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$0.00 Biological Activity
LRRK2-IN-1 inhibits both G2019S mutant and wild-type LRRK2 kinase activity with IC50 values of 6 and 13 nM respectively.
Targets
| Target | Value |
|---|---|
| DCLK1 | IC50: 2.61nM |
| LRRK2(G2019S) | IC50: 6nM |
| LRRK2(WT) | IC50: 13nM |
| DCLK2 | IC50: 45nM |
| LRRK2(A2016T) | IC50: 2.45μM |
| LRRK2(A2016T+G2019S) | IC50: 3.08μM |
| In vitro (25°C) | DMSO | 97 mg/mL (169.96 mM) | |
| Water | Insoluble | ||
| Ethanol | 97 mg/mL (169.96 mM) | ||
| In vivo | Captisol | 16 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.54 mL | 87.71 mL | 175.41 mL |
| 0.5 mM | 3.51 mL | 17.54 mL | 35.08 mL |
| 1 mM | 1.75 mL | 8.77 mL | 17.54 mL |
| 5 mM | 0.35 mL | 1.75 mL | 3.51 mL |
*The above data is based on the productmolecular weight 570.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11477 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1234480-84-2 |
| Formula | C31H38N8O3 |
| M. Wt | 570.09 |
| Purity | >98% |
| SMILES | CN1CCN(CC1)C2CCN(CC2)C(=O)C3=CC(=C(C=C3)NC4=NC=C5C(=N4)N(C6=CC=CC=C6C(=O)N5C)C)OC |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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