Proteasome

Cat. No.

A11043

CAS No.

133407-82-6

MG-132

Synonyms: Z-Leu-Leu-Leu-CHO; Z-LLL-CHO

MG-132 is a potent cell-permeable inhibitor of proteasome (IC50 = 100 nM) and calpain (IC50 = 1.2 μM).

Cat. No.

A10160

CAS No.

179324-69-7

Bortezomib (Velcade)

Synonyms: MG-341; PS-341; Velcade

Bortezomib is a highly selective, reversible inhibitor of the 26S proteasome

Cat. No.

A11278

CAS No.

868540-17-4

Carfilzomib (PR-171)

Synonyms: PR-171-007; PR-171

PR-171 (Carfilzomib) is a tetrapeptide epoxyketone and a selective proteasome inhibitor. It is an analog of epoxomicin.

Cat. No.

A12653

CAS No.

960374-59-8

ONX-0914

Synonyms: PR-957

ONX 0914 is an immunoproteasome inhibitor with potential treatment applications in autoimmune disorders, such as rheumatoid arthritis, inflammatory bowel disease and lupus. ONX 0914 was designed to be a potent inhibitor of the immunoproteasome with minimal cross-reactivity for the constitutive proteasome.

Cat. No.

A10600

CAS No.

1072833-77-2

Ixazomib (MLN2238)

Synonyms: MLN2238

MLN2238 is a potent reversible and specific β5 site of the 20S proteasome inhibitor with an IC50 value of 3.4 nM.

Cat. No.

A12730

CAS No.

134381-21-8

Epoxomicin

Synonyms: BU-4061T

Epoxomicin is a potent anti-tumor agent isolated from Actinomycetes that is used as a selective and irreversible inhibitor of the 20S proteasome.

Cat. No.

A12768

CAS No.

133343-34-7

Lactacystin

Lactacystin is a cell-permeable, potent and selective proteasome inhibitor.

Cat. No.

A13853

CAS No.

437742-34-2

Marizomib (NPI-0052, salinosporamide A)

Synonyms: ML 858; NPI 0052; Salinosporamide A

Marizomib is a naturally-occurring salinosporamide, isolated from the marine actinomycete Salinospora tropica, with potential antineoplastic activity.

Cat. No.

A10602

CAS No.

1201902-80-8

Ixazomib Citrate (MLN9708) Analogue

Ixazomib Citrate (MLN9708) Analogue is a proteasome inhibitor, which inhibits the activity of the proteasome, blocking the targeted proteolysis normally performed by the proteasome.

Cat. No.

A11145

CAS No.

847499-27-8

Delanzomib (CEP-18770)

Synonyms: CEP18770

CEP-18770 is a novel orally active proteasome inhibitor with a favorable tumor selectivity profile for the treatment of MM and other malignancies responsive to proteasome inhibition.

Cat. No.

A11601

CAS No.

133407-86-0

MG-115

Synonyms: Carbobenzoxy-L-leucyl-L-leucyl-L-norvalinal; Z-LL-Nva-CHO; Proteasome Inhibitor XII,MG115

MG-115 is a potent, reversible peptide aldehyde inhibitor of proteasome chymotrypsin-like and caspase-like activities. It induces p53 dependent apoptosis.

Cat. No.

A12199

CAS No.

1449-05-4

18α-Glycyrrhetinic acid

Synonyms: 18α-GA

18α-Glycyrrhetinic acid (18α-GA) is a bioactive triterpenoid found in licorice. It shows selective inhibition of 11-HSD1 (11-hydroxysteroid dehydrogenase 1).

Cat. No.

A12220

CAS No.

179324-22-2

MG-262

Synonyms: PS-III

MG-262, a boronic peptide acid, is a potent proteasome inhibitor that selectively and reversibly inhibits the chymotryptic activity of the proteasome.

Cat. No.

A12254

CAS No.

374080-21-4

Proteasome-IN-1

Proteasome-IN-1 is a proteasome inhibitor extracted from patent WO 2013142376 A1.

Cat. No.

A12287

CAS No.

1617495-03-0

RA190

RA190, a bis-benzylidine piperidon, inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13.

Cat. No.

A13650

CAS No.

1624602-30-7

VR23

VR23 is a small molecule that potently inhibited the activities of trypsin-like proteasomes (IC50 = 1 nM), chymotrypsin-like proteasomes (IC50 = 50-100 nM), and caspase-like proteasomes (IC50 = 3uM).

Cat. No.

A13711

CAS No.

67-99-2

Gliotoxin

Synonyms: Aspergillin; S.N. 12870

Gliotoxin is an immunosuppressive mycotoxin produced by pathogenic strains of Aspergillus and other fungi.

Cat. No.

A14048

CAS No.

158442-41-2

PSI

PSI is a proteasome inhibitor that inhibits chymotrypsin-like activity of the proteasome.

Cat. No.

A14146

CAS No.

1401223-22-0

PI-1840

PI-1840 is a novel noncovalent and rapidly reversible proteasome inhibitor with anti-tumor activity.

Cat. No.

A14181

CAS No.

935888-69-0

Oprozomib (ONX 0912)

Synonyms: ONX-0912

ONX 0912 is a tripeptide epoxyketone, which inhibits growth and induces apoptosis in MM cells resistant to conventional and bortezomib therapies.

Cat. No.

A14910

CAS No.

57576-44-0

Aclacinomycin A

Synonyms: Jaclacin; Aclarubicin

Aclarubicin A, an anthracycline drug, specific inhibitor of the 20S proteasome chymotrypsin-like activity.

Cat. No.

A14922

CAS No.

856849-35-9

AM 114

AM 114, a derivative of boronic chalcone, is a potent small-molecule inhibitor of the proteasome that inhibits the chymotrypsin-like activity of the 20S proteasome, with a value of 50% inhibition concentration IC50 of approximately 1 uM, resulting in a significant accumulation of ubiquitinated p53 and other cellular proteins in whole cells without significantly disrupting the interaction of p53 and murine double minute 2 (mdm2) proteins.

Cat. No.

A14932

CAS No.

126463-64-7

Dihydroeponemycin

Dihydroeponemycin is an inhibitor of proteasome and antitumor reagent.

Cat. No.

A15427

CAS No.

154226-60-5

Clasto-Lactacystin b-lactone

Synonyms: Omuralide

Clasto-lactacystin b-lactone was later identified as the active metabolite of lactacystin, resulting from the elimination of cysteine and the formation of a reactive b-lactone.

Cat. No.

A18017

CAS No.

1239908-20-3

Ixazomib citrate (MLN9708)

Synonyms: MLN9708

Ixazomib citrate (MLN9708) is a reversible inhibitor of the chymotrypsin-like proteolytic β5 site of the 20S proteasome with an IC50 of 3.4 nM and a Ki of 0.93 nM.