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E3 Ligase Ligands

E3 ligase ligands bind ubiquitin ligases such as cereblon and von Hippel-Lindau (VHL) in degrader design. In a degrader, they anchor the ligase end of the molecule. E3 ubiquitin ligases transfer ubiquitin to substrate proteins and mark them for degradation by the proteasome. Thalidomide and its analogs bind cereblon (CRBN), a substrate receptor of a cullin-based E3 ligase complex identified as their direct target in 2010. The category includes cereblon ligands such as thalidomide fluoride and TD-106, and VHL ligands such as VL285 and VH032-cyclopropane-F. These ligands are used to build proteolysis-targeting chimeras (PROTACs) and to study how ligases are recruited to new substrates.

Cat. No.

A80760

CAS No.

3036607-19-6

CRBN ligand-148

CRBN ligand-148 is an E3 ubiquitin ligase ligand specifically targeting cereblon (CRBN). This compound facilitates the development of proteolysis-targeting chimeras (PROTACs) by promoting the ubiquitination and subsequent degradation of target proteins. Its biological activity is leveraged in research focused on targeted protein degradation and the modulation of cellular pathways.

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100 mg

$555.00

250 mg

$920.00

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Cat. No.

A80761

CAS No.

2925072-63-3

CRBN ligand-606

CRBN ligand-606 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of the CRBN protein, enabling targeted protein degradation through the formation of PROTACs when linked to specific target protein ligands. It is particularly useful in the study of protein homeostasis and degradation pathways, making it valuable for various research applications in cellular biology and therapeutic development.

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Cat. No.

A80762

CAS No.

2925082-11-5

CRBN ligand-298

CRBN ligand-298 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling the selective recruitment of CRBN to target proteins. By facilitating the formation of a PROTAC (proteolysis-targeting chimera), CRBN ligand-298 functions to promote targeted protein degradation, making it a valuable tool for studies in protein regulation and therapeutic development. This reagent is essential for researchers investigating the therapeutic potential of targeted protein degradation pathways.

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Cat. No.

A80763

CAS No.

2925082-42-2

CRBN ligand-371

CRBN ligand-371 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a proteolysis-targeting chimera (PROTAC). CRBN ligand-371 is useful in studies involving targeted protein degradation and the modulation of cellular pathways.

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Cat. No.

A80764

CAS No.

2925090-20-4

CRBN ligand-570

CRBN ligand-570 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the cereblon protein to target proteins. This compound can be utilized in the design of Proteolysis Targeting Chimeras (PROTACs) by linking it to specific target protein ligands through an appropriate linker. It is a valuable tool for studying targeted protein degradation and the therapeutic potential of modulating protein levels within cellular systems.

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Cat. No.

A80765

CAS No.

3050687-74-3

CRBN ligand-14

CRBN ligand-14 is a ligand targeting the CRBN E3 ubiquitin ligase, facilitating the formation of PROTACs (PROteolysis TArgeting Chimeras). This compound plays a crucial role in targeted protein degradation, enabling the selective elimination of proteins of interest within cellular systems. It is particularly valuable in drug discovery and development, providing insights into protein regulation and therapeutic interventions in various diseases.

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Cat. No.

A80766

CAS No.

2925069-66-3

CRBN ligand-389

CRBN ligand-389 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized in the development of proteolysis-targeting chimeras (PROTACs) by linking to target protein ligands through a suitable linker. The application of CRBN ligand-389 in research may aid in the modulation of protein degradation pathways and the exploration of targeted therapeutic strategies.

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Cat. No.

A80767

CAS No.

2970213-45-5

CRBN ligand-735

CRBN ligand-735 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), functioning to recruit the CRBN protein. This compound can be conjugated with a target protein ligand through a linker, facilitating the formation of a PROTAC (proteolysis-targeting chimera). CRBN ligand-735 is essential for research in targeted protein degradation and the development of novel therapeutic strategies that exploit the ubiquitin-proteasome system.

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Cat. No.

A80768

CAS No.

2761478-98-0

(S,R,R)-VH032 hydrochloride

(S,R,R)-VH032 hydrochloride is a selective ligand for the von Hippel-Lindau (VHL) E3 ligase. This compound facilitates the targeted degradation of proteins by enabling the formation of proteolysis-targeting chimeras (PROTACs) when conjugated to specific target protein ligands through a linker. Its unique mechanism allows for the modulation of cellular protein levels, making it a valuable tool in biochemical research and drug discovery applications.

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Cat. No.

A80769

CAS No.

2925095-74-3

CRBN ligand-762

CRBN ligand-762 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this protein for ubiquitination processes. This compound can be conjugated with target protein ligands through a linker to create proteolysis-targeting chimeras (PROTACs). Its application in targeted protein degradation makes it a valuable tool for studying cellular mechanisms and therapeutic interventions.

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Cat. No.

A80770

CAS No.

2925093-90-7

CRBN ligand-350

CRBN ligand-350 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein to target proteins. This compound is engineered for use in the development of Proteolysis Targeting Chimeras (PROTACs), enabling targeted protein degradation and therapeutic applications in various disease models. Its utility in chemical biology supports research aimed at elucidating protein interactions and regulatory mechanisms.

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Cat. No.

A80771

CAS No.

