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E3 Ligase Ligands

E3 ligase ligands bind ubiquitin ligases such as cereblon and von Hippel-Lindau (VHL) in degrader design. In a degrader, they anchor the ligase end of the molecule. E3 ubiquitin ligases transfer ubiquitin to substrate proteins and mark them for degradation by the proteasome. Thalidomide and its analogs bind cereblon (CRBN), a substrate receptor of a cullin-based E3 ligase complex identified as their direct target in 2010. The category includes cereblon ligands such as thalidomide fluoride and TD-106, and VHL ligands such as VL285 and VH032-cyclopropane-F. These ligands are used to build proteolysis-targeting chimeras (PROTACs) and to study how ligases are recruited to new substrates.

Cat. No.

A80722

CAS No.

2925089-32-1

CRBN ligand-423

CRBN ligand-423 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that plays a critical role in targeted protein degradation. This compound facilitates the recruitment of CRBN to specific target proteins and can be combined with target protein ligands through a linker to create a PROTAC (proteolysis-targeting chimera). Its application in the development of PROTACs provides valuable insights into the modulation of protein levels for therapeutic purposes in various biological research areas.

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Cat. No.

A80723

CAS No.

2925095-25-4

CRBN ligand-256

CRBN ligand-256 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this essential protein. This compound can be utilized in the development of PROTACs by linking it to a target protein ligand through a suitable linker. CRBN ligand-256 is instrumental in studies focused on targeted protein degradation and the modulation of various biological pathways.

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Cat. No.

A80724

CAS No.

2925082-68-2

CRBN ligand-728

CRBN ligand-728 is a ligand that targets the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN proteins. This compound is pivotal in the development of proteolysis-targeting chimeras (PROTACs) by enabling the linkage of target protein ligands through a suitable linker. Its use in research focuses on exploring targeted protein degradation pathways, advancing the understanding of cellular regulation, and uncovering therapeutic strategies in various diseases.

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Cat. No.

A80725

CAS No.

2925072-65-5

CRBN ligand-544

CRBN ligand-544 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized in the development of proteolysis-targeting chimeras (PROTACs) by linking it to a target protein ligand through a suitable linker. Its application in targeted protein degradation studies makes it a valuable tool for researchers investigating ubiquitin-proteasome pathway dynamics and therapeutic interventions in various diseases.

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Cat. No.

A80726

CAS No.

2925086-12-8

CRBN ligand-579

CRBN ligand-579 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to specific protein targets. This compound can be utilized to create proteolysis-targeting chimeras (PROTACs) by linking it to a target protein ligand through a suitable linker. Its capacity to modulate protein degradation pathways makes CRBN ligand-579 valuable for studies involving targeted protein degradation and cellular signaling research.

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Cat. No.

A80727

CAS No.

2925099-84-7

CRBN ligand-554

CRBN ligand-554 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling the targeted recruitment of the cereblon protein. This compound can be conjugated to a ligand of a target protein through a suitable linker to create a PROTAC (proteolysis-targeting chimera). It is applicable in studies focused on targeted protein degradation and the modulation of cellular pathways associated with ubiquitination.

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Cat. No.

A80728

CAS No.

2925070-37-5

CRBN ligand-325

CRBN ligand-325 is a ligand specific for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of the CRBN protein, enabling targeted protein degradation through the formation of PROTACs when linked to a target protein ligand via a suitable linker. It is valuable for applications in ubiquitination research and drug discovery strategies aimed at modulating protein levels within cells.

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Cat. No.

A80729

CAS No.

3084710-09-5

CRBN ligand-186

CRBN ligand-186 is a potent ligand for the CRBN-type E3 ubiquitin ligase, facilitating the construction of PROTAC (proteolysis targeting chimeras). This compound is designed to promote targeted protein degradation by harnessing the ubiquitin-proteasome system. It is instrumental in research applications aimed at investigating protein interactions and elucidating cellular processes involved in metabolic regulation and disease pathogenesis.

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Cat. No.

A80730

CAS No.

2925096-87-1

CRBN ligand-556

CRBN ligand-556 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein for targeted protein degradation. This compound can be utilized in the construction of PROTACs (Proteolysis Targeting Chimeras) by linking to target protein ligands, enabling precise modulation of protein levels. Its application is essential in studying protein homeostasis, cellular signaling pathways, and therapeutic interventions in various diseases.

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Cat. No.

A80731

CAS No.

2407829-93-8

CRBN ligand-680

CRBN ligand-680 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to specific target proteins. This compound can be utilized in the development of PROTACs (Proteolysis Targeting Chimeras) by linking to target protein ligands through a suitable linker. Its application is particularly relevant in the study of targeted protein degradation and the modulation of cellular pathways.

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Cat. No.

A80732

CAS No.

2925093-74-7

CRBN ligand-690

CRBN ligand-690 serves as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. Through the conjugation of CRBN ligand-690 with a target protein ligand via a linker, it enables the formation of PROTACs (proteolysis-targeting chimeras). This reagent is instrumental in studies aimed at targeted protein degradation and the modulation of protein abundance in various biological systems.

