BKM120 (NVP-BKM120, Buparlisib)

Catalog No.: A11016

PI3K Inhibitor‎

BKM120 (NVP-BKM120, Buparlisib)

BKM120 (NVP-BKM120, Buparlisib) Chemical Structure

CAS NO. 944396-07-0

BKM120 (NVP-BKM120) is a bioavailable specific oral pan-class I phosphatidylinositol 3-kinase (PI3K) kinase inhibitor.

Availability: In stock

Package Price Qty
5 mg
$60.00
10 mg
$90.00
25 mg
$100.00
50 mg
$120.00
10mM * 1mL in DMSO
$60.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Nachi Namatame, .et al. Antitumor profile of the PI3K inhibitor ZSTK474 in human sarcoma cell lines, Oncotarget, 2018, Oct 12; 9(80): 35141-35161 PMID: 30416685
  • Jin H. Song, .et al. Mechanisms Behind Resistance to PI3K Inhibitor Treatment Induced by the PIM Kinase, Mol Cancer Ther, 2018, Dec;17(12):2710-2721 PMID: 30190422
  • Saijo A, .et al. Bone marrow-derived fibrocytes promote stem cell-like properties of lung cancer cells, Cancer Lett, 2018, May 1;421:17-27 PMID: 29448000
  • Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168
  • Pridham KJ, .et al. PIK3CB/p110β is a selective survival factor for glioblastoma, Neuro Oncol, 2018, Mar 27;20(4):494-505 PMID: 29016844
  • Charles-André Philip, .et al. Inhibition of PI3K-AKT-mTOR pathway sensitizes endometrial cancer cell lines to PARP inhibitors, BMC Cancer, 2017, 17: 638 PMID: 28886696
  • Rogers HA, .et al. PI3K pathway activation provides a novel therapeutic target for pediatric ependymoma and is an independent marker of progression-free survival., Clin Cancer Res., 2013, Dec 1;19(23):6450-60 PMID: 24077346

Biological Activity

BKM120 (NVP-BKM120) is a bioavailable specific oral pan-class I phosphatidylinositol 3-kinase (PI3K) kinase inhibitor.
Targets
Target Value
p110αIC50: 52nM
p110δIC50: 116nM
p110βIC50: 166nM
p110γIC50: 262nM
Vps34IC50: 2.4μM
mTORIC50: 4.6μM
DNA-PKIC50: >5μM
PI4KβIC50: >25μM
In vitro (25°C) DMSO 82 mg/mL (199.8 mM)
Water <1 mg/mL (<1 mM)
Ethanol 2 mg/mL (4.87 mM)
In vivo 0.5% CMC Na 6 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.37 mL 121.83 mL 243.66 mL
0.5 mM 4.87 mL 24.37 mL 48.73 mL
1 mM 2.44 mL 12.18 mL 24.37 mL
5 mM 0.49 mL 2.44 mL 4.87 mL

*The above data is based on the productmolecular weight 410.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11016
Actions Inhibitor
M. Wt 410.4
Formula C18H21F3N6O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 944396-07-0
SMILES C1COCCN1C2=NC(=NC(=C2)C3=CN=C(C=C3C(F)(F)F)N)N4CCOCC4

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