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HCV Protease

Hepatitis C virus (HCV) protease inhibitors act on the nonstructural protein 3-4A (NS3-4A) serine protease. The HCV genome was identified in 1989 from a blood-borne non-A, non-B hepatitis agent. Its polyprotein is cleaved by NS3-4A, so inhibitors of that protease block maturation of the other viral proteins. Telaprevir, boceprevir, asunaprevir, danoprevir and grazoprevir are NS3-4A inhibitors from several chemical series with differing binding modes. Compounds directed at other replication steps are listed alongside them, because they are used in the same assays. Daclatasvir, reported in 2010 as an inhibitor of the nonstructural protein 5A (NS5A) phosphoprotein, and ledipasvir (GS 5885) belong to that group. Proteases of other viruses and families appear under the sibling categories HIV Protease and Serine Protease.

Items 1-25 of 97

  • Telaprevir
    Cat. No.
    A10902
    CAS No.
    402957-28-2

    Telaprevir (VX-950)

    Synonyms: VX950; Incivek; Incivo

    Telaprevir (VX-950) is known as protease inhibitors that inhibits the hepatitis C virus NS3.4A serine protease.

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    1 mg
    $35.00
    2 mg
    $55.00
    All 8 sizes
  • Danoprevir
    Cat. No.
    A10284
    CAS No.
    850876-88-9

    Danoprevir (RG7227)

    Synonyms: ITMN-191; RO5190591; RG7227

    Danoprevir is a potent inhibitor of the HCV NS3/4A serine protease.

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    1 mg
    $50.00
    2 mg
    $55.00
    All 8 sizes
  • Daclatasvir
    Cat. No.
    A10159
    CAS No.
    1009119-64-5

    Daclatasvir (BMS-790052)

    Synonyms: BMS-790052

    BMS-790052 is an NS5A inhibitor under investigation for the treatment of hepatitis C virus (HCV) infection.

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    5 mg
    $30.00
    10 mg
    $40.00
    All 7 sizes
  • Cis-Lomibuvir
    Cat. No.
    A10980
    CAS No.
    1026785-59-0

    Cis-Lomibuvir (cis-VX-222)

    Synonyms: VCH222; VX222; cis-VX-222

    VX-222 is a small molecule non-nucleoside inhibitor of HCV NS5B polymerase that is being investigated for the treatment of hepatitis C virus infection.

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    5 mg
    $100.00
    10 mg
    $190.00
    All 6 sizes
  • Grazoprevir
    Cat. No.
    A17303
    CAS No.
    1350514-68-9

    Grazoprevir

    Synonyms: MK-5172

    Grazoprevir (MK-5172) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Kis of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively.

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    1 mg
    $35.00
    2 mg
    $50.00
    All 9 sizes
  • Anguizole
    Cat. No.
    A11294
    CAS No.
    442666-98-0

    Anguizole

    Anguizole is a small molecule inhibits HCV replication and alters NS4B's subcellular distribution.

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    2 mg
    $50.00
    5 mg
    $85.00
    All 5 sizes
  • BMS-790052 2HCl
    Cat. No.
    A11336
    CAS No.
    1009119-65-6

    BMS-790052 2HCl

    Synonyms: BMS790052

    BMS-790052 is an NS5A inhibitor under investigation for the treatment of hepatitis C virus (HCV) infection.

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    5 mg
    $30.00
    10 mg
    $35.00
    All 8 sizes
  • PSI-6130
    Cat. No.
    A11519
    CAS No.
    817204-33-4

    PSI-6130

    Synonyms: R 1656

    PSI-6130(R 1656) is a Hepatitis C Virus Nucleoside Inhibitor.

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    1 mg
    $50.00
    2 mg
    $95.00
    All 8 sizes
  • Sofosbuvir
    Cat. No.
    A11529
    CAS No.
    1190307-88-0

    Sofosbuvir (PSI-7977)

    Synonyms: GI-7977; PSI-7977

    PSI-7977 is a phosphoramidate prodrug of PSI-7851, a nucleoside analog that, when phosphorylated, inhibits the RNA-dependent RNA polymerase of hepatitis C virus (EC50 = 92 nM).

