AChE

Cat. No.

A78622

CAS No.

124027-47-0

Velnacrine

Synonyms: HP 029 free base; Hydroxytacrine

Velnacrine is a potent inhibitor of acetylcholinesterase (AChE), displaying an IC50 of 3.27 μM. This compound has demonstrated the ability to reverse scopolamine-induced amnesia in rat models, highlighting its potential in cognitive research. Additionally, Velnacrine exhibits acute toxicity with an LD50 of 65 mg/kg, warranting careful handling during experimental applications.

Cat. No.

A78623

CAS No.

2924824-48-4

AChE/BChE-IN-10

AChE/BChE-IN-10 is a potent dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), demonstrating IC50 values of 0.176 μM and 0.47 μM, respectively. This compound exhibits favorable permeability across the blood-brain barrier and has been shown to inhibit amyloid-beta (Aβ) aggregation. AChE/BChE-IN-10 is valuable for research applications focused on Alzheimer’s disease and related neurodegenerative disorders.

Cat. No.

A78624

CAS No.

80443-15-8

Acacetin-7-O-β-D-galactopyranoside

Acacetin-7-O-β-D-galactopyranoside is a flavonoid known for its inhibitory activity against acetylcholinesterase (AChE). This compound, isolated from the flower heads of Chrysanthemum morifolium, shows potential for use in Alzheimer’s disease research. Its ability to modulate AChE activity makes it a valuable tool for studying cholinergic signaling and neurodegenerative processes.

Cat. No.

A78625

CAS No.

502-22-7

Carlina oxide

Carlina oxide functions as an acetylcholinesterase (AChE) inhibitor, exhibiting significant cytotoxic properties towards various cell lines, including human dermis, HCT116, and MDA-MB231. Additionally, it demonstrates potent larvicidal activity against Culex pipiens larvae, with an LC50 value of 1.39 μg/mL. This compound may be utilized in research contexts focusing on neurobiology, entomology, and cancer studies.

Cat. No.

A78626

CAS No.

70407-20-4

Territrem B

Territrem B is a fungal meroterpenoid that serves as an irreversible inhibitor of acetylcholinesterase (AChE). It is isolated from Aspergillus terreus and exhibits significant neurotoxic activity. This compound is valuable for studying AChE-related pathways and can aid in the development of therapeutic agents for neurological disorders.

Cat. No.

A78627

CAS No.

120014-30-4

ACHE-IN-38

ACHE-IN-38 is a potent inhibitor of acetylcholinesterase (AChE), acting to prevent the breakdown of the neurotransmitter acetylcholine (ACh). By inhibiting AChE, this compound enhances cholinergic transmission and has potential applications in addressing cognitive deficits associated with Alzheimer's Disease. It serves as a valuable tool in neuroscience research focused on memory disorders and cholinergic system modulation.

Cat. No.

A78628

CAS No.

920845-86-9

Z32439948

Z32439948 is a butyrylcholinesterase (BChE) inhibitor with an IC50 of 1.4 μM against human BChE. This compound, a derivative of m-sulfamoylbenzamide, demonstrates neuroprotective properties, particularly against glutamate-induced toxicity in SH-SY5Y neuronal cell lines. Z32439948 is valuable for research in neurodegenerative disease models and therapeutic strategies targeting cholinergic dysfunction.

Cat. No.

A78629

CAS No.

2720624-42-8

AChE/BChE-IN-1

AChE/BChE-IN-1 is a potent dual inhibitor of Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE), demonstrating IC50 values of 1.06 nM and 7.3 nM, respectively, for human enzymes. This compound exhibits brain penetrance and is also characterized by its antioxidant properties. AChE/BChE-IN-1 is valuable for research focused on Alzheimer’s disease and related neurological disorders, providing insights into cholinergic system modulation.

Cat. No.

A78630

CAS No.

1997158-25-4

AChE/BuChE-IN-4

AChE/BuChE-IN-4 is a multitarget-directed inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), exhibiting IC50 values of 2.08 μM and 7.41 μM, respectively. This compound plays a significant role in studies related to neurodegenerative disorders and cholinergic signaling pathways. Its dual inhibition of AChE and BuChE makes it a valuable tool for research into therapeutic strategies for diseases such as Alzheimer's and other cognitive impairments.

