Cysteine Protease

Cat. No.

A13593

CAS No.

147859-80-1

CA-074 Methyl Ester

Synonyms: CA-074 Me

CA-074 methyl ester is a cell-permeable analog of CA-074 that acts as an irreversible cathepsin B inhibitor. CA-074 methyl ester is reported to inhibit bone resorption in rodent models and shown to inhibit B16 melanoma cell invasion in vitro.

Cat. No.

A13259

CAS No.

88321-09-9

Aloxistatin (E 64d)

Synonyms: E-64d

E-64d is an inhibitor of cathepsins B and L and it is lysosome and cell permeable.

Cat. No.

A13502

CAS No.

907559-59-5

Z-FL-COCHO (LY3000328)

Synonyms: Cathepsin S inhibitor; LY3000328

Z-FL-COCHO (LY3000328) is a novel Cathepsin S inhibitor.  

Cat. No.

A13256

CAS No.

134448-10-5

CA-074

CA-074 is a potent inhibitor of cathepsin B with a Ki of 2 to 5 nM.

Cat. No.

A15303

CAS No.

88191-84-8

MDL 28170

Synonyms: Calpain Inhibitor III

MDL 28170 is a cell permeable selective inhibitor of Calpain 1, a Ca2+-dependent cysteine protease which has been implicated in apoptosis of immune cells as well as neuronal cells.

Cat. No.

A15306

CAS No.

179528-45-1

PD 150606

PD 150606 is a cell-permeable, non-competitive, selective, non-peptide Ca2+ dependent calpain inhibitor for calpain-1 and for calpain-2 directed towards the Ca2+ binding sites of calpain.

Cat. No.

A21069

CAS No.

1310340-58-9

VBY-825

VBY-825 is a novel, reversible cathepsin inhibitor with high potency against cathepsins B, L, S and V.

Cat. No.

A11265

CAS No.

603139-19-1

Odanacatib (MK-0822)

Synonyms: MK0822

Odanacatib is an inhibitor of cathepsin K,an enzyme involved in bone resorption.

Cat. No.

A11466

CAS No.

225120-65-0

Cathepsin Inhibitor 1

Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.

Cat. No.

A12020

CAS No.

354813-19-7

Balicatib

Synonyms: AAE581; AAE-581,AAE 581

Balicatib, a cathepsin K inhibitor, stimulates periosteal bone formation in monkeys.

Cat. No.

A12487

CAS No.

603139-12-4

L-873724

L-873724 is a potent, orally bioavailable, selective and reversible non-basic cathepsin K inhibitor.

Cat. No.

A13257

CAS No.

66701-25-5

E-64

E-64 is an irreversible and selective cysteine protease inhibitor with IC50 of 9 nM for papain.

Cat. No.

A13258

CAS No.

76684-89-4

Loxistatin Acid (E64-C)

Synonyms: NSC 694279; EP 475,E-64C; E64-C

Loxistatin Acid, a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor.

Cat. No.

A13394

CAS No.

1252637-35-6

Petesicatib

Petesicatib is a cathepsin S inhibitor, used in research of immune diseases.

Cat. No.

A13611

CAS No.

21438-66-4

Gly-Phe-beta-naphthylamide

Synonyms: H-Gly-Phe-BNA

Gly-Phe-beta-naphthylamide is a cathepsin C substrate. The compound is described to accumulate inside lysosomes leading to their destruction.

Cat. No.

A13640

CAS No.

190274-53-4

SJA6017

Synonyms: Calpain Inhibitor VI

SJA6017 is a cell permeable peptide aldehyde which functions as a reversible calpain inhibitor.

Cat. No.

A14145

CAS No.

103476-89-7

Leupeptin hemisulfate

Leupeptin hemisulfate is a reversible inhibitor of trypsin-like and cysteine proteases such as calpain.

Cat. No.

A14220

CAS No.

110044-82-1

MG-101

Synonyms: ALLN

MG-101 (ALLN) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.

Cat. No.

A14245

CAS No.

179461-52-0

(Rac)-PD 151746

Synonyms: PD-151746

PD 151746 is a selective, cell-permeable calpain inhibitor with Ki of 0.26 uM for μ-Calpain, about 20-fold selectivity over m-calpain.

Cat. No.

A14284

CAS No.

197855-65-5

Z-FA-FMK

Z-FA-FMK is an irreversible cysteine protease inhibitor.

Cat. No.

A14911

CAS No.

136632-32-1

Calpain Inhibitor II, ALLM

Calpain Inhibitor II, ALLM is a cell-permeable inhibitor of calpain I, calpain II, cathepsin L and cathepsin B with Ki values of 120 nM, 230 nM, 0.6 nM and 100 nM, respectively.

Cat. No.

A15290

CAS No.

123714-50-1

Acetyl-Calpastatin (184-210) (human)

Acetyl-Calpastatin (184-210) (human), selective calpain inhibitor. Strongly inhibits calpain I (Ki = 0.2 nM) and II but does not inhibit papain, trypsin and cathepsin L (Ki = 6 uM). Increases secretion of amyoid β-protein (Aβ) 42, Aβ40 and Aβ42 ratio.

Cat. No.

A15295

CAS No.

117591-20-5

Calpeptin

Calpeptin is a cell permeable calpain inhibitor.

Cat. No.

A15302

CAS No.

294623-49-7

L 006235

L006235 is a potent, reversible cathepsin K inhibitor (IC50 = 0.25 nM) that displays > 4000-fold selectivity over cathepsins B, L and S.

Cat. No.

A15313

CAS No.

958772-66-2

SID 26681509

SID 26681509 is a reversible and potent human cathepsin L inhibitor. SID 26681509 displays no inhibitory activity of cathepsin G.