Catalog No.
Product Name
Application
Product Information
Citations
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Ligand for E3 Ligase
CRBN ligand-536 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized in the design of PROTACs by linking it to a specific target protein ligand through a suitable linker, enabling targeted protein degradation. CRBN ligand-536 is instrumental for research applications in the fields of targeted therapy and proteomics. -
Ligand for E3 Ligase
CRBN ligand-701 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to target protein ligands through a linker to create PROTAC molecules, enabling targeted protein degradation. Its applications extend to research in targeted therapy and the study of protein regulation within cellular systems. -
Ligand for E3 Ligase
CRBN ligand-424 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is designed for use in PROTAC (Proteolysis Targeting Chimeras) development by linking to target protein ligands through a suitable linker. Its capacity to modulate protein degradation pathways makes it valuable for research in targeted protein degradation and therapeutic development. -
Ligand for E3 Ligase
CRBN ligand-683 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is particularly valuable for the development of PROTAC (Proteolysis Targeting Chimeras) by linking to target protein ligands through a suitable linker. CRBN ligand-683 is instrumental in studies of targeted protein degradation and may be harnessed in various research applications related to proteostasis and disease modulation. -
Ligand for E3 Ligase
CRBN ligand-510 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC. It plays a significant role in targeted protein degradation research, providing valuable insights for drug development and therapeutic interventions. -
Ligand for E3 Ligase
CRBN ligand-696 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It is designed to facilitate the recruitment of cereblon to specific target proteins. By linking CRBN ligand-696 to a target protein ligand through a suitable linker, it enables the formation of proteolysis-targeting chimeras (PROTACs), which are valuable tools for targeted protein degradation studies and therapeutic applications in cancer and other diseases. -
Ligand for E3 Ligase
CRBN ligand-308 is an E3 ubiquitin ligase cereblon (CRBN) ligand that facilitates the recruitment of the cereblon protein. This compound can be utilized to chemically link to a target protein ligand through a suitable linker, enabling the development of proteolysis-targeting chimeras (PROTACs). Its ability to modulate protein degradation pathways makes it a valuable tool for studying protein turnover and the therapeutic potential of targeted protein degradation in various biological contexts. -
Ligand for E3 Ligase
Thalidomide-SH is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of cereblon to target proteins, enabling targeted protein degradation through PROTAC technology. Thalidomide-SH serves as a versatile tool in chemical biology and drug discovery, offering potential applications in studying protein regulation and developing new therapeutic strategies. -
Ligand for E3 Ligase
CRBN ligand-412 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of CRBN to target proteins, enabling the formation of proteolysis-targeting chimeras (PROTACs). This compound is essential for studies focused on targeted protein degradation and therapeutic applications in cancer research and other diseases. -
Ligand for E3 Ligase
CRBN ligand-578 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. It can be conjugated to target protein ligands through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimera). This compound is valuable for studies in targeted protein degradation and cellular protein modulation, making it useful in therapeutic research and drug development. -
Ligand for E3 Ligase
CRBN ligand-455 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the cereblon protein. This compound can be utilized to create proteolysis-targeting chimeras (PROTACs) by linking to a target protein ligand through a suitable linker, enabling targeted protein degradation. It serves as a valuable tool for exploring protein function and regulation, particularly in the context of drug discovery and therapeutic development. -
Ligand for E3 Ligase
CRBN ligand-392 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of CRBN to specific target proteins. This compound is utilized in the development of proteolysis-targeting chimeras (PROTACs) when covalently linked to a target protein ligand through a suitable linker, enabling selective degradation of the target protein. Research applications include targeted protein degradation studies and exploring novel therapeutic approaches in cellular biology. -
Ligand for E3 Ligase
CRBN ligand-391 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of proteolysis-targeting chimeras (PROTACs). It plays a significant role in targeted protein degradation research and drug discovery applications, contributing to advancements in therapeutic strategies for various diseases. -
Ligand for E3 Ligase