Cat. No.

A78631

CAS No.

1794779-85-3

Chlorpyrifos-oxon-d10

Chlorpyrifos-oxon-d10 is a deuterium-labeled derivative of Chlorpyrifos-oxon, which serves as a potent inhibitor of acetylcholinesterase (AChE) through phosphorylating action. This compound has been shown to induce cross-linking between tubulin subunits, thereby disrupting microtubule dynamics and function. Its use in research applications includes studying the mechanisms of neurotoxicity and the evaluation of pesticide metabolism.

Cat. No.

A78632

CAS No.

19843-03-9

Dehydrodicentrine

Dehydrodicentrine is an aporphine alkaloid that acts as an acetylcholinesterase (AChE) inhibitor, exhibiting an IC50 value of 2.98 μM. This compound is derived from the root of S. epigaea and demonstrates potential in studies related to neurological disorders and pain management. Its ability to modulate AChE activity makes it a valuable tool for research applications focused on cholinergic neurotransmission.

Cat. No.

A78633

CAS No.

2925298-08-2

SB-1436

SB-1436 is a potent cholinesterase inhibitor targeting acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50 values of 0.176 μM and 0.37 μM, respectively. It inhibits these enzymes in a non-competitive manner, exhibiting Kis of 0.046 μM for AChE and 0.115 μM for BChE. Additionally, SB-1436 significantly reduces the self-aggregation of amyloid-beta (Aβ), making it a valuable tool for research in neurological diseases and related therapeutic applications.

Cat. No.

A78634

CAS No.

177028-90-9

AChE-IN-27

AChE-IN-27 is a potent acetylcholinesterase (AChE) inhibitor with an IC50 value of 0.19 µM. This compound is specifically designed for research into neurological disorders, making it valuable for studies related to Alzheimer's disease, dementia, ataxia, and myasthenia gravis. Its ability to inhibit AChE provides a useful tool for investigating cholinergic signaling and developing potential therapeutic strategies for these conditions.

Cat. No.

A78635

CAS No.

7270-83-9

7-Acetoxy-1-methylquinolinium iodide

Synonyms: AMQI

7-Acetoxy-1-methylquinolinium iodide is a fluorogenic substrate specifically targeting cholinesterase. Upon hydrolysis, it emits fluorescence at 410 nm when excited at 320 nm, facilitating the detection and identification of cholinesterase inhibitors. This compound is widely utilized in fluorometric assays, contributing significantly to biochemical research and drug discovery efforts focused on cholinergic pathways.

Cat. No.

A78636

CAS No.

78134-82-4

Dehydrodiscretamine chloride

Dehydrodiscretamine chloride is a dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), exhibiting IC50 values of 17.8 μM and 118.8 μM, respectively. This compound also possesses antioxidant activity, making it relevant for research into neurodegenerative diseases. Its potential applications include studies focused on Alzheimer’s disease and exploring pathways of cholinergic dysfunction.

Cat. No.

A78637

CAS No.

2416910-85-3

BChE-IN-7

BChE-IN-7 is a selective inhibitor of butyrylcholinesterase (BChE) that effectively penetrates the blood-brain barrier. With an IC50 of 0.06 μM for BChE, this reversible inhibitor demonstrates significant neuroprotective effects against toxic amyloid-beta species in neuronal-like cells. It serves as a valuable tool for research in neurodegenerative diseases and the modulation of cholinergic pathways.

Cat. No.

A78639

CAS No.

89505-76-0

Lycoramine hydrobromide

Lycoramine hydrobromide is a potent acetylcholinesterase (AChE) inhibitor derived from Lycoris radiata. This compound serves as a valuable tool in the study of neurological disorders by enhancing cholinergic signaling through the inhibition of AChE activity. Its application in research includes investigating cognitive function, Alzheimer's disease, and other conditions associated with cholinergic deficits.

Cat. No.

