Search by product name, CAS, target or catalog number. Press Down Arrow to reach product suggestions, Tab to move between links, and Escape to close suggestions.
E3 ligase ligands bind ubiquitin ligases such as cereblon and von Hippel-Lindau (VHL) in degrader design. In a degrader, they anchor the ligase end of the molecule. E3 ubiquitin ligases transfer ubiquitin to substrate proteins and mark them for degradation by the proteasome. Thalidomide and its analogs bind cereblon (CRBN), a substrate receptor of a cullin-based E3 ligase complex identified as their direct target in 2010. The category includes cereblon ligands such as thalidomide fluoride and TD-106, and VHL ligands such as VL285 and VH032-cyclopropane-F. These ligands are used to build proteolysis-targeting chimeras (PROTACs) and to study how ligases are recruited to new substrates.
CRBN ligand-730 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is designed to be linked with a target protein ligand via a linker to generate a PROTAC (PROteolysis TArgeting Chimeras), which enhances targeted protein degradation. It serves as a valuable tool for research in protein interaction and degradation mechanisms.
Out of stock
All 3 sizes
CRBN Ligand-744 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the development of PROTACs (proteolysis-targeting chimeras) for targeted protein degradation studies. Its primary applications include investigating cellular processes mediated by ubiquitination and developing therapeutic strategies for diseases related to protein misfolding and aggregation.
Out of stock
All 3 sizes
CRBN ligand-512 is a ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of the CRBN protein, enabling the formation of proteolysis-targeting chimeras (PROTACs) when linked to a target protein ligand through a suitable linker. It plays a crucial role in targeted protein degradation research applications, contributing to advancements in cellular signaling studies and therapeutic development.
Out of stock
All 3 sizes
CRBN ligand-519 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It is designed to facilitate the recruitment of cereblon, allowing for targeted protein degradation through the formation of PROTAC (Proteolysis Targeting Chimeras) when linked to a target protein ligand via a suitable linker. This compound serves as a valuable tool for elucidating cellular mechanisms and developing innovative therapeutic strategies by modulating protein levels in various biological contexts.
Out of stock
All 3 sizes
CRBN ligand-474 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated with a target protein ligand through a linker to create a proteolysis-targeting chimera (PROTAC). CRBN ligand-474 is valuable in studies of targeted protein degradation and ubiquitin-proteasome pathway modulation, providing insights into cellular regulation and therapeutic applications in various diseases.
Out of stock
All 3 sizes
CRBN ligand-600 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound plays a crucial role in the development of PROTACs (proteolysis-targeting chimeras), enabling targeted degradation of specific proteins through ubiquitin-proteasome pathways. It is valuable for researchers investigating protein regulation and potential therapeutic interventions in various diseases.
Out of stock
All 3 sizes
CRBN ligand-538 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of PROTACs for targeted protein degradation studies. CRBN ligand-538 is valuable in the investigation of protein regulation and therapeutic interventions in various biological contexts.
Out of stock
All 3 sizes
CRBN ligand-590 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the targeted recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a proteolysis-targeting chimera (PROTAC). CRBN ligand-590 is valuable for research applications focused on targeted protein degradation and the modulation of cellular protein levels.
Out of stock
All 3 sizes
CRBN ligand-592 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to target protein ligands through a linker, enabling the formation of Proteolysis Targeting Chimeras (PROTACs). CRBN ligand-592 serves as a valuable tool in targeted protein degradation research, allowing for the modulation of protein levels within cellular systems.
Out of stock
All 3 sizes
CRBN ligand-377 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of the CRBN protein, enabling targeted protein degradation when conjugated with a target protein ligand through a linker. This compound is valuable for research applications involving PROTAC (Proteolysis Targeting Chimeras) development, which are instrumental in the study of protein regulation and modulation in various biological contexts.
Out of stock
All 3 sizes
CRBN ligand-428 is a high-affinity ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of CRBN to target proteins, enabling the formation of PROTACs (Proteolysis Targeting Chimeras) for targeted protein degradation. This compound serves as a valuable tool for researchers investigating protein regulation and degradation pathways. Its applications include exploring therapeutic strategies in cancer and other diseases through targeted modulation of protein levels.
Out of stock
All 3 sizes
CRBN ligand-498 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this protein for targeted protein degradation. Its unique structure allows for the formation of PROTACs when conjugated with a target protein ligand through a linker. This compound is instrumental in advancing research on targeted therapies and protein modulation in various biological studies, providing a powerful tool for investigating the dynamics of protein interactions and degradation pathways.
