LRRK2

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  1. TAE684

    Catalog No. A10662
    ALK Inhibitor
    TAE684 is a inhibitor of ALK and also a potent inhibitor of LRRK2 kinase activity (IC(50) of 7.8nM against wild-type LRRK2, 6.1nM against the G2019S mutant). Learn More
  2. CZC54252 hydrochloride

    Catalog No. A15510
    LRRK2 inhibitor
    CZC-54252 is a potent inhibitor of LRRK2 with IC50s of 1.28 nM and 1.85 nM for wild-type and G2019S LRRK2 respectively. Learn More
  3. GNE-7915

    Catalog No. A13748
    LRRK2 inhibitor
    GNE-7915 is a Blood-Brain Barrier (BBB) penetrable small molecule inhibitor of Leucine-Rich Repeat Kinase 2 (LRRK2). Learn More
  4. PF-06447475

    Catalog No. A15504
    LRRK2 inhibitor
    PF-06447475 is a highly potent, selective, brain penetrant LRRK2 inhibitor with IC50 of 3 nM/11 nM for Wt LRRK2/G2019S LRRK2 respectively. Learn More
  5. CZC-25146 hydrochloride

    Catalog No. A13448
    LRRK2 inhibitor
    CZC-25146 is a potent and selective LRRK2 inhibitor. CZC-25146 prevents mutant LRRK2-induced injury of cultured rodent and human neurons with mid-nanomolar potency. Learn More
  6. LRRK2-IN-1

    Catalog No. A11477
    LRRK2 inhibitor
    LRRK2-IN-1 inhibits both G2019S mutant and wild-type LRRK2 kinase activity with IC50 values of 6 and 13 nM respectively. Learn More
  7. JH-II-127

    Catalog No. A15777
    LRRK2 inhibitor
    JH-II-127 is a highly potent, selective, and brain penetrant LRRK2 inhibitor, with IC50 of 6.6 nM, 2.2 nM ,47.7 nM for LRRK2-wild-type, LRRK2-G2019S, LRRK2-A2016T. Learn More
  8. GNE 9605

    Catalog No. A14149
    LRRK2 inhibitor
    GNE-9605 is a highly potent and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor with Ki and IC50 of 2 nM and 19 nM, respectively. Learn More
  9. GNE0877

    Catalog No. A13969
    LRRK2 inhibitor
    GNE-0877 is a highly potent and selective LRRK2 inhibitor. Learn More
  10. HG-10-102-01

    Catalog No. A12919
    LRRK2 Inhibitor III
    HG-10-102-01 is a brain penetrant, potent and selective inhibitor of wild-type LRRK2. Learn More
  11. GSK2578215A

    Catalog No. A12798
    LRRK2 kinase inhibitor
    GSK2578215A is a potent leucine-rich repeat kinase 2 (LRRK2) inhibitor (IC50 values are 8.9 and 10.1 nM respectively for LRRK2[G2019S] mutant and wild-type LRRK2 respectively). Learn More
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    CZC-25146

    Catalog No. A17125
    LRRK2 inhibitor
    CZC-25146 is a potent LRRK2 inhibitor. Learn More

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