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Biological Activity
AM 114, a derivative of boronic chalcone, is a potent small-molecule inhibitor of the proteasome that inhibits the chymotrypsin-like activity of the 20S proteasome, with a value of 50% inhibition concentration IC50 of approximately 1 uM, resulting in a significant accumulation of ubiquitinated p53 and other cellular proteins in whole cells without significantly disrupting the interaction of p53 and murine double minute 2 (mdm2) proteins.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.52 mL | 132.62 mL | 265.24 mL |
| 0.5 mM | 5.3 mL | 26.52 mL | 53.05 mL |
| 1 mM | 2.65 mL | 13.26 mL | 26.52 mL |
| 5 mM | 0.53 mL | 2.65 mL | 5.3 mL |
*The above data is based on the productmolecular weight 377.01. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A14922 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 856849-35-9 |
| Formula | C20H21B2NO5 |
| M. Wt | 377.01 |
| Purity | >98% |
| SMILES | B(C1=CC=C(C=C1)C=C2CN(CC(=CC3=CC=C(C=C3)B(O)O)C2=O)C)(O)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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