A78640

CAS No.

2421121-10-8

BChE-IN-6

BChE-IN-6 is a potent butyrylcholinesterase (BChE) inhibitor, exhibiting a Ki of 0.182 μM. This compound possesses chelating properties for Zn2+, making it a valuable tool for studying metal interactions in biological systems. BChE-IN-6 is primarily utilized in Alzheimer's disease research, aiding in the investigation of cholinergic dysfunction and potential therapeutic interventions.

Cat. No.

A78641

CAS No.

23505-41-1

Pirimiphos ethyl

Pirimiphos ethyl is an organophosphorus compound that functions as an acetylcholinesterase inhibitor. Its primary biological activity involves disrupting the normal hydrolysis of acetylcholine, resulting in prolonged neurotransmission at cholinergic synapses. This reagent is utilized extensively in agricultural research to study the effects of pesticide exposure on neurological pathways and to assess the ecological impact of pesticide application.

Cat. No.

A78642

CAS No.

1801157-64-1

Dual AChE-MAO B-IN-2

Dual AChE-MAO B-IN-2 is a powerful inhibitor of both acetylcholinesterase (AChE) and monoamine oxidase B (MAO B), exhibiting IC50 values of 0.12 µM and 0.01 µM, respectively. This dual inhibition profile suggests its significant potential in the study and development of therapeutic strategies for Alzheimer's disease. Researchers can utilize Dual AChE-MAO B-IN-2 to explore mechanisms related to cholinergic dysfunction and oxidative stress in neurodegenerative conditions.

Cat. No.

A78643

CAS No.

126722-26-7

Pumiloside

Pumiloside is a natural compound isolated from Nauclea officinalis that functions as an acetylcholinesterase (AChE) inhibitor, demonstrating an IC50 value of 118.36 μM. This compound is of significant interest for research applications related to neurodegenerative disorders, where modulation of cholinergic signaling may be beneficial. Pumiloside's ability to inhibit AChE positions it as a potential candidate for the development of therapeutic agents targeting cognitive decline.

Cat. No.

A78644

CAS No.

513-10-0

Echothiopate iodide

Synonyms: Echothiophate iodide

Echothiopate iodide is a potent inhibitor of human butyrylcholinesterase (hBChE), known for its ability to prolong cholinergic activity. As a long-acting anticholinesterase agent, this compound is particularly relevant in studies related to glaucoma and acetylcholine signaling pathways. Its inhibitory effects make it a valuable tool for investigating cholinergic modulation and potential therapeutic interventions in related disorders.

Cat. No.

A78645

CAS No.

2699090-78-1

AChE-IN-7

AChE-IN-7 is a highly selective and potent inhibitor of acetylcholinesterase with an eeAChE IC50 value of 0.045 μM and an eeBuChE IC50 of 19.68 μM. This compound demonstrates promising in vivo and in vitro safety profiles, along with favorable pharmacokinetic characteristics and high bioavailability (F = 55.5%). Additionally, AChE-IN-7 exhibits significant permeability across the blood-brain barrier, making it a valuable tool for research into neurological disorders and therapeutic strategies targeting cholinergic signaling.

Cat. No.

A78646

CAS No.

2758685-58-2

AChE-IN-44

AChE-IN-44 is a potent acetylcholinesterase (AChE) inhibitor. It effectively enhances cholinergic neurotransmission by inhibiting the breakdown of acetylcholine, making it valuable for research in neurodegenerative diseases such as Alzheimer's. Additionally, AChE-IN-44 can be transformed into the thiazole salt derivative, AChE inhibitor Tat2, expanding its potential applications in pharmacological studies.

Cat. No.

A78647

CAS No.

2140327-42-8

Profenofos-d3

Profenofos-d3 is a stable isotope-labeled derivative of Profenofos, an insecticide known for its application in field crops, vegetables, and fruit crops. It functions as an acetylcholinesterase (AChE) inhibitor, exhibiting neurotoxic effects that can impact insect populations. This reagent is valuable for research applications involving pharmacokinetics and metabolic studies of insecticides, enabling precise tracking in biological systems.