Protein Tyrosine Phosphatase

Cat. No.

A36363

CAS No.

3033936-66-9

PTPN2-IN-1

PTPN2-IN-1 is a potent inhibitor of Protein Tyrosine Phosphatase N2 (PTPN2) with an IC50 of ≤5 μM. This compound has demonstrated efficacy in inhibiting cell growth in B16F10 melanoma cells, making it a valuable tool for research in cancer biology. Its specific target engagement provides insights into the regulatory roles of PTPN2 in cellular signaling pathways and potential therapeutic applications.

Cat. No.

A36378

CAS No.

1146616-14-9

VHR-IN-2

VHR-IN-2 is a selective inhibitor of the vaccinia H1-related phosphatase (VHR), demonstrating an IC50 of 3.1 μM. This compound is primarily utilized in research focused on cervical cancer, where VHR plays a significant role in tumor progression and pathology. VHR-IN-2 serves as an important tool for elucidating the biological functions of VHR and exploring its potential as a therapeutic target.

Cat. No.

A36381

CAS No.

2948339-38-4

Anticancer agent 143

Anticancer agent 143 is a dual inhibitor of PTPN2 and PTP1B, demonstrating potent bioactivity with IC50 values of less than 2.5 nM. This compound is valuable for cancer research, providing insights into the roles of these protein tyrosine phosphatases in tumor biology and potential therapeutic strategies.

Cat. No.

A36387

CAS No.

2848581-86-0

PTP1B-IN-16

PTP1B-IN-16 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B), exhibiting a Ki value of 12.6 μM. This benzimidazole derivative is primarily utilized in research focused on type 2 diabetes. By inhibiting PTP1B, this compound may contribute to the modulation of insulin signaling pathways, thereby providing insights into potential therapeutic strategies for metabolic disorders.

Cat. No.

A36388

CAS No.

3112461-52-3

PTPN2-IN-3

PTPN2-IN-3 is a selective inhibitor of Protein Tyrosine Phosphatase Non-Receptor Type 2 (PTPN2), which plays a critical role in regulating cellular signaling pathways and immune responses. This compound has demonstrated potential in modulating tumor progression and is suitable for research applications focused on cancer biology and therapeutic development. Its ability to influence PTPN2 activity provides valuable insights into tumor microenvironment interactions and immune evasion mechanisms.

Cat. No.

A36392

CAS No.

84323-14-8

Albafuran A

Albafuran A is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B), which plays a key role in regulating insulin signaling pathways. This compound exhibits significant biological activity in modulating glucose metabolism and may serve as a valuable tool in the study of type 2 diabetes and obesity. Its inhibitory effects on PTP1B make it particularly relevant for investigations into therapeutic strategies targeting metabolic disorders.

Cat. No.

A36393

CAS No.

27214-72-8

Cyanidin 3-arabinoside

Cyanidin 3-arabinoside is a selective and reversible inhibitor of protein tyrosine phosphatase 1B (PTP1B), exhibiting an IC50 value of 8.91 μM. It has demonstrated potential for research applications related to type 2 diabetes, offering insights into metabolic regulation and therapeutic strategies.

Cat. No.

A36398

CAS No.

2097148-94-0

LXQ46

LXQ46 is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B), with an IC50 value of 0.190 μM. This compound has been shown to enhance insulin and leptin signaling pathways in insulin-resistant C2C12 cells, demonstrating its ability to improve metabolic function. LXQ46 has potential applications in type 2 diabetes research, evidenced by its effectiveness in increasing insulin tolerance in various mouse models.

Cat. No.

A36402

CAS No.

2848581-84-8

PTP1B-IN-18

PTP1B-IN-18 is an orally active mixed-type inhibitor of protein tyrosine phosphatase 1B (PTP1B), exhibiting a Ki of 35.2 μM. This compound is utilized in research focused on type 2 diabetes, where it is investigated for its potential to modulate insulin signaling pathways and improve glucose homeostasis. Its role as a PTP1B inhibitor makes it a valuable tool for understanding the molecular mechanisms underlying diabetes and related metabolic disorders.

