Catalog No.
Product Name
Application
Product Information
Citations
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Ligand for E3 Ligase
CRBN ligand-352 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to target protein ligands through a suitable linker, enabling the development of PROTACs (proteolysis-targeting chimeras). Its application in targeted protein degradation research provides a valuable tool for studying protein function and modulation in cellular pathways. -
Ligand for E3 Ligase
CRBN ligand-662 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker to generate a PROTAC (proteolysis-targeting chimera). Its utility in targeted protein degradation research makes it a valuable tool for studying cellular protein regulation and potential therapeutic applications. -
Ligand for E3 Ligase
CRBN ligand-627 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC (proteolysis-targeting chimera), enabling selective degradation of target proteins. It serves as a valuable tool in chemical biology and therapeutic research, particularly in the development of targeted protein degradation strategies. -
Ligand for E3 Ligase
CRBN ligand-440 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this protein within cellular systems. Its design allows for conjugation with target protein ligands through a linker, enabling the synthesis of proteolysis-targeting chimeras (PROTACs). This compound is valuable for studying protein degradation pathways and exploring novel therapeutic strategies in targeted protein degradation research. -
Ligand for E3 Ligase
CRBN ligand-543 targets the E3 ubiquitin ligase cereblon (CRBN) and is utilized for its ability to recruit the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a Proteolysis Targeting Chimera (PROTAC), facilitating targeted protein degradation. Research applications include the investigation of protein modulation and therapeutic strategies in various diseases. -
Ligand for E3 Ligase
CRBN ligand-717 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to generate a PROTAC (proteolysis-targeting chimera), thereby enabling targeted protein degradation. It is valuable in research applications focused on protein regulation and degradation pathways. -
Ligand for E3 Ligase
Hydrouracil-4-benzazimide-7-NH2 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand using a linker, enabling the construction of proteolysis targeting chimeras (PROTACs). It is of particular interest in pharmacological research for its potential to modulate protein degradation pathways. -
Ligand for E3 Ligase
Desamino lenalidomide-5-acetonitrile is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein in targeted protein degradation. This compound can be conjugated to a target protein ligand using a linker to create a PROTAC, enabling the selective degradation of specific proteins. Its applications in chemical biology and therapeutics make it a valuable tool for studying protein regulation and developing innovative treatments. -
Ligand for E3 Ligase
CRBN ligand-345 is an E3 ubiquitin ligase ligand that specifically targets cereblon (CRBN). This compound is utilized to facilitate the recruitment of the CRBN protein, thereby enabling targeted protein degradation through the formation of PROTACs when linked to a target protein ligand via a suitable linker. Its application is significant in investigating the dynamics of protein turnover and elucidating cellular processes involving ubiquitination. -
Ligand for E3 Ligase
CRBN ligand-231 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized to create a PROTAC (Proteolysis Targeting Chimeras) by linking it to a target protein ligand through a suitable linker. CRBN ligand-231 is instrumental in research applications focused on targeted protein degradation and the study of ubiquitin-proteasome pathway mechanisms. -
Ligand for E3 Ligase
CRBN ligand-461 is an E3 ubiquitin ligase ligand that specifically targets cereblon (CRBN). It facilitates the recruitment of the CRBN protein and can be utilized to form a PROTAC by linking to a target protein ligand through a suitable linker. This compound is instrumental in studies involving targeted protein degradation and has potential applications in drug discovery and development. -
Ligand for E3 Ligase
CRBN ligand-303 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. Its ability to be conjugated with a target protein ligand through a linker allows for the development of PROTACs, enabling targeted protein degradation. This compound is instrumental in studying protein regulation and exploring therapeutic applications in cancer and other diseases. -
Ligand for E3 Ligase
CRBN ligand-563 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be utilized in the design of PROTACs (proteolysis-targeting chimeras) by linking it with target protein ligands via a suitable linker. Its applications include targeted protein degradation studies and exploring novel therapeutic strategies in various diseases. -
