WYE-354

Catalog No.: A10989
mTOR Inhibitor
WYE-354 is a potent cell-permeable inhibitor of mTOR (IC50 = 4.3 nM) which blocks signaling through both mTOR complex 1 (mTORC1) and mTORC2. It is a much weaker inhibitor of PI3K α (IC50 = 1026 nM) and other kinases.
Grouped product items
Product Name Price Stock Qty
WYE-354 5mg
Special Price $40.00 Regular Price $50.00
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WYE-354 10mg
Special Price $64.00 Regular Price $80.00
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WYE-354 25mg
Special Price $152.00 Regular Price $190.00
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WYE-354 50mg
Special Price $280.00 Regular Price $350.00
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WYE-354 10mM * 1mL in DMSO
Special Price $94.40 Regular Price $118.00
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Biological Activity
Discription WYE-354 is a potent cell-permeable inhibitor of mTOR (IC50 = 4.3 nM) which blocks signaling through both mTOR complex 1 (mTORC1) and mTORC2. It is a much weaker inhibitor of PI3K α (IC50 = 1026 nM) and other kinases.
Targets
Target Value
Product Information
Catalog Num A10989
Formula C24H29N7O5
Molecular Weight 495.5
CAS Number 1062169-56-5
SMILES COC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCN(CC4)C(=O)OC)C(=N2)N5CCOCC5
Synonyms WYE354
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO 95 mg/mL (191.71 mM)
Water Insoluble
Ethanol Insoluble
In vivo 4% DMSO+30% PEG 300+5% Tween 80+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.18 mL 100.91 mL 201.82 mL
0.5 mM 4.04 mL 20.18 mL 40.36 mL
1 mM 2.02 mL 10.09 mL 20.18 mL
5 mM 0.4 mL 2.02 mL 4.04 mL
Useful Calculator

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