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Cat. No.

A80733

CAS No.

2925076-20-4

CRBN ligand-273

CRBN ligand-273 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is designed for use in the development of PROTACs by linking specifically to target protein ligands via a linker, enabling targeted degradation of proteins in cellular contexts. Its applications extend to studies in protein homeostasis and targeted protein degradation mechanisms.

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Cat. No.

A80734

CAS No.

2925100-50-9

CRBN ligand-289

CRBN ligand-289 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. It serves as a critical component in the development of PROTACs (proteolysis-targeting chimeras) by enabling the targeted degradation of specific proteins through the ubiquitin-proteasome pathway. This reagent is essential for exploring cellular mechanisms and therapeutic applications involving targeted protein degradation.

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Cat. No.

A80735

CAS No.

2925092-52-8

CRBN ligand-500

CRBN ligand-500 is a ligand that targets the E3 ubiquitin ligase cereblon (CRBN) to facilitate the recruitment of this protein. It can be conjugated with a target protein ligand using a linker to create a proteolysis-targeting chimera (PROTAC). This compound is instrumental in studies aimed at protein degradation pathways and the modulation of cellular protein levels for therapeutic applications.

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Cat. No.

A80736

CAS No.

2925085-56-7

CRBN ligand-453

CRBN ligand-453 is an E3 ubiquitin ligase ligand that specifically targets cereblon (CRBN) to facilitate its recruitment. This compound is designed to be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimera). It provides a powerful tool for targeted protein degradation studies and is applicable in research aimed at modulating protein levels in various biological contexts.

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Cat. No.

A80737

CAS No.

2925084-34-8

CRBN ligand-369

CRBN ligand-369 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of proteolysis-targeting chimeras (PROTACs). CRBN ligand-369 is instrumental in studies focused on targeted protein degradation and therapeutic applications in various diseases.

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Cat. No.

A80738

CAS No.

2925075-45-0

CRBN ligand-382

CRBN Ligand-382 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized in the development of proteolysis-targeting chimeras (PROTACs) by linking it to a target protein ligand through a suitable linker. Its application in targeted protein degradation research enables the exploration of innovative therapeutic strategies for various diseases.

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Cat. No.

A80739

CAS No.

2760376-01-8

CRBN ligand-208

CRBN ligand-208 is a small-molecule ligand targeting the E3 ubiquitin ligase cereblon (CRBN). It is designed to facilitate the recruitment of CRBN to target proteins, enabling targeted protein degradation through PROTAC technology. This compound is applicable in research focusing on protein regulation and cellular signaling pathways, providing a valuable tool for drug discovery and development.

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Cat. No.

A80740

CAS No.

2154343-20-9

CRBN ligand-753

CRBN ligand-753 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. By attaching this compound to a target protein ligand through a linker, it can be utilized in the development of PROTACs (proteolysis-targeting chimeras). This compound is particularly valuable in research focused on targeted protein degradation and investigating the function of specific proteins involved in various biological processes.

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Cat. No.

A80741

CAS No.

3031608-38-2

CRBN ligand-686

CRBN ligand-686 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is designed to be conjugated with a target protein ligand through a linker, enabling the formation of a proteolysis-targeting chimera (PROTAC). It has potential applications in targeted protein degradation studies and investigating protein homeostasis in various biological contexts.

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Cat. No.

A80742

CAS No.

2925100-18-9

CRBN ligand-478

CRBN ligand-478 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC (Proteolysis Targeting Chimeras). Its utility in controlling protein degradation makes it a valuable reagent for research applications in targeted protein modulation and therapeutic development.

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Cat. No.

A80743

CAS No.

3031607-36-7

CRBN ligand-228

CRBN ligand-228 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein for targeted protein degradation. It can be conjugated with a target protein ligand through a linker to generate a PROTAC (proteolysis-targeting chimera). This compound is instrumental in studies aimed at exploring the degradation of specific proteins and developing novel therapeutic strategies in cancer and other diseases.

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Cat. No.

A80744

CAS No.

2803445-69-2

Thalidomide-5-Br,6-F

Thalidomide-5-Br,6-F is a Thalidomide analogue functioning as an E3 ligase activator, promoting the ubiquitination of target proteins for proteolytic degradation. This compound enhances cellular pathways by modulating protein turnover, making it valuable in studies related to protein homeostasis and targeted degradation. Its unique structural features allow for potential further derivatization through substitution at the fluorine or bromine positions, offering avenues for the development of novel reagents.

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$245.00

50 mg

$355.00

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Cat. No.

A80745

CAS No.

2925102-22-1

CRBN ligand-620

CRBN ligand-620 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC, which enhances targeted protein degradation. CRBN ligand-620 is relevant for research applications in protein modulation and therapeutic development, particularly in the study of protein homeostasis.

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Cat. No.

A80746

CAS No.

2925102-45-8

CRBN ligand-304

CRBN ligand-304 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated with a target protein ligand through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimera). CRBN ligand-304 is instrumental in studying protein degradation pathways and the development of targeted therapeutics in cancer research and other therapeutic areas.

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