the biodistribution of radiolabeled second-generation Affibody molecules by increasing their net negative charge, which reduces hepatic uptake and enhances tumor-to-blood and tumor-to-liver ratios. DOTA-GA(tBu)4 is particularly relevant for research involving HER2-positive breast and gastrointestinal cancers, facilitating targeted imaging and therapeutic applications.

Cat. No.

A41636

CAS No.

1639843-65-4

NH2 DOTA-GA

NH2 DOTA-GA is a bifunctional chelator based on the DOTA structure, designed for the preparation of radionuclide drug conjugates (RDCs). Its carboxylic acid groups facilitate the complexation of metal ions, such as Gd(III), making it a valuable tool in radiopharmaceutical development. NH2 DOTA-GA is suitable for applications in targeted imaging and therapy, enhancing the efficacy of radiolabeled agents in various biological research settings.

Cat. No.

A41639

CAS No.

1660127-21-8

p-NCS-Bz-NODA-GA

p-NCS-Bz-NODA-GA is a bifunctional chelating agent that forms stable complexes with metal ions, facilitating their identification and quantification. This compound exhibits excellent selectivity and stability, making it ideal for radiolabelling applications in molecular imaging and targeted therapy. Its unique properties allow for efficient metal ion capture in various biological contexts, enabling advanced research in biochemistry and molecular biology.

Cat. No.

A41641

CAS No.

913528-04-8

DOTAM-mono-acid

DOTAM-mono-acid is a chelator featuring a carboxylic acid group that enables the formation of amide bonds with the N-terminus of peptides. This compound facilitates the creation of peptide conjugates suitable for radiometal labeling, making it a valuable reagent in radiopharmaceutical development and peptide-based imaging studies. Its unique structure enhances the versatility of peptide modification for various biochemical applications.

Cat. No.

A41645

CAS No.

2125661-62-1

Butyne-DOTA

Butyne-DOTA is a bifunctional chelator (BFC) and a macrocyclic derivative of DOTA, designed for enhanced tumor pre-targeting applications. This compound facilitates the conjugation of peptides and radionuclides, making it a valuable tool in the development of targeted radiotherapy strategies. Its ability to form stable complexes with metal ions is essential for advancing research in molecular imaging and therapeutic interventions.

Cat. No.

A41650

CAS No.

2125661-54-1

Butyne-DOTA-tris(t-butyl ester)

Butyne-DOTA-tris(t-butyl ester) is a bifunctional chelator (BFC) and a macrocyclic DOTA derivative designed for tumor pre-targeting applications. This reagent facilitates the conjugation of peptides and radionuclides, enhancing the efficacy of targeted therapy in cancer research. Its structural properties make it suitable for developing imaging agents and therapeutic compounds in biomedical studies.

Cat. No.

A41651

CAS No.

1440903-11-6

MMA-NODAGA

MMA-NODAGA is a chelator designed for site-specific labeling of targeting proteins with unpaired cysteine residues. This reagent enables the conjugation of exosomes and facilitates the incorporation of 64Cu for applications in positron emission tomography (PET) imaging. Its ability to tag biomolecules provides valuable insights in research focused on molecular imaging and targeted therapies.

Cat. No.

A41655

CAS No.

2089035-56-1

NO2A-Butyne

NO2A-Butyne is a bifunctional chelator (BFC) and a macrocyclic NOTA derivative that facilitates tumor pre-targeting. This reagent is designed for the conjugation of peptides and radionuclides, enabling targeted delivery in cancer research applications. Its ability to stabilize complex formations highlights its utility in developing advanced imaging and therapeutic strategies.

Cat. No.

A41656

CAS No.

2435782-92-4

NO2A-Azide trihydrochloride

NO2A-Azide trihydrochloride is a bifunctional chelator that serves as a macrocyclic NOTA derivative, designed for tumor pre-targeting applications. This compound facilitates the conjugation of peptides and radionuclides, making it an essential tool in radiolabeling techniques. Its unique properties enable enhanced targeting and imaging of tumors in various research contexts, contributing significantly to the field of oncological studies.

Cat. No.

A41661

CAS No.

1397275-76-1

NOPO

NOPO is a bifunctional chelator designed for efficient binding to radionuclides. Its unique structure enables selective targeting of biomolecules, making it a valuable tool in both medical imaging and targeted therapy applications. NOPO's capacity to form stable complexes with radiolabeled agents enhances its utility in research focused on cancer imaging and treatment strategies.

Cat. No.

A41662

CAS No.

83834-39-3

NOTP

NOTP is a bifunctional chelator (BFC) and a macrocyclic derivative of NOTA, primarily utilized for tumor pre-targeting applications. Its unique structure allows for efficient conjugation with peptides and radionuclides, facilitating targeted delivery in cancer research. NOTP is instrumental in studies involving radiolabeled biomolecules for enhanced imaging and therapeutic strategies in oncology.

Cat. No.

A41664

CAS No.

1242003-07-1

TRAP

Synonyms: TRAP-Pr

TRAP is a bifunctional chelator designed to bind radionuclide [68]Ga, enabling specific targeting of biomolecules. This property makes TRAP suitable for applications in medical imaging and radiotherapy. Additionally, TRAP can be further modified with acetone, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for the conjugation of other labeled molecules in chemical research.

