Search by product name, CAS, target or catalog number. Press Down Arrow to reach product suggestions, Tab to move between links, and Escape to close suggestions.
Dopamine receptor agonists and antagonists act on the five G protein-coupled receptors that respond to dopamine. The receptors form two groups, with D1 and D5 in the D1-like class and D2, D3 and D4 in the D2-like class. D1-like receptors stimulate adenylyl cyclase, whereas D2-like receptors inhibit it and lower cyclic adenosine monophosphate (cAMP) levels. Dopamine signaling controls movement, reward, motivation and hormone release, and is studied in Parkinson's disease and psychiatric research. Ligands here include the agonist rotigotine HCl, the D2 antagonists L-741626 and domperidone, and the D3-preferring ligand BP897.
Isoremoxipride is a dopamine antagonist that selectively targets the dopamine D2 receptor. This 3-methoxy isomer demonstrates significant affinity for the receptor, making it a valuable tool for investigating dopamine-related pathways. Its research applications include studies on neuropsychiatric disorders and the role of dopamine in various neurological conditions.
Out of stock
All 3 sizes
D4R antagonist-1 is a selective antagonist of the dopamine D4 receptor (D4R) with an IC50 of 6.87 µM. This compound exhibits significant potential for use in research related to neurological disorders, including Parkinson's disease. Its ability to modulate D4R activity makes it a valuable tool for investigating the role of dopamine signaling in various physiological and pathological processes.
Out of stock
All 3 sizes
Dopamine D3 receptor ligand-6 is a selective antagonist of the dopamine D3 receptor. This compound is valuable for investigating mechanisms involved in substance use disorders, including opioid and psychostimulant addiction. Its specificity for the D3 receptor makes it an important tool in pharmacological studies aimed at understanding and potentially mitigating addiction-related behaviors.
Out of stock
All 3 sizes
S33084 is a selective antagonist of the dopamine D(3) receptor, exhibiting pKi values of 8.72, 8.62, and 6.82 for cloned rat dopamine D3, native rat dopamine D3, and D2 receptors, respectively. This pharmacological profile indicates its potency and specificity in targeting the D(3) receptor. S33084 is primarily utilized in research focusing on neuropharmacology, aiding investigations into the role of dopamine signaling in various neurological disorders.
Out of stock
All 3 sizes
ADR 851 is a potent antagonist of the dopamine D2 receptor, known for its role in neurotransmitter signaling. This compound demonstrates significant activity in modulating dopaminergic pathways and has been utilized in research related to antiemetic therapies. Its effectiveness in targeting the D2 receptor makes it a valuable tool for studies investigating the mechanisms of nausea and emesis.
Synonyms: PNU-96391
(-)-OSU6162 is a potent presynaptic dopamine receptor antagonist, primarily targeting the D2 dopamine receptor subtype. It exhibits inhibitory effects on dopamine release, making it valuable for research on dopaminergic signaling and its implications in neuropsychiatric disorders. This compound is useful for studying the role of dopamine in various biological systems and can aid in the development of treatments for conditions such as schizophrenia and addiction.
PD-89211 is a selective antagonist of the dopamine D4 receptor, exhibiting a Ki value of 3.7 nM. It effectively reverses Quinpirole-induced [3H]thymidine uptake in CHOpro5 cells, with an IC50 of 2.1 nM. This compound plays a significant role in regulating dopamine and norepinephrine metabolism in the hippocampus, making it valuable for research into central nervous system disorders, including schizophrenia.
Synonyms: rel-SCH 39166 hydrobromide
rel-Ecopipam hydrobromide is a potent D1 receptor antagonist with a Ki value of 1.30 nM. This compound effectively inhibits dopamine D1 receptor activity, making it a valuable tool for research in neuropharmacology and the study of dopamine signaling pathways. Its unique mechanism of action positions it for investigations into the role of D1 receptors in various neurobiological processes and potential therapeutic targets for neurological disorders.
BRD5814 is a potent antagonist of the dopamine D2 receptor (D2R), a key target in the modulation of dopaminergic signaling. This compound demonstrates significant inhibitory activity, making it a valuable tool in research focused on schizophrenia and other neuropsychiatric disorders. Its application in studies of D2R-related pathways can aid in understanding the complex mechanisms underlying these conditions.
Brl 20596 is a potent central dopamine receptor antagonist. This compound exhibits significant inhibitory activity at dopamine receptors, making it valuable for antipsychotic research. Its ability to modulate dopaminergic signaling can aid in the investigation of neuropsychiatric disorders related to dopamine dysregulation.
(Rac)-GR218231 is a selective antagonist of the dopamine D3 receptor, exhibiting a pKi value of 8.9. This compound is valuable for studying the role of D3 receptors in various neurological and psychiatric disorders. Its pharmacological properties make it an important tool for research into dopamine-related pathways and potential therapeutic interventions.
Out of stock
All 3 sizes
ADR 851 free base is a potent antagonist of the dopamine D2 receptor, making it valuable for research applications focused on antiemetic effects. This compound demonstrates significant potential in modulating dopamine-related pathways, contributing to the understanding of various neurological and psychiatric disorders. Its utilization in experimental studies may provide insights into therapeutic strategies targeting nausea and vomiting.
