Mps1

Cat. No.

A11170

CAS No.

1124329-14-1

AZ 3146

AZ 3146 is a potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 35 nM). It interferes with chromosome alignment and overrides spindle assembly checkpoint and also Inhibits the recruitment of Mad1, Mad2 and centromere protein E (CENP-E) to kinetochores.

Cat. No.

A11218

CAS No.

1125593-20-5

Mps1-IN-1

Mps1-IN-1 is a highly potent and selectibe Mpsl inhibitor with IC50 of 367 nM; >1000-fold selectivity relative to the 352 member kinase panel with the major exceptions of Alk and Ltk.

Cat. No.

A14290

CAS No.

1246529-32-7

MPI-0479605

MPI-0479605 is an ATP competitive and selective inhibitor of mitotic kinase Mps1

Cat. No.

A21596

CAS No.

1609584-72-6

Mps1-IN-3

Mps1-IN-3 is a potent and selective MPS1 kinase inhibitor, with an IC50 of 50 nM.

Cat. No.

A22039

CAS No.

1228817-38-6

Mps1-IN-2

Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor, with an IC50 and a Kd of 145 nM and 12 nM for Mps1 and a Kd of 61 nM for Plk1.

Cat. No.

A31381

CAS No.

1382477-96-4

Mps-BAY2a

Mps-BAY2a is a potent inhibitor of monopolar spindle 1 (MPS1) with an IC50 of 1 nM in human MPS1. This compound effectively induces mitotic aberrations and promotes apoptosis in cancer cells, making it a valuable tool for cancer research and studies focused on cell cycle regulation. Its high specificity for MPS1 underscores its potential in investigating the role of this kinase in mitotic progression and tumorigenesis.

Cat. No.

A31643

CAS No.

1309593-24-5

Mps-BAY1

Mps-BAY1 is an inhibitor of MPS1, a critical kinase involved in the regulation of cell cycle and mitosis. This compound demonstrates significant anticancer activity by inhibiting cell proliferation and inducing apoptosis through the activation of mitotic catastrophe, leading to global aneuploidy and polyploidy in cancer cells. Mps-BAY1 is applicable in research related to colorectal cancer and cervical cancer, making it a valuable tool for studying mechanisms underlying tumorigenesis and potential therapeutic strategies.

Cat. No.

A31692

CAS No.

2890819-31-3

Mps1-IN-5

Mps1-IN-5 is a selective inhibitor of Mps1 kinase, exhibiting an IC50 value of 29 nM. This compound effectively induces apoptosis and triggers cell cycle arrest at the G2/M phase, demonstrating significant antiproliferative and anti-tumor activities. Mps1-IN-5 operates by inhibiting Mps1 phosphorylation and promoting DNA damage, making it a valuable tool for cancer research and therapeutic investigations.

Cat. No.

A32974

CAS No.

2772910-13-9

PF-3837

PF-3837 is a potent Mps1 kinase inhibitor, with a Ki value of 0.33 nM and an IC50 of 5.5 nM. By inhibiting the catalytic activity of Mps1, PF-3837 disrupts cell cycle checkpoints, leading to reduced genomic stability and promoting apoptosis in cancer cells. This compound is primarily utilized in research focused on breast cancer, providing insights into cell cycle regulation and potential therapeutic interventions.

Cat. No.

A33133

CAS No.

2771955-09-8

PF-7006

PF-7006 is a potent inhibitor of Mps1 kinase, exhibiting a Ki of 0.27 nM and an IC50 of 2.5 nM. This compound disrupts cell cycle checkpoints by inhibiting Mps1's catalytic activity, resulting in decreased histone H3 levels and a reduction in mitotic duration, ultimately inducing apoptosis in cancer cells. PF-7006 demonstrates potential as a valuable tool in breast cancer research, particularly when combined with other agents that enhance therapeutic efficacy.

Cat. No.

A38180

CAS No.

1430741-35-7

CFI-401870

CFI-401870 is a potent threonine tyrosine kinase (TTK) inhibitor, demonstrating an IC50 of 3.1 nM. This compound has been shown to effectively inhibit the growth of cancer cells, leading to chromosome lag and increased aneuploidy, as well as cell cycle arrest. Research applications include the investigation of cancer mechanisms and therapeutic strategies, particularly in colon cancer studies.

Cat. No.

A55059

CAS No.

1610677-37-6

Luvixasertib hydrochloride

Synonyms: CFI-402257 hydrochloride

Luvixasertib hydrochloride is a highly selective inhibitor of TTK/Mps1, demonstrating an IC50 of 1.7 nM for TTK in vitro. This compound exhibits significant anti-cancer activity, making it a valuable tool for cancer research. Its mechanism of action targets crucial mitotic processes, providing insights into cell cycle regulation and tumorigenesis. Luvixasertib hydrochloride is suitable for studies focused on cancer biology and therapeutic development.

Cat. No.

A55060

CAS No.

1610676-27-1

CFI-401980

CFI-401980 is a selective inhibitor of the MPS1 kinase, exhibiting an affinity characterized by a Ki value of 0.8 nM. This compound effectively inhibits the proliferation of HCT116 cancer cell lines, making it a valuable tool in cancer research. CFI-401980 may be utilized to investigate the role of MPS1 in cell cycle regulation and its potential as a therapeutic target in anti-cancer strategies.

Cat. No.

A55061

CAS No.

1206170-62-8

TC-Mps1-12

TC-Mps1-12 is a highly selective inhibitor of monopolar spindle 1 (Mps1), demonstrating an IC50 of 6.4 nM. It effectively disrupts the function of Mps1, a key regulator of the mitotic spindle assembly checkpoint. This compound is valuable for studying cell cycle regulation, mitosis, and cancer biology, facilitating research into potential therapeutic targets for cancer treatment.

