Dopamine Receptors

Cat. No.

A60228

CAS No.

224170-09-6

U-101958 maleate

Synonyms: PNU-101958 maleate

U-101958 maleate is a highly selective antagonist for the dopamine D4 receptor, exhibiting an IC50 of 2.7 nM. In HEK-293 cells expressing the human recombinant D4.4 receptor, U-101958 behaves as an agonist, demonstrating its versatile interaction with this target. This compound is primarily utilized in research related to antipsychotic effects and the modulation of dopaminergic signaling pathways.

Cat. No.

A60231

CAS No.

108226-05-7

Benzamide Derivative 1

Benzamide Derivative 1 is a dopamine receptor antagonist with potential applications in the treatment of gastrointestinal disorders. This compound, derived from patent EP0213775A1, compound 18, exhibits key biological activity by modulating dopamine signaling pathways. Its role in gastrointestinal function makes it a valuable tool for researchers investigating the interplay between dopamine receptors and gut health.

Cat. No.

A66204

CAS No.

2517420-92-5

(Rac)-NNC 55-0396

(Rac)-NNC 55-0396 is a racemic mixture that targets the dopamine D2 receptor. This compound is of significant interest in neurological research due to its potential role in modulating dopaminergic signaling pathways. It is commonly utilized in studies investigating the pharmacological effects of dopamine receptor antagonists in various neurological disorders.

Cat. No.

A70887

CAS No.

34104-67-1

Reduced Haloperidol

Synonyms: Haloperidol metabolite II

Reduced Haloperidol, a primary metabolite of Haloperidol, functions as a dopamine receptor antagonist. It exhibits significant antipsychotic activity, primarily utilized in research related to schizophrenia and other psychotic disorders. This compound is instrumental in studies investigating the modulation of neurotransmitter systems, aiding in the reduction of hallucinations and delusions associated with these conditions.

Cat. No.

A97171

CAS No.

71676-01-2

Amisulpride N-oxide

Amisulpride N-oxide is a photodegradation product of Amisulpride, which acts as a dopamine D2/D3 receptor antagonist. This compound may be relevant for studies investigating the stability and degradation pathways of Amisulpride under light exposure. Its characterization can aid researchers in understanding the pharmacokinetics and metabolic processes associated with dopamine receptor modulation.

Cat. No.

B21536

CAS No.

69-23-8

Fluphenazine

Fluphenazine is a potent dopamine receptor antagonist primarily targeting postsynaptic dopamine D2 receptors in the mesolimbic, nigrostriatal, and tuberoinfundibular pathways. This phenothiazine derivative exhibits substantial biological activity by inhibiting dopamine signaling, making it useful for studying psychosis and diabetic peripheral neuropathy. Additionally, Fluphenazine has shown potential in inhibiting SARS-CoV-2, contributing to its relevance in current research focused on neuropharmacology and viral pathogenesis.

Cat. No.

B21616

CAS No.

58-40-2

Promazine

Synonyms: Romtiazin; Ampazine; Berophen

Promazine is a dopamine receptor D2 antagonist that primarily functions by inhibiting dopaminergic neurotransmission. This compound is utilized in research related to psychotic disorders and provides insights into dopamine-mediated pathways. Its application extends to studying the neuropharmacology of antipsychotic treatments and understanding the mechanisms underlying various psychiatric conditions.

Cat. No.

B21633

CAS No.

50-52-2

Thioridazine

Thioridazine is a dopamine receptor D2 antagonist known for its potent antipsychotic and anxiolytic properties. In addition to its neuropharmacological effects, Thioridazine significantly inhibits the PI3K-Akt-mTOR signaling pathway, exhibiting anti-angiogenic activity. It has demonstrated antiproliferative effects and the ability to induce apoptosis in various cancer cell types, with a particular efficacy in targeting cancer stem cells (CSCs). These characteristics make Thioridazine a valuable compound for research in neurobiology and cancer therapeutics.

Cat. No.

B21933

CAS No.

93801-18-4

N-(p-Aminophenethyl)spiperone

N-(p-Aminophenethyl)spiperone is a selective antagonist of D2-like dopamine receptors. This compound binds specifically to the ligand recognition sites of functional D2 and D3 receptors, making it a valuable tool for researchers studying dopamine signaling pathways. N-(p-Aminophenethyl)spiperone is primarily used for labeling, localizing, and identifying D2 and D3 dopamine receptors in various biological systems.