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- Pirbhoy PS, .et al. Synaptically driven phosphorylation of ribosomal protein S6 is differentially regulated at active synapses versus dendrites and cell bodies by MAPK and PI3K/mTOR signaling pathways, Learn Mem, 2017, Aug; 24(8): 341-357 PMID: 28716954
|Storage||at -20°C 3 years Powder|
|SMILES||C[[email protected]]1[[email protected]@H]([[email protected]]([[email protected]]([[email protected]@H](O1)OC2=C(OC3=CC(=CC(=C3C2=O)O)O)C4=CC=C(C=C4)O)O)OC(=O)C)OC(=O)C|
SL 0101-1 is a selective inhibitor of p90 ribosomal S6 kinase (RSK) (IC50 = 89 nM for RSK2). It also inhibits the growth of MCF-7 human breast cancer cells with no effect on the normal breast cell line.
Preparing Stock Solutions
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||19.36 mL||96.81 mL||193.63mL|
|0.5 mM||3.87 mL||19.36 mL||38.73 mL|
|1 mM||1.94 mL||9.68 mL||19.36 mL|
|5 mM||0.39 mL||1.94 mL||3.87 mL|
*The above data is based on the productmolecular weight 516.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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