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BKM120 (NVP-BKM120, Buparlisib)
Catalog No.: A11016
PI3K Inhibitor?€?
BKM120 (NVP-BKM120) is a bioavailable specific oral pan-class I phosphatidylinositol 3-kinase (
PI3K ) kinase inhibitor.
Adooq Products cited in reputable paper
Adooq's BKM120 (NVP-BKM120, Buparlisib) has been cited by 13 publications
Kevin J Pridham, .et al. , iScience , 2024, May 7;27(6):109921 PMID: 38812542 Danielle H Oh, .et al. , PNAS , 2023, Sep 5;120(36):e2306414120 PMID: 37643213 Giri R. Gnawali, .et al. , Medicinal Chemistry Research , 2022, 31: 1154-1175 Yusuke Murase, .et al. , Oncol Rep , 2022, Apr;47(4):61 PMID: 35088890 Jeremiah J Bearss, .et al. , EMBO Rep , 2021, Apr 7;22(4):e50835 PMID: 33586867 Takaaki Fujimura, .et al. , Cancer Biol Ther , 2020, Sep 1;21(9):863-870 PMID: 32835580 Nachi Namatame, .et al. , Oncotarget , 2018, Oct 12; 9(80): 35141-35161 PMID: 30416685 Jin H. Song, .et al. , Mol Cancer Ther , 2018, Dec;17(12):2710-2721 PMID: 30190422 Saijo A, .et al. , Cancer Lett , 2018, May 1;421:17-27 PMID: 29448000 Hirosumi Tamura, .et al. , Oncol Rep , 2018, Aug; 40(2): 635-646 PMID: 29917168 Pridham KJ, .et al. , Neuro Oncol , 2018, Mar 27;20(4):494-505 PMID: 29016844 Charles-André Philip, .et al. , BMC Cancer , 2017, 17: 638 PMID: 28886696 Rogers HA, .et al. , Clin Cancer Res. , 2013, Dec 1;19(23):6450-60 PMID: 24077346
Biological Activity
Discription
BKM120 (NVP-BKM120) is a bioavailable specific oral pan-class I phosphatidylinositol 3-kinase (PI3K) kinase inhibitor.
Targets
Solubility
In vitro (25°C)
DMSO
76 mg/mL (185.18 mM)
Water
Insoluble
Ethanol
2 mg/mL (4.87 mM)
In vivo
5% DMSO+30% PEG 300+ddH2O
14 mg/mL
* <1 mg/ml means slightly soluble or insoluble.* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass
1 mg
5 mg
10 mg
0.1 mM
24.37 mL
121.83 mL
243.66 mL
0.5 mM
4.87 mL
24.37 mL
48.73 mL
1 mM
2.44 mL
12.18 mL
24.37 mL
5 mM
0.49 mL
2.44 mL
4.87 mL
Useful Calculator
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
* Please check COA/MSDS for correct molecular weight.
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1 V1 = C2 V2
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