CRBN ligand-626 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This molecule can be conjugated to a target protein ligand through a linker, enabling the formation of a proteolysis-targeting chimera (PROTAC). Researchers can utilize CRBN ligand-626 in studies exploring targeted protein degradation and the modulation of various biological pathways. -
E3 Ligase Activator
Thalidomide-4-Br,7-F is an E3 ligase activator, containing both bromine and fluorine substituents. E3 ligases play a crucial role in the ubiquitin-proteasome system by tagging proteins for degradation, thereby regulating various cellular processes. This compound's halogen functional groups allow for potential further derivatization, making it a valuable tool for research in protein degradation pathways and targeted protein modulation. Its application extends to studies involving cancer biology, protein regulation, and therapeutic development. -
Ligand for E3 Ligase
CRBN ligand-757 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a proteolysis-targeting chimeric molecule (PROTAC). CRBN ligand-757 serves as a valuable tool in chemical biology and therapeutic development, particularly in studies focused on targeted protein degradation. -
Ligand for E3 Ligase
CRBN ligand-535 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is suitable for use in the development of PROTACs, enabling targeted protein degradation through an innovative bifunctional mechanism. Its ability to bridge ligands to target proteins makes it valuable for researchers studying ubiquitin-proteasome system modulation and therapeutic protein degradation strategies. -
Ligand for E3 Ligase
Desamino lenalidomide-4-F-7-Br is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of CRBN, enabling targeted protein degradation through the formation of PROTACs when linked with a target protein ligand. Its application in research includes investigating the role of CRBN in various cellular processes and potential therapeutic strategies in cancer and other diseases. -
Ligand for E3 Ligase
CRBN ligand-443 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be utilized in the development of PROTAC (Proteolysis Targeting Chimeras) by linking it to a target protein ligand through a suitable linker. Its application in targeted protein degradation supports innovative research in therapeutic development and cellular regulation. -
Ligand for E3 Ligase
Thalidomide-Piperazine-PEG2-NH2 hydrochloride is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be utilized in the development of PROTACs by linking it to a target protein ligand via a suitable linker, thus advancing research in targeted protein degradation and related therapeutic applications. Its ability to modulate protein levels makes it a valuable tool in cellular and molecular biology studies. -
Ligand for E3 Ligase
CRBN ligand-484 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to target protein ligands through a linker, enabling the development of PROTACs that promote targeted protein degradation. Its utility in research includes exploring the mechanisms of ubiquitin-proteasome system modulation and protein homeostasis in cellular contexts. -
Ligands for E3 Ligase
(S,S,S)-AHPC is a specific ligand for E3 ligases, serving as a crucial component in targeted protein degradation applications. It is utilized for the synthesis of PROTAC AH081, which can facilitate the degradation of specific proteins within cells. This compound is an important tool in research focused on understanding protein interactions and developing novel therapeutic strategies through modulation of E3 ligase activity. -
Ligand for E3 Ligase
CRBN ligand-488 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN for targeted protein degradation. This compound can be conjugated with a target protein ligand through a linker to create a proteolysis-targeting chimera (PROTAC). Its utility in targeted protein elimination makes it an important tool for investigating cellular processes and therapeutic applications in cancer and other diseases. -
Ligand for E3 Ligase
CRBN ligand-741 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of cereblon, enabling the formation of proteolysis-targeting chimeras (PROTACs) when linked to a target protein ligand via a suitable linker. This compound is valuable for studies in targeted protein degradation, offering potential applications in drug development and cancer research. -
Ligand for E3 Ligase
CRBN ligand-307 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of PROTACs (proteolysis-targeting chimeras). CRBN ligand-307 is valuable in research applications focused on targeted protein degradation and the modulation of cellular protein levels, making it an essential tool for studies in drug discovery and therapeutic development. -
Ligands for E3 Ligase
CRBN ligand-45 functions as a ligand for the CRBN-type E3 ubiquitin ligase, facilitating targeted protein degradation through the proteolysis-targeting chimera (PROTAC) technology. This compound is essential for research applications focused on investigating ubiquitination pathways and developing novel therapeutic strategies that harness the ubiquitin-proteasome system. Its ability to selectively engage E3 ligases makes it a valuable tool in the study of cellular protein homeostasis and degradation mechanisms. -
