AR-A 014418

Catalog No.: A13728

GSK-3 inhibitor

AR-A 014418

AR-A 014418 Chemical Structure

CAS NO. 487021-52-3

AR-A 014418 is a selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50 = 104 nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC50 values are > 100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices.

Availability: In stock

Package Price Qty
10 mg
$60.00
25 mg
$120.00
50 mg
$200.00
100 mg
$350.00
10mM * 1mL in DMSO
$60.00
Custom Size Get quote

Free Overnight Delivery on orders over $500

Next day delivery by 10:00 a.m. Order now.

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Chia-Hui Huang, .et al. Arsenic Trioxide-Induced p38 MAPK and Akt Mediated MCL1 Downregulation Causes Apoptosis of BCR-ABL1-positive Leukemia Cells, Toxicol Appl Pharmacol, 2020, Apr 17;397:115013 PMID: 32305283

Biological Activity

AR-A 014418 is a selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50 = 104 nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC50 values are > 100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices.
Targets
GSK-3β (Cell-free assay) GSK-3β (Cell-free assay)
38 nM(Ki)38 nM(Ki)
In vitro DMSO 62 mg/mL (201.09 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 32.43 mL 162.17 mL 324.35 mL
0.5 mM 6.49 mL 32.43 mL 64.87 mL
1 mM 3.24 mL 16.22 mL 32.43 mL
5 mM 0.65 mL 3.24 mL 6.49 mL

*The above data is based on the productmolecular weight 308.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13728
Actions Inhibitor
M. Wt 308.31
Formula C12H12N4O4S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 487021-52-3
Synonyms AR-A014418, ARA 014418, ARA014418
SMILES COC1=CC=C(C=C1)CNC(=O)NC2=NC=C(S2)[N+](=O)[O-]

Product Tags

Product Tags

Other people marked this product with these tags:

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
Keywords:buy AR-A 014418 | AR-A 014418 Supplier | purchase | cost | manufacturer | order | distributor | buy 487021-52-3| 487021-52-3 Supplier | purchase 487021-52-3 | 487021-52-3 cost | 487021-52-3 manufacturer | order 487021-52-3 | 487021-52-3 distributor
Rewards