Ligand for E3 Ligase
CRBN ligand-587 is a ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of CRBN to target proteins, allowing for the targeted degradation of these proteins through the PROTAC (Proteolysis Targeting Chimeras) pathway. CRBN ligand-587 is instrumental in research applications focusing on protein modulation and targeted protein degradation strategies. -
Ligand for E3 Ligase
CRBN ligand-201 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized to link with target protein ligands through a suitable linker, enabling the formation of proteolysis-targeting chimeras (PROTACs). Its application is primarily in the fields of targeted protein degradation and drug discovery, offering insights into cellular regulation and therapeutic interventions. -
Ligand for E3 Ligase
CRBN ligand-635 is an E3 ubiquitin ligase ligand specifically designed to interact with cereblon (CRBN). This compound facilitates the recruitment of the CRBN protein, enabling targeted protein degradation by forming a PROTAC when conjugated with a target protein ligand through a linker. The biological activity of CRBN ligand-635 makes it valuable for research applications focused on protein homeostasis and novel therapeutic strategies in cellular and molecular biology. -
Ligand for E3 Ligase
CRBN ligand-713 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein for targeted protein degradation. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). CRBN ligand-713 serves as a valuable tool in chemical biology for studying protein regulation and potential therapeutic applications in targeted degradation strategies. -
Ligand for E3 Ligase
CRBN ligand-373 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein to target proteins. This compound is designed to be covalently linked to target protein ligands through a linker, enabling the formation of proteolysis-targeting chimeras (PROTACs). Its application in targeted protein degradation research offers valuable insights into cellular processes and therapeutic interventions. -
Ligand for E3 Ligase
CRBN ligand-633 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of CRBN to target proteins, enabling the formation of proteolysis-targeting chimeras (PROTACs) when linked to specific target protein ligands through a suitable linker. This compound is instrumental in modulating protein degradation pathways for research in drug development and targeted cancer therapies. -
Ligand for E3 Ligase
CRBN ligand-580 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC (Proteolysis Targeting Chimeras), enabling targeted protein degradation. Its applications include insights into protein regulation mechanisms and drug discovery processes. -
Ligand for E3 Ligase
CRBN ligand-296 is a ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of CRBN to target proteins, enabling targeted protein degradation through PROTAC (Proteolysis Targeting Chimeras) technology. This compound is valuable for research applications focused on ubiquitin-mediated proteolysis and the development of novel therapeutic strategies for various diseases. -
Ligand for E3 Ligase
CRBN ligand-393 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. It can be effectively linked to target protein ligands through a suitable linker to create a PROTAC, enabling targeted protein degradation. This compound is valuable for research applications focused on therapeutic interventions in cellular processes mediated by protein homeostasis. -
Ligand for E3 Ligase
CRBN ligand-555 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the synthesis of a PROTAC (proteolysis-targeting chimera). CRBN ligand-555 serves as a valuable tool in studies of targeted protein degradation and has applications in the development of novel therapeutic strategies for various diseases. -
Ligands for E3 Ligase
(S,S,S)-AHPC-Me is a ligand for E3 ligases, playing a crucial role in targeted protein degradation pathways. This compound facilitates the synthesis of PROTACs, specifically the (4S)-PROTAC SOS1 degrader-1 diTFA. Its efficacy in modulating E3 ligase activity makes it valuable for research applications in cellular signaling and therapeutic development. -
Ligand for E3 Ligase
Thalidomide-4-OH-(S)-CH3 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of cereblon to target proteins, enabling the formation of PROTACs (proteolysis-targeting chimeras) when linked to target protein ligands via appropriate linkers. Its ability to modulate protein degradation pathways makes it valuable for research applications in targeted protein degradation and therapeutic development. -
Ligand for E3 Ligase
