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E3 ligase ligands bind ubiquitin ligases such as cereblon and von Hippel-Lindau (VHL) in degrader design. In a degrader, they anchor the ligase end of the molecule. E3 ubiquitin ligases transfer ubiquitin to substrate proteins and mark them for degradation by the proteasome. Thalidomide and its analogs bind cereblon (CRBN), a substrate receptor of a cullin-based E3 ligase complex identified as their direct target in 2010. The category includes cereblon ligands such as thalidomide fluoride and TD-106, and VHL ligands such as VL285 and VH032-cyclopropane-F. These ligands are used to build proteolysis-targeting chimeras (PROTACs) and to study how ligases are recruited to new substrates.
CRBN ligand-311 is a ligand that specifically targets the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of the CRBN protein, enabling the construction of Proteolysis Targeting Chimeras (PROTACs) when linked to target protein ligands through a suitable linker. CRBN ligand-311 is instrumental in studies focused on protein degradation and targeted therapeutic strategies in cancer and other diseases.
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CRBN ligand-759 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the CRBN protein. It can be utilized in the development of proteolysis-targeting chimeras (PROTACs) by attaching it to a target protein ligand through a linker. This compound is valuable for research applications aimed at studying targeted protein degradation and elucidating cellular mechanisms involving CRBN.
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Desamino lenalidomide-6-I functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This reagent can be conjugated with a target protein ligand through a suitable linker to create a PROTAC (Proteolysis Targeting Chimeras), which can enhance targeted protein degradation. It is valuable in research applications focused on ubiquitin-mediated proteolysis and drug development.
CRBN ligand-613 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling the recruitment of the cereblon protein. This compound can be utilized in the design of proteolysis-targeting chimeras (PROTACs) by linking it to a target protein ligand through a suitable linker. It assists in the targeted degradation of proteins, facilitating valuable research in protein regulation and therapeutic development.
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CRBN ligand-499 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be utilized to conjugate with target protein ligands through a linker, enabling the formation of PROTACs (proteolysis-targeting chimeras). CRBN ligand-499 is valuable for studies in targeted protein degradation and therapeutic development in various diseases.
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CRBN ligand-664 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker, enabling the development of proteolysis-targeting chimeras (PROTACs). Its use in research applications provides a powerful tool for targeted protein degradation and modulation of cellular functions.
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Desamino lenalidomide-7-propyne is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated with a target protein ligand through a linker to create a proteolysis-targeting chimera (PROTAC). Its ability to selectively induce target protein degradation makes it valuable in studies of protein regulation and therapeutic development for various diseases.
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CRBN ligand-323 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be effectively utilized to tether a target protein ligand through a linker, enabling the construction of proteolysis-targeting chimeras (PROTACs). Its application in targeted protein degradation offers valuable insights for drug discovery and therapeutic interventions.
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CRBN ligand-462 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. By linking CRBN ligand-462 to a specific target protein ligand via a suitable linker, researchers can design and synthesize PROTACs (Proteolysis Targeting Chimeras), enabling targeted degradation of proteins of interest. This reagent is valuable in studies involving protein regulation, cellular signaling pathways, and potential therapeutic development in diseases associated with protein misfolding or dysregulation.
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CRBN ligand-756 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. It is designed for use in the development of PROTACs (Proteolysis Targeting Chimeras) by linking to a target protein ligand through a suitable linker. This compound is essential for studying targeted protein degradation mechanisms and advancing research in cellular protein regulation.
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Thalidomide-4,5-F is a fluorinated analogue of Thalidomide, primarily acting through the promotion of protein ubiquitinylation. This modification can enhance the degradation of target proteins, making it a valuable tool for research in cellular regulation and signaling pathways. The compound's unique fluorinated structure allows for further derivatization at the fluorine sites, expanding its potential applications in medicinal chemistry and pharmaceutical development.
CRBN ligand-769 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), crucial for facilitating targeted protein degradation. It effectively recruits the cereblon protein, allowing for the development of bifunctional molecules when conjugated with target protein ligands through a linker. This compound is valuable in research focused on proteolysis targeting chimeras (PROTACs) and elucidating protein homeostasis.
