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E3 ligase ligands bind ubiquitin ligases such as cereblon and von Hippel-Lindau (VHL) in degrader design. In a degrader, they anchor the ligase end of the molecule. E3 ubiquitin ligases transfer ubiquitin to substrate proteins and mark them for degradation by the proteasome. Thalidomide and its analogs bind cereblon (CRBN), a substrate receptor of a cullin-based E3 ligase complex identified as their direct target in 2010. The category includes cereblon ligands such as thalidomide fluoride and TD-106, and VHL ligands such as VL285 and VH032-cyclopropane-F. These ligands are used to build proteolysis-targeting chimeras (PROTACs) and to study how ligases are recruited to new substrates.
CRBN ligand-273 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is designed for use in the development of PROTACs by linking specifically to target protein ligands via a linker, enabling targeted degradation of proteins in cellular contexts. Its applications extend to studies in protein homeostasis and targeted protein degradation mechanisms.
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CRBN ligand-289 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. It serves as a critical component in the development of PROTACs (proteolysis-targeting chimeras) by enabling the targeted degradation of specific proteins through the ubiquitin-proteasome pathway. This reagent is essential for exploring cellular mechanisms and therapeutic applications involving targeted protein degradation.
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CRBN ligand-500 is a ligand that targets the E3 ubiquitin ligase cereblon (CRBN) to facilitate the recruitment of this protein. It can be conjugated with a target protein ligand using a linker to create a proteolysis-targeting chimera (PROTAC). This compound is instrumental in studies aimed at protein degradation pathways and the modulation of cellular protein levels for therapeutic applications.
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CRBN ligand-453 is an E3 ubiquitin ligase ligand that specifically targets cereblon (CRBN) to facilitate its recruitment. This compound is designed to be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimera). It provides a powerful tool for targeted protein degradation studies and is applicable in research aimed at modulating protein levels in various biological contexts.
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CRBN ligand-369 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of proteolysis-targeting chimeras (PROTACs). CRBN ligand-369 is instrumental in studies focused on targeted protein degradation and therapeutic applications in various diseases.
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CRBN Ligand-382 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized in the development of proteolysis-targeting chimeras (PROTACs) by linking it to a target protein ligand through a suitable linker. Its application in targeted protein degradation research enables the exploration of innovative therapeutic strategies for various diseases.
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CRBN ligand-208 is a small-molecule ligand targeting the E3 ubiquitin ligase cereblon (CRBN). It is designed to facilitate the recruitment of CRBN to target proteins, enabling targeted protein degradation through PROTAC technology. This compound is applicable in research focusing on protein regulation and cellular signaling pathways, providing a valuable tool for drug discovery and development.
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CRBN ligand-753 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. By attaching this compound to a target protein ligand through a linker, it can be utilized in the development of PROTACs (proteolysis-targeting chimeras). This compound is particularly valuable in research focused on targeted protein degradation and investigating the function of specific proteins involved in various biological processes.
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CRBN ligand-686 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is designed to be conjugated with a target protein ligand through a linker, enabling the formation of a proteolysis-targeting chimera (PROTAC). It has potential applications in targeted protein degradation studies and investigating protein homeostasis in various biological contexts.
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CRBN ligand-478 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC (Proteolysis Targeting Chimeras). Its utility in controlling protein degradation makes it a valuable reagent for research applications in targeted protein modulation and therapeutic development.
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CRBN ligand-228 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein for targeted protein degradation. It can be conjugated with a target protein ligand through a linker to generate a PROTAC (proteolysis-targeting chimera). This compound is instrumental in studies aimed at exploring the degradation of specific proteins and developing novel therapeutic strategies in cancer and other diseases.
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CRBN ligand-620 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC, which enhances targeted protein degradation. CRBN ligand-620 is relevant for research applications in protein modulation and therapeutic development, particularly in the study of protein homeostasis.