Cat. No.

A36404

CAS No.

82508-34-7

Methyl pseudolarate B

Methyl pseudolarate B is a natural diterpenoid that serves as an inhibitor of protein tyrosine phosphatase 1B (PTP1B) with an IC50 value of 10.9 μM. This compound is significant in the study of insulin signaling and metabolic disorders, making it a valuable tool for research applications focused on diabetes and obesity. Its inhibition of PTP1B can help elucidate mechanisms underlying cellular signaling pathways.

Cat. No.

A36407

CAS No.

1403406-29-0

IONIS PTP1BRx

Synonyms: ISIS 404173

IONIS PTP1BRx is an antisense inhibitor specifically targeting protein tyrosine phosphatase 1B (PTP-1B). This compound exhibits notable antidiabetic activity, making it valuable for research into insulin resistance and the mechanisms underlying type 2 diabetes mellitus, particularly in the context of obesity. Its selective inhibition of PTP-1B allows for a deeper understanding of metabolic dysregulation and potential therapeutic interventions.

Cat. No.

A36416

CAS No.

1146616-18-3

VHR-IN-9

VHR-IN-9 is a selective inhibitor of vaccinia H1-related (VHR) phosphatase, exhibiting an IC50 of 270 nM. This compound demonstrates limited inhibitory activity on other phosphatases, such as MKP-1 (IC50 = 2.8 μM) and CD45 (IC50 = 1.8 μM). VHR-IN-9 effectively inhibits the proliferation of HeLa cells, making it a valuable reagent for research focused on cervical cancer.

Cat. No.

A36417

CAS No.

1402543-98-9

Arhododendric acid A

Arhododendric acid A is a triterpenoid that acts as a selective inhibitor of the protein tyrosine phosphatase PTP1B, exhibiting an IC50 of 6.3 μM. This compound plays a significant role in the modulation of insulin signaling pathways and is primarily utilized in research relevant to type 2 diabetes. Its inhibition of PTP1B supports investigations into glucose metabolism and insulin resistance, making it a valuable reagent for diabetes-related studies.

Cat. No.

A36421

CAS No.

1085706-32-6

cis-Emodin-physcion bianthrone

cis-Emodin-physcion bianthrone is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B), demonstrating an IC50 value of 7.29 μM. This compound is crucial for research related to type 2 diabetes, where modulation of PTP1B activity may influence insulin signaling pathways and glucose homeostasis. Its inhibitory effects make it a valuable tool for investigating therapeutic strategies in metabolic disorders.

Cat. No.

A36424

CAS No.

1085706-33-7

trans-Emodin-physcion bianthrone

trans-Emodin-physcion bianthrone is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B), exhibiting an IC50 value of 2.77 μM. This compound plays a significant role in research focused on insulin resistance and metabolic diseases, making it a valuable tool for investigating potential therapeutic strategies in glucose homeostasis and diabetes management. Its mechanism of action may provide insights into the modulation of insulin signaling pathways.

Cat. No.

A36427

CAS No.

956442-05-0

VHR-IN-5

VHR-IN-5 is a selective inhibitor of vaccinia H1-related phosphatase (VHR) with an IC50 value of 78 nM, demonstrating significant inhibition while exhibiting weaker effects against other phosphatases such as MKP-1 and CD45. This compound effectively inhibits HeLa cell proliferation, making it a valuable tool for investigating cervical cancer mechanisms. Its specificity for VHR highlights its potential for research applications in cancer biology and therapeutic development.

Cat. No.

A36436

CAS No.

1146616-15-0

VHR-IN-4

VHR-IN-4 is a selective inhibitor of vaccinia H1-related phosphatase (VHR), exhibiting an IC50 of 1.8 μM. This compound demonstrates potent activity in the inhibition of VHR, making it a valuable tool for investigating its role in cervical cancer. VHR-IN-4 is suitable for research applications aimed at elucidating the biochemical pathways associated with this phosphatase and its implications in cancer biology.

