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- Pirbhoy PS, .et al. Synaptically driven phosphorylation of ribosomal protein S6 is differentially regulated at active synapses versus dendrites and cell bodies by MAPK and PI3K/mTOR signaling pathways, Learn Mem, 2017, Aug; 24(8): 341-357 PMID: 28716954
Biological Activity
SL 0101-1 is a selective inhibitor of p90 ribosomal S6 kinase (RSK) (IC50 = 89 nM for RSK2). It also inhibits the growth of MCF-7 human breast cancer cells with no effect on the normal breast cell line.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 19.36 mL | 96.81 mL | 193.63 mL |
0.5 mM | 3.87 mL | 19.36 mL | 38.73 mL |
1 mM | 1.94 mL | 9.68 mL | 19.36 mL |
5 mM | 0.39 mL | 1.94 mL | 3.87 mL |
*The above data is based on the productmolecular weight 516.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A11160 |
---|---|
Actions | Inhibitor |
CAS No. | 77307-50-7 |
Formula | C25H24O12 |
M. Wt | 516.45 |
Purity | >98% |
Synonyms | SL0101-1 |
SMILES | C[[email protected]]1[[email protected]@H]([[email protected]]([[email protected]]([[email protected]@H](O1)OC2=C(OC3=CC(=CC(=C3C2=O)O)O)C4=CC=C(C=C4)O)O)OC(=O)C)OC(=O)C |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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