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CRBN ligand-304 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated with a target protein ligand through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimera). CRBN ligand-304 is instrumental in studying protein degradation pathways and the development of targeted therapeutics in cancer research and other therapeutic areas.
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CRBN ligand-376 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized in the development of PROTACs by linking it to a target protein ligand through a suitable linker. Its application in targeted protein degradation provides valuable tools for elucidating protein functions and advancing therapeutic strategies.
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CRBN ligand-552 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of the CRBN protein, enabling the targeted degradation of specific proteins in cellular systems. This compound can be utilized in the design of PROTACs (proteolysis-targeting chimeras) by linking it to a target protein ligand through a suitable linker, making it a valuable tool in drug discovery and development.
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CRBN ligand-511 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the targeted recruitment of CRBN. This compound can be conjugated to target protein ligands through a linker to create proteolysis-targeting chimeras (PROTACs). Its application in degrading specific proteins makes it a valuable tool in chemical biology and therapeutic development for modulating cellular pathways.
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CRBN ligand-359 is a specialized ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling the recruitment of the cereblon protein for targeted degradation. This compound can be conjugated to a target protein ligand through a linker to construct a PROTAC, facilitating the selective modulation of protein levels in cellular studies. Its application in protein degradation research makes it a valuable tool for investigating protein function and developing novel therapeutic strategies.
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CRBN ligand-111 acts as a ligand for the CRBN E3 ubiquitin ligase, facilitating targeted protein degradation through PROTAC (proteolysis-targeting chimeras) technology. This compound is vital for research focused on the modulation of ubiquitin-proteasome pathways, enabling the selective degradation of proteins involved in various cellular processes. Its application is particularly significant in studies aimed at therapeutic development, including cancer biology and neurodegenerative diseases.
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VHL Ligand 35 is a selective ligand of the von Hippel-Lindau protein (pVHL) E3 ubiquitin ligase with a dissociation constant (Kd) of 0.291 μM. This compound effectively disrupts the protein-protein interaction between pVHL and hypoxia inducible factor 1α (HIF-1α), which is critical for regulating cellular responses to hypoxia. VHL Ligand 35 is valuable for research applications involving hypoxia signaling pathways and cancer biology, particularly in studies targeting the mechanisms of HIF regulation.
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CRBN ligand-366 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated with a target protein ligand through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimera). Its utility in protein degradation strategies makes it valuable for research in protein homeostasis and targeted therapeutics.
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CRBN Ligand-723 is an efficient ligand targeting the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of the cereblon protein and is designed to be conjugated to a target protein ligand through a linker to create a PROTAC (proteolysis-targeting chimera). It is valuable for research applications involving targeted protein degradation and cellular signaling pathways.
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CRBN ligand-458 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound is designed for use in the development of Proteolysis Targeting Chimeras (PROTACs) by linking to target protein ligands through a suitable linker. Its application enables targeted degradation of specific proteins, providing valuable tools for research in cancer biology and drug discovery.
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CRBN ligand-522 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), serving as a tool for targeted protein degradation. It facilitates the recruitment of cereblon to specific target proteins through a linking mechanism, enabling the formation of PROTACs (proteolysis-targeting chimeras). This compound is valuable for research applications aimed at elucidating the role of targeted degradation in cellular processes and for drug discovery strategies focusing on protein modulation.
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Desamino lenalidomide-6-C-COOH is a ligand for E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein in biochemical assays. This compound can be conjugated with a target protein ligand through a linker to create a proteolysis-targeting chimera (PROTAC), enabling targeted protein degradation. Its applications in drug development and cellular studies enhance understanding of protein regulation and therapeutic strategies.
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CRBN ligand-76 is a ligand for the CRBN E3 ubiquitin ligase, facilitating the development of PROTAC (Proteolysis Targeting Chimeras). This compound engages specifically with the CRBN E3 ligase, promoting ubiquitination and degradation of target proteins. Its application in targeted protein degradation offers potential for therapeutic intervention in various diseases, including cancer and neurodegenerative disorders.
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