Cat. No.

A41665

CAS No.

2125661-91-6

NO2A-Butyne-bis(t-Butyl ester)

NO2A-Butyne-bis(t-Butyl ester) is a bifunctional chelator that targets tumor pre-targeting applications. As a macrocyclic NOTA derivative, it facilitates the conjugation of peptides and radionuclides. This reagent is essential for enhancing the specificity and efficacy of targeted imaging and therapeutic strategies in cancer research.

Cat. No.

A41671

CAS No.

2451069-30-8

TA-DOTA

TA-DOTA is a bifunctional chelator designed for the effective binding of radionuclides. This compound facilitates the conjugation of radionuclides to biomolecules, enabling targeted imaging and therapeutic applications in nuclear medicine. Its ability to selectively interact with biological targets enhances its utility in the development of radiopharmaceuticals.

Cat. No.

A41674

CAS No.

137076-50-7

DOTAEt

DOTAEt is a bifunctional chelator designed for efficient binding to radionuclides. This compound enables the conjugation of radionuclides to biomolecules, facilitating targeted imaging and therapeutic applications in medical research. DOTAEt's ability to selectively interact with specific biomolecules enhances its utility in the development of radiopharmaceuticals for diagnostic and therapeutic purposes.

Cat. No.

A41676

CAS No.

2166455-20-3

3p-C-NOTA

3p-C-NOTA is a bifunctional chelator designed for the specific binding of radionuclides. It demonstrates the ability to conjugate effectively with biomolecules, facilitating applications in medical imaging and targeted radiation therapy. This compound is essential for researchers exploring novel approaches in radiopharmaceutical development and molecular imaging techniques.

Cat. No.

A41677

CAS No.

1630114-57-6

NH2-NODAGA

NH2-NODAGA is a bifunctional chelator based on the NODAGA framework that effectively binds to radionuclides for the preparation of radionuclide conjugates (RDCs). This compound can react with diethyl squarate in a 0.5M phosphate buffer to yield NODAGA.SA, which is capable of targeting L-lysine urea-L-glutamate (KuE), an important component of prostate-specific membrane antigen (PSMA). The NODAGA.SA.KuE complex can be used for [68Ga] labeling, facilitating PET imaging in NMRInu/nu nude mice bearing LNCaP tumors, thereby advancing research in cancer diagnostics and therapy.

Cat. No.

A41678

CAS No.

2247041-83-2

2,3,5,6-Tetrafluorophenyl propionate-PEG3-amino-tetraxetan

2,3,5,6-Tetrafluorophenyl propionate-PEG3-amino-tetraxetan is a chelating agent and linker conjugate designed for the development of radiopharmaceuticals. This compound facilitates the attachment of metal ions to biomolecules, enhancing targeted delivery and imaging capabilities in biomedical research. Its unique structure may offer improved stability and bioavailability in various applications, making it suitable for scientific investigations in molecular imaging and therapeutic strategies.

Cat. No.

A41680

CAS No.

1924677-40-6

Propargyl-NOTA(tBu)2

Propargyl-NOTA(tBu)2 is a bifunctional chelator designed to effectively bind radionuclides for the preparation of radionuclide conjugates (RDCs). These conjugates enable specific targeting of biomolecules, making them valuable tools in medical imaging applications. The compound facilitates the development of advanced imaging agents that enhance the detection and characterization of various diseases.

Cat. No.

A41681

CAS No.

174137-97-4

NO2A-(t-Bu ester)

NO2A-(t-Bu ester) is a bifunctional chelator (BFC) and a macrocyclic NOTA derivative, primarily targeting tumor pre-targeting applications. This compound facilitates the conjugation of peptides and radionuclides, enhancing imaging and therapeutic strategies in oncology research. It is a valuable tool for developing targeted delivery systems within the realm of cancer treatment studies.

Cat. No.

A41682

CAS No.

2389064-47-3

DOTA(tBu3)-PEG4-TFP

DOTA(tBu3)-PEG4-TFP is a chelating agent-linker conjugate designed for applications in radiopharmaceutical synthesis. This compound facilitates the conjugation of biomolecules to radionuclides, enhancing the stability and efficacy of radiolabeled products. Its unique structure allows for increased biocompatibility and flexibility in the design of targeted radiotherapy agents, supporting a range of research applications in molecular imaging and therapeutics.

Cat. No.

A41683

CAS No.

161876-61-5

MAIPGG

MAIPGG is a bifunctional chelating agent that serves as an essential intermediate in the synthesis of radionuclide drug conjugates (RDCs). Its primary application lies in the radiolabeling of monoclonal antibodies with isotopes such as 99mTc and 186Re, facilitating radioimmunodetection and radioimmunotherapy in cancer research. This compound enables enhanced imaging and therapeutic approaches, contributing significantly to advancements in targeted oncology treatments.

Cat. No.

A41684

CAS No.

2685840-60-0

NH-CH2-CH2-DOTAM

NH-CH2-CH2-DOTAM is a bifunctional chelator that effectively binds to radionuclides, facilitating targeted delivery to biomolecules. This compound is primarily utilized in radionuclide conjugate applications for medical imaging and therapeutic interventions. Its ability to create stable radionuclide complexes enhances the specificity and efficacy of imaging techniques and targeted therapies in biomedical research.