CRBN ligand-528 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN). It serves as a molecular tool to recruit the CRBN protein, facilitating targeted protein degradation when conjugated to a target protein ligand through a suitable linker. This compound is essential for research applications focused on understanding ubiquitin-mediated proteolysis and developing PROTAC (Proteolysis Targeting Chimera) strategies for therapeutic intervention. -
Ligand for E3 Ligase
CRBN ligand-413 is an E3 ubiquitin ligase ligand that specifically targets cereblon (CRBN). This compound facilitates the recruitment of the CRBN protein and can be utilized in the development of PROTACs by linking it to a target protein ligand through a suitable linker. Its applications are significant in studying targeted protein degradation and the modulation of protein levels within cellular contexts. -
Ligand for E3 Ligase
CRBN ligand-264 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling targeted recruitment of the CRBN protein. This compound is instrumental in the development of proteolysis-targeting chimeras (PROTACs) by linking to target protein ligands through a suitable linker, facilitating selective degradation of proteins in cellular environments. Its application in research may enhance studies related to protein regulation and therapeutic interventions targeting protein homeostasis. -
Ligand for E3 Ligase
CRBN ligand-271 is a targeted ligand for the E3 ubiquitin ligase cereblon (CRBN). It functions by recruiting the cereblon protein, enabling the formation of PROTACs (proteolysis-targeting chimeras) when linked to a specific target protein ligand through a suitable linker. This compound is valuable for studies involving targeted protein degradation and cellular regulation, assisting researchers in exploring novel therapeutic approaches in cancer and other diseases. -
Ligand for E3 Ligase
CRBN ligand-659 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a suitable linker, enabling the development of PROTACs (proteolysis-targeting chimeras). Its utility in research lies in targeted protein degradation and the modulation of cellular pathways, making it a valuable tool for studying protein function and therapeutic interventions. -
Ligand for E3 Ligase
CRBN ligand-634 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of CRBN to target proteins, making it a vital component in the design of proteolysis-targeting chimeras (PROTACs). This reagent is suitable for studies aimed at investigating targeted protein degradation and its therapeutic potential in various diseases. -
Ligand for E3 Ligase
CRBN ligand-234 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to specific target proteins. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a proteolysis-targeting chimera (PROTAC). CRBN ligand-234 serves as a valuable tool in studies of targeted protein degradation and the therapeutic potential of PROTACs in various biological contexts. -
Ligand for E3 Ligase
CRBN ligand-566 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a Proteolysis Targeting Chimeras (PROTACs). CRBN ligand-566 is valuable for research focused on targeted protein degradation and the modulation of cellular pathways involving E3 ligases. -
Ligands for E3 Ligase
E3 Ligase Ligand 30 is a potent ligand for E3 ubiquitin ligases, facilitating the modulation of ubiquitination processes within cellular systems. Its primary mechanism involves binding to the E3 ligase, enhancing substrate recognition and specificity. This compound exhibits significant potential for studying protein degradation pathways and exploring targeted protein modulation in various research applications, including cancer biology and therapeutic development. -
Ligand for E3 Ligase
CRBN ligand-491 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to specific target proteins. This compound serves as a crucial component in the design of PROTACs (proteolysis-targeting chimeras), enabling targeted degradation of proteins in cellular systems. Its application is significant in drug discovery and the study of ubiquitin-mediated proteolysis. -
Ligand for E3 Ligase
CRBN ligand-581 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound effectively recruits the cereblon protein, facilitating targeted protein degradation through the formation of PROTACs (Proteolysis Targeting Chimeras). Its utility in research extends to the development of novel therapeutic strategies and the study of ubiquitin-mediated degradation pathways. -
Ligand for E3 Ligase
CRBN ligand-235 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated with a target protein ligand through a linker to create a PROTAC (Proteolysis Targeting Chimera). CRBN ligand-235 is valuable for research in targeted protein degradation and elucidation of ubiquitin-proteasome system mechanisms. -
Ligand for E3 Ligase
CRBN ligand-320 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to specific target proteins. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC that promotes the ubiquitination and subsequent degradation of the target protein. CRBN ligand-320 serves as a valuable tool for research in targeted protein degradation and cellular protein regulation. -