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CRBN ligand-254 is a ligand that targets the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated with a target protein ligand through a linker to create a PROTAC (Proteolysis Targeting Chimera), enabling targeted degradation of specific proteins. CRBN ligand-254 is valuable in research related to protein homeostasis and therapeutic interventions through targeted protein modulation.
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Thalidomide-C-amide-C5-amine functions as a ligand for E3 ligases, facilitating targeted protein degradation in cellular contexts. This compound is specifically utilized in the synthesis of PROTAC BET Degrader-10, enabling selective modulation of BET proteins. Its applications extend to studies in protein homeostasis, cancer research, and the development of novel therapeutic strategies.
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CRBN ligand-449 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be effectively connected to a target protein ligand through a linker to create a PROTAC (proteolysis targeting chimera). CRBN ligand-449 is valuable for research into targeted protein degradation and the development of innovative therapeutics.
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CRBN ligand-572 is an E3 ubiquitin ligase cereblon (CRBN) ligand that facilitates the recruitment of the cereblon protein. This compound can be utilized to construct proteolysis-targeting chimeras (PROTACs) by linking it to target protein ligands through a suitable linker. CRBN ligand-572 is essential in studying protein degradation pathways and offers potential applications in targeted protein modulation for therapeutic research.
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CRBN ligand-318 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of CRBN to specific target proteins. This compound serves as a pivotal component in the development of PROTACs (proteolysis-targeting chimeras), enabling targeted protein degradation in cellular systems. Its unique ability to engage with CRBN makes it a valuable tool for investigating ubiquitin-proteasome pathway mechanisms and exploring new therapeutic strategies.
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CRBN ligand-619 is a ligand targeting the E3 ubiquitin ligase cereblon (CRBN), facilitating its recruitment for protein degradation processes. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera) for effective modulation of protein levels. CRBN ligand-619 is valuable for research applications in protein homeostasis, targeted therapy development, and the investigation of ubiquitin-proteasome system dynamics.
CRBN ligand-751 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the cereblon protein. This compound can be utilized in the development of PROTACs (proteolysis-targeting chimeras) by linking it to a target protein ligand through a suitable linker. CRBN ligand-751 is valuable for research applications in targeted protein degradation and the exploration of ubiquitin-proteasome system mechanisms.
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CRBN ligand-421 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. It can be utilized to construct proteolysis-targeting chimeras (PROTACs) by linking it to a target protein ligand through an appropriate linker. This compound is valuable for studies involving targeted protein degradation and the modulation of protein levels within cellular systems.
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CRBN ligand-615 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), utilized to recruit the CRBN protein in targeted protein degradation applications. It can be integrated with a target protein ligand through a linker, facilitating the formation of a PROTAC (proteolysis-targeting chimera). This compound enables selective degradation of specific proteins, making it valuable for research in areas such as cancer biology and targeted therapeutics.
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E3 ligase Ligand 66 is an E3 ligase ligand designed to specifically recruit inhibitor of apoptosis (IAP) proteins. This compound facilitates targeted protein degradation through the formation of PROTACs when conjugated with ligands such as SARS-CoV-2 Mpro ligand 1, enabling researchers to manipulate protein levels in cellular systems. Its applications extend to investigations in degradation pathways and therapeutic strategies against diseases, including viral infections.
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CRBN ligand-638 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of CRBN to target proteins, enabling targeted protein degradation through the formation of PROTACs (proteolysis-targeting chimeras). This compound is essential for studies focused on selective protein modulation and degradation pathways, contributing to advancements in therapeutic research and development.
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CRBN ligand-422 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be effectively conjugated to target protein ligands through a linker to create PROTACs, enabling targeted protein degradation. CRBN ligand-422 is valuable in research applications focused on proteolysis-targeting chimeras and the modulation of specific protein levels within cellular pathways.
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CRBN ligand-454 is an E3 ubiquitin ligase cereblon (CRBN) ligand that facilitates the recruitment of the cereblon protein. Its unique structure allows for conjugation with a target protein ligand through a linker, enabling the formation of a PROTAC. This compound is vital for studies focused on targeted protein degradation and can significantly contribute to the development of novel therapeutic strategies in cancer and other diseases linked to protein homeostasis.
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