Synonyms: PNU-101387G mesylate; U-101387G mesylate
Sonepiprazole mesylate is a selective D4 dopamine receptor antagonist that exhibits inhibition constants (Kis) of 3.6 nM for rD4-Dopamine and 10.1 nM for hD4.2-Dopamine, indicating potent activity at these targets. Additionally, it shows significantly lower affinity for rD2-Dopamine (5147 nM) and Histamine-H1 receptors (7430 nM). This compound is valuable for research applications focused on neurobiology, particularly in studies related to dopamine receptor signaling and its implications in psychiatric disorders.
A31472 is a potent antagonist of dopamine D-2 receptors, making it a valuable tool for studying the pharmacology of antipsychotic agents. Its mechanism of action is critical for exploring the underlying pathways associated with dopamine dysregulation. Researchers can utilize A31472 to investigate its effects on behavioral and neurochemical processes relevant to psychiatric disorders.
Out of stock
All 3 sizes
Synonyms: Clotixamide
Clothixamide is a dopamine antagonist that primarily targets dopamine receptors in the central nervous system. It exhibits biological activity relevant to the modulation of dopaminergic signaling and is useful for investigating various psychiatric disorders, including schizophrenia and depression. Research applications include studying the effects of dopamine inhibition on behavior and neurotransmitter pathways.
Org-10490 is a potent antagonist of dopamine D1 and D2 receptors, primarily utilized in neurological and psychiatric research. It plays a critical role in studies related to disorders such as schizophrenia and bipolar disorder by modulating dopaminergic signaling pathways. Its efficacy in receptor inhibition makes Org-10490 valuable for investigating therapeutic strategies targeting dopamine-related conditions.
Lensiprazine is a potent dopamine D2 receptor antagonist that also functions as a serotonin reuptake inhibitor. This compound is primarily utilized in research focusing on psychiatric disorders, including bipolar disorder and schizophrenia, facilitating the exploration of neurochemical pathways involved in these conditions. Its dual action provides valuable insights into the modulation of neurotransmitter systems.
Savoxepin mesylate is a selective antagonist of the D2 dopamine receptor, exhibiting antipsychotic properties. It specifically targets dopamine D2 receptors in the hippocampus while sparing those in the striatum, thereby minimizing the likelihood of extrapyramidal side effects. This selective action makes Savoxepin mesylate a valuable tool for research addressing dopaminergic signaling and its implications in neuropsychiatric disorders.
Synonyms: (-)-Remoxipride hydrochloride hydrate
(S)-Remoxipride hydrochloride hydrate is a selective antagonist of the dopamine D2 receptor, exhibiting an IC50 value of 1.57 μM. This compound is primarily utilized in the study of psychotic disorders, providing a valuable tool for understanding the mechanisms underlying dopamine-related pathologies and developing therapeutic strategies. Its specificity for the D2 receptor makes it an important reagent in neuropharmacology research.
Milenperone is a potent dopamine antagonist that primarily targets dopamine receptors. Its biological activity allows for the modulation of dopaminergic signaling, making it valuable in research focusing on neurological disorders. Milenperone is particularly useful in studies investigating the mechanisms underlying conditions related to dopamine dysregulation.
Desethoxy Quetiapine dihydrochloride is a selective antagonist of the dopamine D2 receptor, exhibiting an IC50 value of 1330 nM. This compound effectively inhibits Apomorphine-induced climbing and swimming behavior in murine models, making it valuable for investigating neuropharmacological activity and the modulation of dopaminergic signaling. Its utility in behavioral studies supports research into the therapeutic effects of D2 receptor antagonism in psychiatric disorders.
SKF 83509 is a selective dopamine D1 antagonist with a Ki value of 70.2 nM, demonstrating no activity at dopamine D2 receptors. This compound is primarily utilized in neuropharmacological research to investigate the role of dopamine D1 receptors in various neurological conditions. SKF 83509 aids in the exploration of dopaminergic signaling pathways and contributes to studies focused on drug addiction, schizophrenia, and other dopamine-related disorders.
Synonyms: PNU-101387G hydrochloride; U-101387G hydrochloride
Sonepiprazole hydrochloride is a selective antagonist of the D4 dopamine receptor, exhibiting Ki values of 3.6 nM for the rat D4 dopamine receptor and 10.1 nM for the human D4.2 dopamine receptor. This compound demonstrates significant selectivity, with much higher Ki values of 5147 nM and 7430 nM for the rat D2 dopamine and Histamine H1 receptors, respectively. Sonepiprazole hydrochloride is useful for investigating the role of D4 receptors in neurological disorders and may have applications in psychopharmacology research.
Butaclamol is an antipsychotic agent that functions primarily as a D2 dopamine receptor antagonist. This compound exhibits significant neuroleptic activity, making it a valuable tool in the study of psychotic disorders. It is utilized in research to explore the mechanisms underlying dopaminergic signaling and its implications in various neuropsychiatric conditions.
Synonyms: R-1838
Deschlorohaloperidol is a potent analogue of Haloperidol, primarily acting as a dopamine D2 receptor (D2R) antagonist. This compound exhibits significant antipsychotic activity, making it valuable in research focused on schizophrenia and related disorders. Its structural modifications enhance its efficacy for investigating dopamine signaling pathways and therapeutic interventions in psychiatric conditions.