Ligand for E3 Ligase
Thalidomide-5-methanol is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound has applications in the development of proteolysis-targeting chimeras (PROTACs) by enabling the linkage to target protein ligands via a suitable linker. Thalidomide-5-methanol is utilized in research exploring targeted protein degradation and the therapeutic potential of modulating CRBN activity. -
Ligand for E3 Ligase
CRBN ligand-796 serves as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound is designed for use in PROTAC (PROteolysis TArgeting Chimeras) technology, allowing for the targeted degradation of proteins by linking to specific target protein ligands through a suitable linker. Its role in modulating protein degradation pathways makes it a valuable tool for research in targeted therapeutics and cellular signaling studies. -
Ligand for E3 Ligase
CRBN ligand-589 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated with a target protein ligand through a linker to create a proteolysis-targeting chimeric molecule (PROTAC). Its applications in chemical biology include the modulation of protein degradation pathways and the investigation of targeted protein therapy mechanisms. -
Ligand for E3 Ligase
CRBN ligand-229 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be successfully linked to a target protein ligand through a linker to create a PROTAC (proteolysis-targeting chimera). Research applications of CRBN ligand-229 include targeted protein degradation and the study of ubiquitin-mediated proteostasis pathways. -
Ligand for E3 Ligase
CRBN ligand-858 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is instrumental in the development of proteolysis-targeting chimeras (PROTACs) when linked to a target protein ligand through an appropriate linker. Its applications extend to advancing research in targeted protein degradation and exploring novel therapeutic strategies. -
Ligand for E3 Ligase
CRBN ligand-644 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this protein to target substrates. It can be conjugated to target protein ligands through a linker to generate a PROTAC (proteolysis-targeting chimera), enabling targeted protein degradation. This reagent is valuable for research in protein dynamics and therapeutic development through modulation of the ubiquitin-proteasome system. -
Ligand for E3 Ligase
CRBN ligand-718 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein in cellular assays. This compound serves as a valuable tool for the development of proteolysis-targeting chimeras (PROTACs) by linking to a target protein ligand via a linker. Its applications include studying protein degradation pathways and creating innovative therapeutic strategies in targeted protein degradation research. -
Ligand for E3 Ligase
CRBN ligand-295 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of CRBN to target proteins, enabling targeted protein degradation through the formation of proteolysis-targeting chimeras (PROTACs). It is ideal for research applications in drug discovery and development, particularly in the study of protein homeostasis and cellular regulation. -
Ligand for E3 Ligase
CRBN ligand-290 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound serves as a building block for the development of PROTACs (Proteolysis Targeting Chimeras) by enabling the conjugation of CRBN with a target protein ligand through a suitable linker. Its application is significant in studies involving targeted protein degradation, offering insights into therapeutic interventions and functional protein regulation in various biological contexts. -
KLHDC2 Ligand
SJ6145 is a potent ligand for KLHDC2, exhibiting a dissociation constant (Kd) of 16.9 μM as determined by surface plasmon resonance (SPR) assays. This compound demonstrates an IC50 value of 42 μM in inhibiting KLHDC2's binding to a di-Gly degron peptide, highlighting its potential role in investigating KLHDC2-mediated cellular processes. SJ6145 can be utilized in research applications focused on protein degradation and regulatory mechanisms in cellular homeostasis. -
Ligand for E3 Ligase
CRBN ligand-629 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of cereblon to specific target proteins. This compound can be employed in the design of PROTACs (PROteolysis-TArgeting Chimeras) by linking it to a target protein ligand through a suitable linker. Its application in targeted protein degradation makes it a valuable tool for researchers investigating novel therapeutic approaches in cancer and other diseases. -
Ligand for E3 Ligase
CRBN ligand-637 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein in targeted protein degradation applications. This compound can be conjugated with a target protein ligand through a linker to create a PROTAC (proteolysis-targeting chimera), enabling the selective degradation of specific proteins. Its use in research may aid in elucidating mechanisms of protein regulation and disease pathways. -
