JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.

E3 Ligase Ligands

E3 ligase ligands bind ubiquitin ligases such as cereblon and von Hippel-Lindau (VHL) in degrader design. In a degrader, they anchor the ligase end of the molecule. E3 ubiquitin ligases transfer ubiquitin to substrate proteins and mark them for degradation by the proteasome. Thalidomide and its analogs bind cereblon (CRBN), a substrate receptor of a cullin-based E3 ligase complex identified as their direct target in 2010. The category includes cereblon ligands such as thalidomide fluoride and TD-106, and VHL ligands such as VL285 and VH032-cyclopropane-F. These ligands are used to build proteolysis-targeting chimeras (PROTACs) and to study how ligases are recruited to new substrates.

Cat. No.

A80797

CAS No.

2925082-31-9

CRBN ligand-588

CRBN ligand-588 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of the cereblon protein in targeted protein degradation applications. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). Its use in research promotes advancements in the development of targeted therapies through the modulation of protein levels in various biological contexts.

View Details

Out of stock
All 3 sizes
Cat. No.

A80798

CAS No.

2925071-06-1

CRBN ligand-643

CRBN ligand-643 is a ligand designed to target the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. It can be conjugated with a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). This compound is valuable for research applications focusing on targeted protein degradation and the modulation of cellular pathways.

View Details

Out of stock
All 3 sizes
Cat. No.

A80799

CAS No.

2925093-72-5

CRBN ligand-540

CRBN ligand-540 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of the CRBN protein. This compound is pivotal for the construction of PROTACs by enabling the linkage of target protein ligands through a suitable spacer. Its utility extends to targeted protein degradation studies, contributing to the exploration of protein regulation and therapeutic interventions in various biological contexts.

View Details

Out of stock
All 3 sizes
Cat. No.

A80800

CAS No.

1499388-70-3

Hydrouracil-(4-Br-2,6-difluorobenzene)

Hydrouracil-(4-Br-2,6-difluorobenzene) serves as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated with target protein ligands through linkers to create PROTAC molecules, which are pivotal in targeted protein degradation research. Its application in the development of novel therapeutic strategies highlights its significance in chemical biology and drug discovery.

In stock View Details

5 mg

$30.00

10 mg

$40.00

All 4 sizes
Cat. No.

A80801

CAS No.

2925089-83-2

CRBN ligand-357

CRBN ligand-357 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of cereblon, enabling targeted protein degradation when conjugated with a proximal ligand through a linker. This compound is valuable for researchers studying protein homeostasis and developing PROTACs for applications in targeted cancer therapies and other signaling pathways.

View Details

Out of stock
All 3 sizes
Cat. No.

A80802

CAS No.

2925102-28-7

CRBN ligand-336

CRBN ligand-336 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of the CRBN protein to target proteins, enabling the design of proteolysis-targeting chimeras (PROTACs). This compound is essential for studies focused on targeted protein degradation and can be utilized in various research applications involving protein manipulation and regulation.

View Details

Out of stock
All 3 sizes
Cat. No.

A80803

CAS No.

2925091-28-5

CRBN ligand-261

CRBN ligand-261 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), which facilitates the recruitment of CRBN to target proteins. This compound can be utilized in the design of PROTACs (proteolysis-targeting chimeras) by linking it to a target protein ligand through a suitable linker. Its applications in chemical biology include targeted degradation of specific proteins, thereby advancing research in drug development and protein homeostasis.

View Details

Out of stock
All 3 sizes
Cat. No.

A80804

CAS No.

2925102-83-4

CRBN ligand-548

CRBN ligand-548 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be utilized to form proteolysis-targeting chimeras (PROTACs) by linking it to a target protein ligand via a suitable linker. Its application in targeted protein degradation research makes it a valuable tool for studying protein homeostasis and therapeutic interventions.

View Details

Out of stock
All 3 sizes
Cat. No.

A80805

CAS No.

2633726-34-6

Hydrouracil-(4-CP)

Hydrouracil-(4-CP) is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN in targeted protein degradation applications. This compound can be conjugated to a specific target protein ligand through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimeras). Hydrouracil-(4-CP) is instrumental in studies focusing on selective protein degradation and cellular protein turnover.

View Details

Out of stock
All 3 sizes
Cat. No.

A80806

CAS No.

2925092-69-7

CRBN ligand-497

CRBN ligand-497 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be coupled with a ligand for a target protein through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). CRBN ligand-497 is utilized in research to explore targeted protein degradation pathways and to study the role of the ubiquitin-proteasome system in cellular regulation.

View Details

Out of stock
All 3 sizes
Cat. No.

A80807

CAS No.

2925072-70-2

CRBN ligand-605

CRBN ligand-605 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound effectively recruits the cereblon protein, facilitating the formation of PROTAC molecules when linked to target protein ligands. CRBN ligand-605 is primarily utilized in studies involving targeted protein degradation, enabling researchers to explore therapeutic applications in cancer and other diseases.

View Details

Out of stock
All 3 sizes
Cat. No.

A80808

CAS No.

2925069-87-8

CRBN ligand-529

CRBN ligand-529 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). CRBN ligand-529 is essential for studies involving targeted protein degradation and the investigation of cellular pathways influenced by ubiquitin-mediated proteolysis.

View Details

Out of stock
All 3 sizes
Cat. No.