Cat. No.

A36437

CAS No.

1146616-19-4

VHR-IN-8

VHR-IN-8 is a selective inhibitor of vaccinia H1-related phosphatase (VHR) with an IC50 value of 2.4 μM. It demonstrates significant potential in the study of cervical cancer, providing valuable insights into the molecular mechanisms underlying tumor progression. This compound serves as a critical tool for researchers investigating the role of phosphatases in cancer biology and therapeutic development.

Cat. No.

A36439

CAS No.

1256341-22-6

CX08005

CX08005 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B), functioning through competitive inhibition to enhance insulin signaling pathways. This reagent demonstrates significant effects in both in vivo and in vitro models by improving insulin sensitivity and mitigating insulin resistance. CX08005 is applicable in research focused on metabolic disorders and diabetes-related studies.

Cat. No.

A36441

CAS No.

77500-30-2

PTP1B-IN-33

PTP1B-IN-33 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B) with a human IC50 of 2.45 μM, exhibiting over 20-fold selectivity for PTP1B relative to SHP2. By enhancing π-Alkyl interactions, it promotes a higher degree of closure in the WPD loop, facilitating more effective inhibition of PTP1B activity. This compound is valuable for research into cancer, diabetes, and autoimmune deficiency diseases, providing insights into therapeutic strategies targeting PTP1B-mediated pathways.

Cat. No.

A36448

CAS No.

151606-30-3

Dephostatin

Dephostatin is a competitive inhibitor of protein tyrosine phosphatases (PTPs) derived from Streptomyces species. It demonstrates micromolar-level activity, making it a valuable tool for investigating PTP function and signaling pathways. Dephostatin is widely used in research applications related to cell signaling, cancer biology, and metabolic regulation.

Cat. No.

A36460

CAS No.

1443442-61-2

CG-707

CG-707 is a potent inhibitor of phosphatase of regenerating liver-3 (PRL-3), exhibiting an IC50 value of 0.8 μM. This compound effectively prevents the migration and invasion of colon cancer cells that overexpress PRL-3, highlighting its potential for use in cancer research and therapy targeting PRL-3 mediated processes. CG-707 serves as a valuable tool for investigating the role of PRL-3 in tumor progression and metastasis.

Cat. No.

A36464

CAS No.

29936-81-0

4-(Bromoacetyl)phenoxyacetic acid

4-(Bromoacetyl)phenoxyacetic acid is a selective inhibitor of protein tyrosine phosphatases (PTPs). This compound exhibits significant biological activity in modulating PTP-mediated signaling pathways, making it valuable for studying cellular processes involving protein phosphorylation. Its application extends to research focused on cancer, diabetes, and immune system regulation, where PTP activity plays a critical role.

Cat. No.

A36470

CAS No.

1444618-61-4

Dehydrodanshenol A

Dehydrodanshenol A is a non-competitive inhibitor of Protein Tyrosine Phosphatase 1B (PTP1B), demonstrating an IC50 value of 8.5 μM. This compound is valuable for investigations related to diabetes and metabolic disorders, as it plays a role in modulating insulin signaling pathways. Researchers may utilize Dehydrodanshenol A to further understand PTP1B's role in glucose homeostasis and its potential as a therapeutic target.

Cat. No.

A76734

CAS No.

148089-70-7

S-15176

S-15176 is a potent inhibitor of the mitochondrial permeability transition pore (PTP). It effectively prevents mitochondrial swelling induced by tert-butylhydroperoxide with an IC50 of 45.7 μM. S-15176 inhibits PTP opening, preserves mitochondrial membrane potential, and enhances NAD(P)H oxidation, while increasing the mitochondrial calcium loading capacity. This compound holds potential for research in ischemia-reperfusion injury and related mitochondrial dysfunctions.