Ligand for E3 Ligase
CRBN ligand-286 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound enables the development of Proteolysis Targeting Chimeras (PROTACs) by linking to a target protein ligand through a suitable linker. CRBN ligand-286 is essential for studies focused on targeted protein degradation and ubiquitin-mediated proteolysis, providing valuable insights into cellular regulation and therapeutic interventions. -
Ligand for E3 Ligase
CRBN ligand-274 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling targeted protein degradation through the recruitment of CRBN to specific substrate proteins. It serves as a critical component in the design of PROTAC (proteolysis-targeting chimera) molecules, facilitating the ubiquitination and subsequent degradation of the target protein. This reagent is valuable for researchers investigating protein regulation and developing therapeutic strategies in oncology and other disease areas. -
Ligand for E3 Ligase
CRBN ligand-417 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of CRBN, enabling targeted protein degradation through the PROTAC (Proteolysis Targeting Chimeras) approach. This compound is valuable in studying protein regulation and degradation mechanisms, making it a useful tool in cancer research and drug discovery applications. -
Ligand for E3 Ligase
CRBN ligand-608 is a highly selective ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling the targeted recruitment of the CRBN protein. This compound can be effectively used in the synthesis of PROTACs (Proteolysis Targeting Chimeras) by linking it to target protein ligands through a suitable linker. Its application in protein degradation research provides a valuable tool for studying disease mechanisms and therapeutic interventions. -
Ligand for E3 Ligase
CRBN ligand-609 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of cereblon for targeted protein degradation. This compound can be conjugated to a target protein ligand through a linker, enabling the development of Proteolysis Targeting Chimeras (PROTACs). CRBN ligand-609 is valuable for research applications in the study of targeted therapeutics and protein homeostasis. -
Thalidomide Analog
Thalidomide-pinacolborane is a Thalidomide analogue that incorporates a boronic pinacol ester (Bpin group) and serves as an activator for E3 ligases. This compound plays a crucial role in ubiquitination, facilitating the targeted degradation of proteins through proteolytic pathways. Its applications in chemical biology include studies on protein regulation and modulation of cellular signaling processes, making it a valuable tool in research focused on proteostasis and therapeutic interventions. -
Ligand for E3 Ligase
CRBN ligand-262 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. It serves as a crucial component in the development of Proteolysis Targeting Chimeras (PROTACs) when conjugated to target protein ligands through a linker. This compound is valuable for research applications focused on targeted protein degradation and modulation of cellular protein levels. -
Ligand for E3 Ligase
CRBN ligand-596 serves as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a proteolysis-targeting chimera (PROTAC). CRBN ligand-596 is valuable for research applications focused on targeted protein degradation and the study of ubiquitin-mediated processes. -
Ligand for E3 Ligase
CRBN ligand-722 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to specific target proteins. This compound is designed for use in PROTAC (Proteolysis Targeting Chimeras) applications, enabling the effective degradation of target proteins through ubiquitin-proteasome pathways. Its versatility makes it a valuable tool for studying protein turnover and targeted protein modulation in various biological contexts. -
Ligand for E3 Ligase
CRBN ligand-711 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). CRBN ligand-711 is valuable in research applications focusing on targeted protein degradation and therapeutic strategies involving the modulation of cellular protein levels. -
Ligand for E3 Ligase
CRBN ligand-525 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to target protein ligands through a suitable linker, enabling the formation of Proteolysis Targeting Chimeras (PROTACs). CRBN ligand-525 is instrumental in studies focused on targeted protein degradation and the modulation of cellular pathways. -
Ligand for E3 Ligase
CRBN ligand-263 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized in the development of PROTACs by linking it with a target protein ligand through a suitable linker, thereby enabling targeted degradation of specific proteins. It serves as a valuable tool in biochemistry and cell biology research for studies focused on proteolysis and protein regulation.