Cat. No.

A55062

CAS No.

1817791-73-3

NTRC 0066-0

NTRC 0066-0 is a potent inhibitor of threonine-tyrosine kinase (TTK), exhibiting an IC50 of 0.9 nM. This selective inhibitor is valuable for cancer research, offering insights into TTK-mediated signaling pathways and their role in tumorigenesis. NTRC 0066-0 enables the exploration of TTK's contribution to cell cycle regulation and cancer cell proliferation.

Cat. No.

A55063

CAS No.

1578244-34-4

Mps1-IN-7

Mps1-IN-7 is a potent inhibitor of MPS1 with an IC50 value of 0.020 μM, demonstrating selectivity over JNK1 and JNK2 (IC50 values of 0.11 μM and 0.22 μM, respectively). This compound exhibits significant antiproliferative effects across various cancer cell lines, including SW620, CAL51, Miapaca-2, and RMG1, with GI50 values of 0.065, 0.068, 0.25, and 0.110 μM, respectively. Mps1-IN-7 can be utilized in research focused on cell cycle regulation and the development of targeted cancer therapies.

Cat. No.

A55064

CAS No.

2645409-78-3

RMS-07

RMS-07 is a covalent inhibitor of Monopolar Spindle Kinase 1 (MPS1/TTK), exhibiting an apparent IC50 of 13.1 nM. It selectively targets a poorly conserved cysteine residue within the kinase's hinge region. This compound is utilized in research applications focusing on cell cycle regulation, mitotic checkpoint studies, and cancer therapeutics.

Cat. No.

A55065

CAS No.

2989453-29-2

Mps1-IN-3 hydrochloride

Mps1-IN-3 hydrochloride is a potent and selective inhibitor of Mps1, with an IC50 value of 50 nM. This compound effectively inhibits the proliferation of glioblastoma cells and enhances the sensitivity of glioblastomas to Vincristine in orthotopic glioblastoma xenograft models. Mps1-IN-3 hydrochloride is valuable for research applications targeting cell cycle regulation and glioblastoma treatment strategies.

Cat. No.

A55066

CAS No.

2489220-49-5

Mps1-IN-10

Mps1-IN-10 is a potent inhibitor of Mps1, exhibiting an IC50 of 6.4 nM. This compound effectively suppresses the proliferation of cancer cells, demonstrated by a GI50 of 11 nM in the MDA-MB-231 cell line. Mps1-IN-10 also shows significant anti-tumor efficacy in preclinical models using MDA-MB-231 xenografts, making it a valuable tool for cancer research applications focused on cell cycle regulation and tumor growth inhibition.

Cat. No.

A55067

CAS No.

2820453-41-4

TTK inhibitor 3

TTK Inhibitor 3 is a highly potent and selective inhibitor of TTK, a critical enzyme involved in the spindle assembly checkpoint. With an IC50 value of 3.0 nM, this compound effectively disrupts TTK activity, making it a valuable tool for studying cell cycle regulation and mitotic progression. Its application extends to research focused on cancer biology, particularly in the context of therapeutic approaches targeting aberrant cell division.

Cat. No.

A55068

CAS No.

1883548-93-3

Mps1-IN-1 dihydrochloride

Mps1-IN-1 dihydrochloride is a potent ATP-competitive inhibitor of Mps1 kinase, exhibiting an IC50 of 367 nM. This compound effectively inhibits Mps1 mitotic kinase activity, disrupting spindle assembly checkpoint (SAC) function and leading to compromised cell cycle regulation. Mps1-IN-1 dihydrochloride demonstrates cytotoxic effects in various cellular contexts, impacting both cancerous and normal cells, making it a valuable tool for research in cell division and cancer therapy.

Cat. No.

A55069

CAS No.

3043761-59-4

Mps1-IN-6

Mps1-IN-6 is a selective inhibitor of Mps1, exhibiting an IC50 value of 2.596 nM. This compound demonstrates significant antiproliferative effects and shows potential as an effective antitumor agent. Mps1-IN-6 is valuable for research into tumor biology and potential therapeutic interventions targeting mitotic checkpoint regulation.

Cat. No.

A55071

CAS No.

1263423-94-4

Mps1-IN-4

Mps1-IN-4 is a selective inhibitor of Monopolar spindle 1 (Mps1), a critical kinase involved in the regulation of the mitotic checkpoint. This compound exhibits antiproliferative activity, making it a valuable tool for cancer research. Mps1-IN-4 can be utilized to investigate the role of Mps1 in cell cycle regulation and its implications in tumorigenesis.

Cat. No.

A55072

CAS No.

2964520-80-5

TTK inhibitor 4

TTK inhibitor 4 is a potent inhibitor of threonine tyrosine kinase (TTK), exhibiting an IC50 value of 0.016 μM. This compound demonstrates significant anti-tumor activity, making it a valuable tool for cancer research. It is particularly relevant for studies focused on cell proliferation, apoptosis, and signal transduction pathways associated with malignancies.

Cat. No.

A55073

CAS No.

2259843-95-1

Mps1-IN-8

Mps1-IN-8 is a potent inhibitor of the Mps1 kinase, a key regulator of the spindle assembly checkpoint. It effectively impairs Mps1 activity, leading to mitotic disruption in cancer cells. This compound is valuable for investigating the role of Mps1 in tumorigenesis and exploring its potential as a therapeutic target in cancer research.