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Protein Tyrosine Phosphatase

Protein tyrosine phosphatase (PTP) inhibitors block enzymes that remove phosphate groups from tyrosine residues. PTPs counterbalance tyrosine kinases, and the classical PTPs share a catalytic cysteine within a conserved active-site motif. Mice lacking PTP1B show increased insulin sensitivity, which made this enzyme a model target in metabolic signaling research. SHP099 and SHP394 are allosteric inhibitors of Src homology 2 domain-containing phosphatase 2 (SHP2), which relays signals from receptor tyrosine kinases. NSC 87877 acts at the catalytic sites of SHP1 and SHP2, and TCS 401 free base inhibits PTP1B. Alexidine dihydrochloride inhibits PTP localized to the mitochondrion 1 (PTPMT1), a phosphatase located in the inner mitochondrial membrane.

Items 151-152 of 152

  • SHP1 activator 1
    Cat. No.
    A84720
    CAS No.
    3113070-25-7

    SHP1 activator 1

    SHP1 Activator 1 is a potent activator of src homology-2 domain-containing protein tyrosine phosphatase 1 (SHP1), exhibiting an EC50 of 17.66 μM. This compound has demonstrated efficacy in inhibiting the proliferation of ABC-DLBCL cells and inducing apoptosis by targeting the STAT3 signaling pathway. Additionally, SHP1 Activator 1 emits blue and green fluorescence signals in MDA-MB-231 cells, making it suitable for use as a cell imaging agent in research applications.

    In stock View Details
    5 mg
    $125.00
    10 mg
    $210.00
    All 5 sizes
  • SHP2-IN-37
    Cat. No.
    A84721
    CAS No.
    3086289-71-3

    SHP2-IN-37

    SHP2-IN-37 is a potent allosteric inhibitor of SHP2, demonstrating a selective binding profile with an IC50 of 0.023 μM. This compound exhibits significant antiproliferative effects on KYSE-520 and MV-411 cancer cell lines, with IC50 values of 6.97 μM and 0.67 μM, respectively. SHP2-IN-37 is valuable for research focused on the modulation of SHP2 signaling pathways and the development of targeted therapies in various cancer models.

    In stock View Details
    5 mg
    $670.00
    10 mg
    $1,110.00
    All 4 sizes

Items 151-152 of 152

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