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    5 mg
    $40.00
    10 mg
    $50.00
    All 8 sizes
  • VCH-759
    Cat. No.
    A15479
    CAS No.
    1001913-13-8

    VCH-759

    VCH-759 is a non-nucleoside inhibitor of HCV RNA-dependent polymerase with sub-micromolar IC50 values versus genotype 1a/1b replicons.

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    5 mg
    $150.00
    10 mg
    $250.00
    All 3 sizes
  • Ribavirin
    Cat. No.
    A10788
    CAS No.
    36791-04-5

    Ribavirin

    Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV.

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    50 mg
    $30.00
    100 mg
    $40.00
    All 5 sizes
  • Balapiravir
    Cat. No.
    A11335
    CAS No.
    690270-29-2

    Balapiravir (R1626)

    Synonyms: R-1626; Ro 4588161

    Balapiravir (R1626, RG1626) is the prodrug of a nucleoside analogue inhibitor of the hepatitis C virus (HCV) RNA-dependent RNA polymerase (R1479, RG1479).

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    2 mg
    $105.00
    5 mg
    $195.00
    All 5 sizes
  • Narlaprevir
    Cat. No.
    A11506
    CAS No.
    865466-24-6

    Narlaprevir

    Synonyms: SCH 900518

    Narlaprevir is a potent, selective, orally bioavailable NS3 protease inhibitor(Ki=6 nM; EC90=40 nM)

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    2 mg
    $200.00
    5 mg
    $320.00
    All 5 sizes
  • Nesbuvir
    Cat. No.
    A11510
    CAS No.
    691852-58-1

    Nesbuvir

    Synonyms: HCV 796

    HCV-796 is a selectively inhibitor of hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase.

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    1 mg
    $90.00
    5 mg
    $225.00
    All 8 sizes
  • PSI-6206
    Cat. No.
    A11530
    CAS No.
    863329-66-2

    PSI-6206

    Synonyms: GS-331007; RO-2433

    PSI-6206 is the deaminated derivative of PSI-6130, which is a potent inhibitor of hepatitis C virus (HCV) replication in the subgenomic HCV reolicon system.

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    5 mg
    $25.00
    10 mg
    $25.00
    All 7 sizes
  • Mericitabine
    Cat. No.
    A11539
    CAS No.
    940908-79-2

    Mericitabine

    Synonyms: RG 7128; R-7128; PSI 6130 diisobutyrate

    Mericitabine (RG 7128; R-7128) is a nucleoside inhibitor of the HCV NS5B polymerase that acts as an RNA chain terminator and prevents elongation of RNA transcripts during replication.

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    1 mg
    $40.00
    5 mg
    $105.00
    All 8 sizes
  • R-1479
    Cat. No.
    A11540
    CAS No.
    478182-28-4

    R-1479

    Synonyms: 4'-Azidocytidine

    R-1479 is a specific inhibitor of HCV replication in the HCV subgenomic replicon system (IC50=1.28 μM).

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    1 mg
    $130.00
    2 mg
    $190.00
    All 8 sizes
  • Simeprevir
    Cat. No.
    A11580
    CAS No.
    923604-59-5

    Simeprevir

    Synonyms: TMC435; TMC435350

    Simeprevir is a potent inhibitor of HCV NS3/4A protease (Ki = 0.36 nM) and viral replication (replicon EC50 = 7.8 nM).

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    2 mg
    $25.00
    5 mg
    $40.00
    All 7 sizes
  • Vaniprevir
    Cat. No.
    A11600
    CAS No.
    923590-37-8

    Vaniprevir

    Synonyms: MK-7009

    Vaniprevir is a non-covalent competitive inhibitor of the hepatitis C virus (HCV) NS3/4A protease.

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    5 mg
    $1,050.00
    10 mg
    $1,800.00
    All 4 sizes
  • Voxilaprevir
    Cat. No.
    A12067
    CAS No.
    1535212-07-7

    Voxilaprevir

    Synonyms: GS-9857

    Voxilaprevir (GS-9857) is a fluorinated macrocyclic hepatitis C virus (HCV) nonstructural protein (NS) 3/4A protease inhibitor with potent in vitro antiviral activity against genotypes 1-6 HCV and broad coverage of NS3/4A protease polymorphisms. GS-9857 improves coverage against commonly encountered NS3 resistance-associated variants (RAVs).

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    1 mg
    $80.00
    5 mg
    $385.00
    All 8 sizes

Items 1-25 of 97

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