Catalog No.
Product Name
Application
Product Information
Citations
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SOS1 inhibitor
BI-3406 (SOS1-IN-2) is a Son of Sevenless 1 (SOS1) inhibitor with an IC50 of 6 nM.
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SOS1 Activator
SOS1 Activator 2 engages the SOS1 protein, functioning as a potent activator with a binding affinity characterized by a Kd of 9 nM. By modulating the Ras-ERK signaling pathway, SOS1 Activator 2 serves as a valuable tool in cancer research, facilitating investigations into signal transduction mechanisms and potential therapeutic strategies. Its specificity and efficacy make it an essential reagent for studies aimed at understanding the complexities of oncogenic signaling pathways. -
SOS1-Ras Inhibitor
UC-857993 is a selective inhibitor of the SOS1-Ras interaction, effectively suppressing its catalytic activity with a Kd of 14.7 μM (His6-SOS1cat). This compound also inhibits ERK and Ras activation, demonstrating significant capabilities in reducing the proliferation of mouse embryonic fibroblasts (MEFs). UC-857993 is valuable for research into cancer biology and signaling pathways involving Ras.
