Catalog No.
Product Name
Application
Product Information
Citations
-
NF-κB Inhibitor, GPx Inhibitor, HIV Replication Inhibitor
α-MSH (11-13) acetate is a selective melanocortin-1 receptor ligand that functions as an inhibitor of NF-κB, GPx activity, and HIV replication. It induces an acute elevation of intracellular calcium levels under certain costimulation or pathway inhibition conditions. This compound effectively suppresses TNF-α-induced NF-κB activation, inhibits colony formation of Staphylococcus aureus and Candida albicans, and demonstrates potential in the study of infections related to these pathogens, as well as in traumatic brain injury, corneal epithelial wounds, and inflammatory bowel disease research. -
SLC7A11 Inhibitor, GPX4 Inhibitor
Anti-NSCLC agent-2 (compound 6o) functions as a dual inhibitor of SLC7A11 and GPX4, key regulators of ferroptosis. By disrupting redox homeostasis and depleting glutathione levels, this compound facilitates the accumulation of lipid peroxides, leading to the induction of ferroptosis in non-small cell lung cancer (NSCLC) cells. Anti-NSCLC agent-2 is a valuable tool for research focused on understanding and targeting non-small cell lung cancer mechanisms.
