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Biological Activity
WYE-354 is a potent cell-permeable inhibitor of mTOR (IC50 = 4.3 nM) which blocks signaling through both mTOR complex 1 (mTORC1) and mTORC2. It is a much weaker inhibitor of PI3K α (IC50 = 1026 nM) and other kinases.
Targets
Target | Value |
---|---|
mTOR | IC50: 5nM |
PI3Kα | IC50: 1.89μM |
PI3Kγ | IC50: 7.37μM |
GCK | IC50: >50μM |
Hck | IC50: >50μM |
IKKα | IC50: >50μM |
Lyn | IC50: >50μM |
Met | IC50: >50μM |
MK2 | IC50: >50μM |
p38α | IC50: >50μM |
PDGFRα | IC50: >50μM |
PKA | IC50: >50μM |
PKBα | IC50: >50μM |
PKCα | IC50: >50μM |
PKCβ | IC50: >50μM |
ROCK1 | IC50: >50μM |
RSK1 | IC50: >50μM |
Src | IC50: >50μM |
VEGFR2 | IC50: >50μM |
Abl1 | IC50: >50μM |
AuroraB | IC50: >50μM |
CDK1/CyclinB | IC50: >50μM |
CDK2/CyclinA | IC50: >50μM |
Chk1 | IC50: >50μM |
ERK2 | IC50: >50μM |
Fyn | IC50: >50μM |
In vitro (25°C) | DMSO | 95 mg/mL (191.71 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 4% DMSO+30% PEG 300+5% Tween 80+ddH2O | 4 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 20.18 mL | 100.91 mL | 201.82 mL |
0.5 mM | 4.04 mL | 20.18 mL | 40.36 mL |
1 mM | 2.02 mL | 10.09 mL | 20.18 mL |
5 mM | 0.4 mL | 2.02 mL | 4.04 mL |
*The above data is based on the productmolecular weight 495.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10989 |
---|---|
Actions | Inhibitor |
CAS No. | 1062169-56-5 |
Formula | C24H29N7O5 |
M. Wt | 495.5 |
Purity | >98% |
Synonyms | WYE354 |
SMILES | COC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCN(CC4)C(=O)OC)C(=N2)N5CCOCC5 |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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