2925070-12-6

CRBN ligand-545

CRBN ligand-545 is an E3 ubiquitin ligase cereblon (CRBN) ligand that effectively recruits the cereblon protein. This compound facilitates the development of proteolysis-targeting chimeras (PROTACs) by enabling linkages to target protein ligands via a suitable linker. Its application in targeted protein degradation research underscores its potential in therapeutic development for various diseases.

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Cat. No.

A80772

CAS No.

2925089-49-0

CRBN ligand-311

CRBN ligand-311 is a ligand that specifically targets the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of the CRBN protein, enabling the construction of Proteolysis Targeting Chimeras (PROTACs) when linked to target protein ligands through a suitable linker. CRBN ligand-311 is instrumental in studies focused on protein degradation and targeted therapeutic strategies in cancer and other diseases.

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Cat. No.

A80773

CAS No.

2925099-99-4

CRBN ligand-759

CRBN ligand-759 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the CRBN protein. It can be utilized in the development of proteolysis-targeting chimeras (PROTACs) by attaching it to a target protein ligand through a linker. This compound is valuable for research applications aimed at studying targeted protein degradation and elucidating cellular mechanisms involving CRBN.

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Cat. No.

A80774

CAS No.

2757572-60-2

Desamino lenalidomide-6-I

Desamino lenalidomide-6-I functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This reagent can be conjugated with a target protein ligand through a suitable linker to create a PROTAC (Proteolysis Targeting Chimeras), which can enhance targeted protein degradation. It is valuable in research applications focused on ubiquitin-mediated proteolysis and drug development.

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5 mg

$35.00

10 mg

$60.00

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Cat. No.

A80775

CAS No.

2902654-72-0

CRBN ligand-613

CRBN ligand-613 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling the recruitment of the cereblon protein. This compound can be utilized in the design of proteolysis-targeting chimeras (PROTACs) by linking it to a target protein ligand through a suitable linker. It assists in the targeted degradation of proteins, facilitating valuable research in protein regulation and therapeutic development.

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Cat. No.

A80776

CAS No.

2925092-53-9

CRBN ligand-499

CRBN ligand-499 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be utilized to conjugate with target protein ligands through a linker, enabling the formation of PROTACs (proteolysis-targeting chimeras). CRBN ligand-499 is valuable for studies in targeted protein degradation and therapeutic development in various diseases.

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Cat. No.

A80777

CAS No.

2925095-08-3

CRBN ligand-664

CRBN ligand-664 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker, enabling the development of proteolysis-targeting chimeras (PROTACs). Its use in research applications provides a powerful tool for targeted protein degradation and modulation of cellular functions.

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Cat. No.

A80778

CAS No.

2412439-23-5

Desamino lenalidomide-7-propyne

Desamino lenalidomide-7-propyne is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated with a target protein ligand through a linker to create a proteolysis-targeting chimera (PROTAC). Its ability to selectively induce target protein degradation makes it valuable in studies of protein regulation and therapeutic development for various diseases.

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Cat. No.

A80779

CAS No.

2925072-56-4

CRBN ligand-323

CRBN ligand-323 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be effectively utilized to tether a target protein ligand through a linker, enabling the construction of proteolysis-targeting chimeras (PROTACs). Its application in targeted protein degradation offers valuable insights for drug discovery and therapeutic interventions.

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Cat. No.

A80780

CAS No.

2925070-49-9

CRBN ligand-462

CRBN ligand-462 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. By linking CRBN ligand-462 to a specific target protein ligand via a suitable linker, researchers can design and synthesize PROTACs (Proteolysis Targeting Chimeras), enabling targeted degradation of proteins of interest. This reagent is valuable in studies involving protein regulation, cellular signaling pathways, and potential therapeutic development in diseases associated with protein misfolding or dysregulation.

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Cat. No.

A80781

CAS No.

2925100-10-1

CRBN ligand-756

CRBN ligand-756 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. It is designed for use in the development of PROTACs (Proteolysis Targeting Chimeras) by linking to a target protein ligand through a suitable linker. This compound is essential for studying targeted protein degradation mechanisms and advancing research in cellular protein regulation.

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Cat. No.

A80783

CAS No.

2925072-78-0

CRBN ligand-769

CRBN ligand-769 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), crucial for facilitating targeted protein degradation. It effectively recruits the cereblon protein, allowing for the development of bifunctional molecules when conjugated with target protein ligands through a linker. This compound is valuable in research focused on proteolysis targeting chimeras (PROTACs) and elucidating protein homeostasis.

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Cat. No.

A80784

CAS No.

2925098-10-6

CRBN ligand-254

CRBN ligand-254 is a ligand that targets the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated with a target protein ligand through a linker to create a PROTAC (Proteolysis Targeting Chimera), enabling targeted degradation of specific proteins. CRBN ligand-254 is valuable in research related to protein homeostasis and therapeutic interventions through targeted protein modulation.

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Cat. No.

A80785

CAS No.

1957236-06-4

Thalidomide-C-amide-C5-amine

Thalidomide-C-amide-C5-amine functions as a ligand for E3 ligases, facilitating targeted protein degradation in cellular contexts. This compound is specifically utilized in the synthesis of PROTAC BET Degrader-10, enabling selective modulation of BET proteins. Its applications extend to studies in protein homeostasis, cancer research, and the development of novel therapeutic strategies.

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