LRRK2-IN-1

Catalog No.: A11477

LRRK2 inhibitor

LRRK2-IN-1

LRRK2-IN-1 Chemical Structure

CAS NO. 1234480-84-2

LRRK2-IN-1 inhibits both G2019S mutant and wild-type LRRK2 kinase activity with IC50 values of 6 and 13 nM respectively.

Availability: In stock

Package Price Qty
10 mg

Regular Price: $110.00

Special Price $99.00

25 mg

Regular Price: $230.00

Special Price $207.00

50 mg

Regular Price: $400.00

Special Price $360.00

10mM * 1mL in DMSO

Regular Price: $120.00

Special Price $108.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

LRRK2-IN-1 inhibits both G2019S mutant and wild-type LRRK2 kinase activity with IC50 values of 6 and 13 nM respectively.
Targets
Target Value
DCLK1IC50: 2.61nM
LRRK2(G2019S)IC50: 6nM
LRRK2(WT)IC50: 13nM
DCLK2IC50: 45nM
LRRK2(A2016T)IC50: 2.45μM
LRRK2(A2016T+G2019S)IC50: 3.08μM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.54 mL 87.71 mL 175.41 mL
0.5 mM 3.51 mL 17.54 mL 35.08 mL
1 mM 1.75 mL 8.77 mL 17.54 mL
5 mM 0.35 mL 1.75 mL 3.51 mL

*The above data is based on the productmolecular weight 570.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A11477
Actions Inhibitor
M. Wt 570.09
Formula C31H38N8O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1234480-84-2
Synonyms N/A
SMILES CN1CCN(CC1)C2CCN(CC2)C(=O)C3=CC(=C(C=C3)NC4=NC=C5C(=N4)N(C6=CC=CC=C6C(=O)N5C)C)OC

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