BKM120 (NVP-BKM120, Buparlisib)

BKM120 (NVP-BKM120) is a bioavailable specific oral pan-class I phosphatidylinositol 3-kinase (PI3K) kinase inhibitor.
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Product Name Price Stock Qty
BKM120 5mg
$60.00
In stock
BKM120 10mg
$90.00
In stock
BKM120 25mg
$100.00
In stock
BKM120 50mg
$120.00
In stock
BKM120 (NVP-BKM120) 10mM * 1mL in DMSO
$60.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's BKM120 (NVP-BKM120, Buparlisib) has been cited by 11 publications
  • Giri R. Gnawali, .et al. , Medicinal Chemistry Research, 2022, 31: 1154-1175
  • Yusuke Murase, .et al. , Oncol Rep, 2022, Apr;47(4):61 PMID: 35088890
  • Jeremiah J Bearss, .et al. , EMBO Rep, 2021, Apr 7;22(4):e50835 PMID: 33586867
  • Takaaki Fujimura, .et al. , Cancer Biol Ther, 2020, Sep 1;21(9):863-870 PMID: 32835580
  • Nachi Namatame, .et al. , Oncotarget, 2018, Oct 12; 9(80): 35141-35161 PMID: 30416685
  • Jin H. Song, .et al. , Mol Cancer Ther, 2018, Dec;17(12):2710-2721 PMID: 30190422
  • Saijo A, .et al. , Cancer Lett, 2018, May 1;421:17-27 PMID: 29448000
  • Hirosumi Tamura, .et al. , Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168
  • Pridham KJ, .et al. , Neuro Oncol, 2018, Mar 27;20(4):494-505 PMID: 29016844
  • Charles-André Philip, .et al. , BMC Cancer, 2017, 17: 638 PMID: 28886696
  • Rogers HA, .et al. , Clin Cancer Res., 2013, Dec 1;19(23):6450-60 PMID: 24077346
  • Biological Activity
    Discription BKM120 (NVP-BKM120) is a bioavailable specific oral pan-class I phosphatidylinositol 3-kinase (PI3K) kinase inhibitor.
    Targets
    Target Value
    Product Information
    Catalog Num A11016
    Formula C18H21F3N6O2
    Molecular Weight 410.4
    CAS Number 944396-07-0
    SMILES C1COCCN1C2=NC(=NC(=C2)C3=CN=C(C=C3C(F)(F)F)N)N4CCOCC4
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 76 mg/mL (185.18 mM)
    Water Insoluble
    Ethanol 2 mg/mL (4.87 mM)
    In vivo 5% DMSO+30% PEG 300+ddH2O 14 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 24.37 mL 121.83 mL 243.66 mL
    0.5 mM 4.87 mL 24.37 mL 48.73 mL
    1 mM 2.44 mL 12.18 mL 24.37 mL
    5 mM 0.49 mL 2.44 mL 4.87 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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