A80809

CAS No.

2925093-84-9

CRBN ligand-293

CRBN ligand-293 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be coupled with a target protein ligand through a linker to create a proteolysis targeting chimera (PROTAC). CRBN ligand-293 is essential for research applications aimed at studying targeted protein degradation and modulating cellular pathways.

View Details

Out of stock
All 3 sizes
Cat. No.

A80810

CAS No.

2925073-20-5

CRBN ligand-602

CRBN ligand-602 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this protein to target substrates. This compound can be utilized in the development of PROTACs (proteolysis-targeting chimeras) by linking it to a target protein ligand through a suitable linker. Its utility in targeted protein degradation makes it a valuable tool for researchers interested in modulating protein levels in cellular systems.

View Details

Out of stock
All 3 sizes
Cat. No.

A80811

CAS No.

2925100-01-0

CRBN ligand-758

CRBN ligand-758 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized to link target protein ligands through a suitable linker, enabling the formation of PROTACs (proteolysis targeting chimeras). CRBN ligand-758 offers significant potential for applications in targeted protein degradation research and the development of novel therapeutic strategies.

View Details

Out of stock
All 3 sizes
Cat. No.

A80812

CAS No.

2925081-03-2

CRBN ligand-456

CRBN Ligand-456 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. It is designed for use in the development of PROTACs by linking to target protein ligands through a suitable linker. This compound plays a crucial role in studying protein degradation pathways and offers potential in therapeutic applications involving targeted protein modulation.

View Details

Out of stock
All 3 sizes
Cat. No.

A80813

CAS No.

2925072-55-3

CRBN ligand-442

CRBN ligand-442 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to target protein ligands through a linker to create a proteolysis-targeting chimera (PROTAC). Its application in targeted protein degradation makes it valuable for studying protein dynamics and potential therapeutic interventions.

View Details

Out of stock
All 3 sizes
Cat. No.

A80814

CAS No.

444287-84-7

Pomalidomide-COCH2Cl

Pomalidomide-COCH2Cl is a derivative of Pomalidomide featuring a chloroacetamide group on the benzyl ring. This compound functions by inhibiting immunomodulatory effects and has shown promise in the treatment of various cancers and hematological disorders. It is particularly valuable for research into the modulation of immune responses and the exploration of novel therapeutic strategies.

In stock View Details

100 mg

$25.00

250 mg

$45.00

All 4 sizes
Cat. No.

A80815

CAS No.

2925099-90-5

CRBN ligand-624

CRBN ligand-624 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of the cereblon protein. This molecule can be conjugated to a target protein ligand through a linker, thereby enabling the formation of a PROTAC (proteolysis-targeting chimera). Its utility in targeted protein degradation makes it a valuable tool in research applications aimed at modulating protein levels within cellular systems.

View Details

Out of stock
All 3 sizes
Cat. No.

A80816

CAS No.

2925075-75-6

CRBN ligand-321

CRBN ligand-321 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. It can be conjugated to a target protein ligand through a linker to generate a proteolysis-targeting chimera (PROTAC). This compound is valuable for investigating ubiquitin-proteasome system modulation and identifying novel therapeutic strategies in target protein degradation research.

View Details

Out of stock
All 3 sizes
Cat. No.

A80817

CAS No.

2925103-45-1

CRBN ligand-706

CRBN ligand-706 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of CRBN to target proteins, enabling the development of proteolysis-targeting chimeras (PROTACs). CRBN ligand-706 serves as a valuable tool in research focused on targeted protein degradation and cellular regulation pathways.

View Details

Out of stock
All 3 sizes
Cat. No.

A80818

CAS No.

2925088-55-5

CRBN ligand-507

CRBN ligand-507 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of the cereblon protein, making it a valuable tool in targeted protein degradation research. CRBN ligand-507 can be conjugated to a target-specific ligand through a linker, enabling the creation of PROTACs for the selective degradation of intracellular proteins. Its applications include studying protein turnover and modulation of cellular pathways.

View Details

Out of stock
All 3 sizes
Cat. No.

A80819

CAS No.

2925072-28-0

CRBN ligand-607

CRBN ligand-607 is an E3 ubiquitin ligase cereblon (CRBN) ligand that effectively recruits the CRBN protein. This compound can be utilized to link a target protein ligand through a linker, facilitating the development of PROTACs (proteolysis-targeting chimeras). Its applications in molecular biology research include targeted protein degradation and the modulation of protein function, providing valuable insights into cellular processes.

View Details

Out of stock
All 3 sizes
Cat. No.

A80820

CAS No.

2925097-84-1

CRBN ligand-255

CRBN ligand-255 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the targeted recruitment of CRBN to specific proteins. This compound enables the design of proteolysis-targeting chimeras (PROTACs) by linking it with target protein ligands through a suitable linker. CRBN ligand-255 is valuable for research into targeted protein degradation and the modulation of cellular pathways through ubiquitin-proteasome system engagement.

View Details

Out of stock
All 3 sizes
Cat. No.

A80821

CAS No.

2957210-11-4

CRBN ligand-194

CRBN ligand-194 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC (proteolysis-targeting chimera). Its use in research enables the selective degradation of target proteins, making it a valuable tool for studying protein dynamics and therapeutic interventions in various diseases.

View Details

Out of stock
All 3 sizes

Loading...