WYE-354

WYE-354 Chemical Structure

CAS NO. 1062169-56-5

WYE-354 is a potent cell-permeable inhibitor of mTOR (IC50 = 4.3 nM) which blocks signaling through both mTOR complex 1 (mTORC1) and mTORC2. It is a much weaker inhibitor of PI3K α (IC50 = 1026 nM) and other kinases.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $60.00

Special Price $54.00

10 mg

Regular Price: $100.00

Special Price $90.00

25 mg

Regular Price: $220.00

Special Price $198.00

50 mg

Regular Price: $400.00

Special Price $360.00

10mM * 1mL in DMSO

Regular Price: $118.00

Special Price $106.20

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

WYE-354 is a potent cell-permeable inhibitor of mTOR (IC50 = 4.3 nM) which blocks signaling through both mTOR complex 1 (mTORC1) and mTORC2. It is a much weaker inhibitor of PI3K α (IC50 = 1026 nM) and other kinases.
Targets
Target Value
mTORIC50: 5nM
PI3KαIC50: 1.89μM
PI3KγIC50: 7.37μM
GCKIC50: >50μM
HckIC50: >50μM
IKKαIC50: >50μM
LynIC50: >50μM
MetIC50: >50μM
MK2IC50: >50μM
p38αIC50: >50μM
PDGFRαIC50: >50μM
PKAIC50: >50μM
PKBαIC50: >50μM
PKCαIC50: >50μM
PKCβIC50: >50μM
ROCK1IC50: >50μM
RSK1IC50: >50μM
SrcIC50: >50μM
VEGFR2IC50: >50μM
Abl1IC50: >50μM
AuroraBIC50: >50μM
CDK1/CyclinBIC50: >50μM
CDK2/CyclinAIC50: >50μM
Chk1IC50: >50μM
ERK2IC50: >50μM
FynIC50: >50μM
In vitro (25°C) DMSO 99 mg/mL (199.78 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.18 mL 100.91 mL 201.82 mL
0.5 mM 4.04 mL 20.18 mL 40.36 mL
1 mM 2.02 mL 10.09 mL 20.18 mL
5 mM 0.4 mL 2.02 mL 4.04 mL

*The above data is based on the productmolecular weight 495.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10989
Actions Inhibitor
M. Wt 495.5
Formula C24H29N7O5
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1062169-56-5
Synonyms WYE354
SMILES COC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCN(CC4)C(=O)OC)C(=N2)N5CCOCC5

Product Tags

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
Keywords:buy WYE-354 | WYE-354 Supplier | purchase WYE-354 | WYE-354 cost | WYE-354 manufacturer | order WYE-354 | WYE-354 distributor | buy 1062169-56-5| 1062169-56-5 Supplier | purchase 1062169-56-5 | 1062169-56-5 cost | 1062169-56-5 manufacturer | order 1062169-56-5 | 1062169-56-5 distributor
Rewards