Ligand for E3 Ligase
CRBN ligand-386 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand using a linker to create a proteolysis-targeting chimera (PROTAC). Its ability to adapt and selectively induce protein degradation makes it a valuable tool in chemical biology and therapeutic research, particularly in studying targeted protein degradation mechanisms. -
Ligand for E3 Ligase
CRBN ligand-689 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the engagement of CRBN with target proteins. This compound can be utilized in the development of PROTACs (proteolysis-targeting chimeras) by linking to a target protein ligand through a suitable linker. Its design is aimed at enhancing targeted protein degradation, making it a valuable tool for research in cellular signaling and therapeutic applications. -
Ligands for E3 Ligase
CRBN ligand-112 is a selective ligand for the CRBN-type E3 ubiquitin ligase, serving as a critical component in the development of proteolysis-targeting chimeras (PROTACs). This compound facilitates the ubiquitination and subsequent degradation of target proteins, offering a powerful tool for investigating cellular protein turnover and modulation. Its application in research spans various fields, including cancer therapy and targeted protein degradation studies. -
Ligand for E3 Ligase
CRBN ligand-482 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this protein in cellular processes. It serves as a crucial component for the development of PROTACs (proteolysis-targeting chimeras) by creating a linkage between a target protein ligand and cereblon. This compound is valuable for research applications focused on targeted protein degradation and the modulation of protein levels within cells. -
Ligands for E3 Ligase
CRBN ligand-74 is a potent ligand for the CRBN E3 ubiquitin ligase, facilitating the development of PROTAC (Proteolysis Targeting Chimeras). It serves as a valuable tool in targeted protein degradation research, enabling the selective degradation of intracellular proteins. This compound is instrumental in studying various biological processes and therapeutic applications related to protein homeostasis. -
Ligand for E3 Ligase
Desamino lenalidomide-4-Br-5-F is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be utilized to create PROTACs (proteolysis-targeting chimeras) by linking it to a target protein ligand through a suitable linker. Its ability to modulate protein degradation makes it valuable in various research applications, including targeted protein elimination and the study of cellular mechanisms involving ubiquitin-proteasome pathways. -
Ligand for E3 Ligase
CRBN ligand-568 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to specific target proteins. This compound can be equipped with a linker to create a PROTAC (proteolysis-targeting chimeras), enabling targeted protein degradation. CRBN ligand-568 is beneficial for studying protein regulation and ubiquitination processes in various biological contexts. -
Ligand for E3 Ligase
CRBN ligand-375 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated with target-specific ligands through a linker to construct proteolysis-targeting chimeras (PROTACs). It is useful in studies aimed at modulating protein degradation pathways and investigating the role of CRBN in cellular processes. -
Ligands for E3 Ligase
CRBN ligand-16 is a ligand for the E3 ubiquitin ligase CRBN, enabling targeted protein degradation through the formation of PROTAC molecules. This compound facilitates the ubiquitination and subsequent proteasomal degradation of specific proteins, offering valuable applications in drug development and disease research. Its utility in creating bifunctional degradation agents makes it a crucial tool for studies involving protein modulation and therapeutic interventions. -
Ligand for E3 Ligase
CRBN ligand-427 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein to target proteins. This compound can be conjugated to a target protein ligand via a linker, enabling the formation of a PROTAC, a powerful tool for targeted protein degradation studies. Its application in protein modulation makes it valuable for various research avenues in therapeutic discovery and cellular biology. -
Ligands for E3 Ligase
CRBN ligand-84 is a ligand for the CRBN-type E3 ubiquitin ligase, facilitating the ubiquitination process through targeted protein degradation. This compound is integral in the design and synthesis of PROTAC molecules, enabling the selective elimination of unwanted proteins in cellular studies. Its utility in research applications extends to investigating protein turnover and degradation pathways, supporting drug discovery efforts in targeted therapies. -
Ligand for E3 Ligase
CRBN ligand-574 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the targeted recruitment of the cereblon protein. This compound can be utilized to create PROTACs by linking it to a target protein ligand through a suitable linker. Researchers can employ CRBN ligand-574 in studies aimed at exploring targeted protein degradation pathways and therapeutic development in various disease models.
