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$0.00 LRRK2
Leucine-rich repeat kinase 2 (LRRK2 or RIP7) is a member of the receptor-interacting protein kinase family. It is a large multidomain protein kinase that includes leucine-rich repeats and a GTPase domain. Mutations in LRRK2 are commonly associated with late-onset Parkinson's disease (PD). LRRK2 is also known as dardarin.
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PF-06447475
Catalog No. A15504 LRRK2 inhibitorPF-06447475 is a highly potent, selective, brain penetrant LRRK2 inhibitor with IC50 of 3 nM/11 nM for Wt LRRK2/G2019S LRRK2 respectively. Learn More -
PF-06454589
Catalog No. A22595 -
MLi-2
Catalog No. A20530 brain penetrant LRRK2 inhibitorMLi-2 is a potent, highly selective, orally available, brain penetrant inhibitor of LRRK2 with an IC50 of 0.76 nM. Learn More -
LRRK2 inhibitor 1
Catalog No. A19701 LRRK2 inhibitorLRRK2 inhibitor 1 is a potent, selective and oral LRRK2 inhibitor with an pIC50 of 6.8 nM. Learn More -
CZC54252 hydrochloride
Catalog No. A15510 LRRK2 inhibitorCZC-54252 is a potent inhibitor of LRRK2 with IC50s of 1.28 nM and 1.85 nM for wild-type and G2019S LRRK2 respectively. Learn More -
TAE684
Catalog No. A10662 ALK InhibitorTAE684 is a inhibitor of ALK and also a potent inhibitor of LRRK2 kinase activity (IC(50) of 7.8nM against wild-type LRRK2, 6.1nM against the G2019S mutant). Learn More -
LRRK2-IN-1
Catalog No. A11477 LRRK2 inhibitorLRRK2-IN-1 inhibits both G2019S mutant and wild-type LRRK2 kinase activity with IC50 values of 6 and 13 nM respectively. Learn More -
CZC-25146 hydrochloride
Catalog No. A13448 LRRK2 inhibitorCZC-25146 is a potent and selective LRRK2 inhibitor. CZC-25146 prevents mutant LRRK2-induced injury of cultured rodent and human neurons with mid-nanomolar potency. Learn More -
GNE-7915
Catalog No. A13748 LRRK2 inhibitorGNE-7915 is a Blood-Brain Barrier (BBB) penetrable small molecule inhibitor of Leucine-Rich Repeat Kinase 2 (LRRK2). Learn More -
GNE 9605
Catalog No. A14149 LRRK2 inhibitorGNE-9605 is a highly potent and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor with Ki and IC50 of 2 nM and 19 nM, respectively. Learn More -
GNE0877
Catalog No. A13969 -
JH-II-127
Catalog No. A15777 LRRK2 inhibitorJH-II-127 is a highly potent, selective, and brain penetrant LRRK2 inhibitor, with IC50 of 6.6 nM, 2.2 nM ,47.7 nM for LRRK2-wild-type, LRRK2-G2019S, LRRK2-A2016T. Learn More -
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CZC-25146
Catalog No. A17125 -
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PF-06371900
Catalog No. A17221 LRRK2 inhibitorPF-06371900 is a potent and highly selective leucine rich repeat kinase 2 (LRRK2) inhibitor. Learn More -
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PFE-360 (PF-06685360)
Catalog No. A18816 LRRK2 inhibitorPFE-360, also known asd PF-06685360, is a potent and selective inhibitor of LRRK2 kinase. Learn More -
HG-10-102-01
Catalog No. A12919 LRRK2 Inhibitor IIIHG-10-102-01 is a brain penetrant, potent and selective inhibitor of wild-type LRRK2. Learn More -
GSK2578215A
Catalog No. A12798 LRRK2 kinase inhibitorGSK2578215A is a potent leucine-rich repeat kinase 2 (LRRK2) inhibitor (IC50 values are 8.9 and 10.1 nM respectively for LRRK2[G2019S] mutant and wild-type LRRK2 respectively). Learn More
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