AM 114

Catalog No.: A14922

20S proteasome inhibitor

AM 114

AM 114 Chemical Structure

CAS NO. 856849-35-9

AM 114, a derivative of boronic chalcone, is a potent small-molecule inhibitor of the proteasome that inhibits the chymotrypsin-like activity of the 20S proteasome, with a value of 50% inhibition concentration IC50 of approximately 1 uM, resulting in a significant accumulation of ubiquitinated p53 and other cellular proteins in whole cells without significantly disrupting the interaction of p53 and murine double minute 2 (mdm2) proteins.

Availability: In stock

Package Price Qty
10 mg
$60.00
25 mg
$120.00
50 mg
$200.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

AM 114, a derivative of boronic chalcone, is a potent small-molecule inhibitor of the proteasome that inhibits the chymotrypsin-like activity of the 20S proteasome, with a value of 50% inhibition concentration IC50 of approximately 1 uM, resulting in a significant accumulation of ubiquitinated p53 and other cellular proteins in whole cells without significantly disrupting the interaction of p53 and murine double minute 2 (mdm2) proteins.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.52 mL 132.62 mL 265.24 mL
0.5 mM 5.3 mL 26.52 mL 53.05 mL
1 mM 2.65 mL 13.26 mL 26.52 mL
5 mM 0.53 mL 2.65 mL 5.3 mL

*The above data is based on the productmolecular weight 377.01. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14922
Actions Inhibitor
M. Wt 377.01
Formula C20H21B2NO5
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 856849-35-9
Synonyms N/A
SMILES B(C1=CC=C(C=C1)C=C2CN(CC(=CC3=CC=C(C=C3)B(O)O)C2=O)C)(O)O

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