LRRK2-IN-1

Catalog No.: A11477

LRRK2 inhibitor

LRRK2-IN-1

LRRK2-IN-1 Chemical Structure

CAS NO. 1234480-84-2

LRRK2-IN-1 inhibits both G2019S mutant and wild-type LRRK2 kinase activity with IC50 values of 6 and 13 nM respectively.

Availability: In stock

Package Price Qty
10 mg
$110.00
25 mg
$230.00
50 mg
$400.00
10mM * 1mL in DMSO
$120.00
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Biological Activity

LRRK2-IN-1 inhibits both G2019S mutant and wild-type LRRK2 kinase activity with IC50 values of 6 and 13 nM respectively.
Targets
Target Value
DCLK1IC50: 2.61nM
LRRK2(G2019S)IC50: 6nM
LRRK2(WT)IC50: 13nM
DCLK2IC50: 45nM
LRRK2(A2016T)IC50: 2.45μM
LRRK2(A2016T+G2019S)IC50: 3.08μM
In vitro (25°C) DMSO 97 mg/mL (169.96 mM)
Water Insoluble
Ethanol 97 mg/mL (169.96 mM)
In vivo Captisol 16 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.54 mL 87.71 mL 175.41 mL
0.5 mM 3.51 mL 17.54 mL 35.08 mL
1 mM 1.75 mL 8.77 mL 17.54 mL
5 mM 0.35 mL 1.75 mL 3.51 mL

*The above data is based on the productmolecular weight 570.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11477
Actions Inhibitor
CAS No. 1234480-84-2
Formula C31H38N8O3
M. Wt 570.09
Purity >98%
SMILES CN1CCN(CC1)C2CCN(CC2)C(=O)C3=CC(=C(C=C3)NC4=NC=C5C(=N4)N(C6=CC=CC=C6C(=O)N5C)C)OC
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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