Out of stock
All 3 sizes
CRBN ligand-477 is a ligand for cereblon (CRBN), an E3 ubiquitin ligase that plays a critical role in protein degradation pathways. This compound facilitates the recruitment of the CRBN protein, enabling the targeted degradation of specific proteins when linked to a target protein ligand via a suitable linker. CRBN ligand-477 is valuable in research applications involving targeted protein degradation and PROTAC development.
Out of stock
All 3 sizes
CRBN ligand-267 is an effective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated with a target protein ligand through a linker, enabling the formation of a proteolysis-targeting chimera (PROTAC). CRBN ligand-267 is valuable in research applications aimed at understanding protein degradation pathways and developing targeted therapies through the modulation of the ubiquitin-proteasome system.
Out of stock
All 3 sizes
CRBN ligand-423 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that plays a critical role in targeted protein degradation. This compound facilitates the recruitment of CRBN to specific target proteins and can be combined with target protein ligands through a linker to create a PROTAC (proteolysis-targeting chimera). Its application in the development of PROTACs provides valuable insights into the modulation of protein levels for therapeutic purposes in various biological research areas.
Out of stock
All 3 sizes
CRBN ligand-256 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this essential protein. This compound can be utilized in the development of PROTACs by linking it to a target protein ligand through a suitable linker. CRBN ligand-256 is instrumental in studies focused on targeted protein degradation and the modulation of various biological pathways.
Out of stock
All 3 sizes
CRBN ligand-728 is a ligand that targets the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN proteins. This compound is pivotal in the development of proteolysis-targeting chimeras (PROTACs) by enabling the linkage of target protein ligands through a suitable linker. Its use in research focuses on exploring targeted protein degradation pathways, advancing the understanding of cellular regulation, and uncovering therapeutic strategies in various diseases.
Out of stock
All 3 sizes
CRBN ligand-544 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized in the development of proteolysis-targeting chimeras (PROTACs) by linking it to a target protein ligand through a suitable linker. Its application in targeted protein degradation studies makes it a valuable tool for researchers investigating ubiquitin-proteasome pathway dynamics and therapeutic interventions in various diseases.
Out of stock
All 3 sizes
CRBN ligand-579 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to specific protein targets. This compound can be utilized to create proteolysis-targeting chimeras (PROTACs) by linking it to a target protein ligand through a suitable linker. Its capacity to modulate protein degradation pathways makes CRBN ligand-579 valuable for studies involving targeted protein degradation and cellular signaling research.
Out of stock
All 3 sizes
CRBN ligand-554 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling the targeted recruitment of the cereblon protein. This compound can be conjugated to a ligand of a target protein through a suitable linker to create a PROTAC (proteolysis-targeting chimera). It is applicable in studies focused on targeted protein degradation and the modulation of cellular pathways associated with ubiquitination.
Out of stock
All 3 sizes
CRBN ligand-325 is a ligand specific for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of the CRBN protein, enabling targeted protein degradation through the formation of PROTACs when linked to a target protein ligand via a suitable linker. It is valuable for applications in ubiquitination research and drug discovery strategies aimed at modulating protein levels within cells.
Out of stock
All 3 sizes
CRBN ligand-186 is a potent ligand for the CRBN-type E3 ubiquitin ligase, facilitating the construction of PROTAC (proteolysis targeting chimeras). This compound is designed to promote targeted protein degradation by harnessing the ubiquitin-proteasome system. It is instrumental in research applications aimed at investigating protein interactions and elucidating cellular processes involved in metabolic regulation and disease pathogenesis.
Out of stock
All 3 sizes
CRBN ligand-556 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein for targeted protein degradation. This compound can be utilized in the construction of PROTACs (Proteolysis Targeting Chimeras) by linking to target protein ligands, enabling precise modulation of protein levels. Its application is essential in studying protein homeostasis, cellular signaling pathways, and therapeutic interventions in various diseases.
Out of stock
All 3 sizes
CRBN ligand-680 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to specific target proteins. This compound can be utilized in the development of PROTACs (Proteolysis Targeting Chimeras) by linking to target protein ligands through a suitable linker. Its application is particularly relevant in the study of targeted protein degradation and the modulation of cellular pathways.
Out of stock
All 3 sizes
CRBN ligand-690 serves as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. Through the conjugation of CRBN ligand-690 with a target protein ligand via a linker, it enables the formation of PROTACs (proteolysis-targeting chimeras). This reagent is instrumental in studies aimed at targeted protein degradation and the modulation of protein abundance in various biological systems.
Out of stock
All 3 sizes