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E3 ligase ligands bind ubiquitin ligases such as cereblon and von Hippel-Lindau (VHL) in degrader design. In a degrader, they anchor the ligase end of the molecule. E3 ubiquitin ligases transfer ubiquitin to substrate proteins and mark them for degradation by the proteasome. Thalidomide and its analogs bind cereblon (CRBN), a substrate receptor of a cullin-based E3 ligase complex identified as their direct target in 2010. The category includes cereblon ligands such as thalidomide fluoride and TD-106, and VHL ligands such as VL285 and VH032-cyclopropane-F. These ligands are used to build proteolysis-targeting chimeras (PROTACs) and to study how ligases are recruited to new substrates.
CRBN ligand-457 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound serves as a valuable tool for the development of PROTACs by linking CRBN to target protein ligands through a suitable linker. Its utility in targeted protein degradation research makes it an essential reagent for studies in drug discovery and cellular biology.
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5-Bromomethylthalidomide is an E3 ligase activator that facilitates protein ubiquitination, thereby influencing protein stability and degradation pathways. This compound serves as a key tool in research focused on targeted protein degradation and cellular regulation mechanisms. Its potential for further derivatization through bromide substitution enhances its utility in chemical biology and therapeutic research.
CRBN ligand-658 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN in cellular systems. It is designed for the development of proteolysis-targeting chimeras (PROTACs) by linking to target protein ligands via a suitable linker. This compound is useful in investigating ubiquitin-proteasome pathway mechanisms and advancing targeted protein degradation research.
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CRBN ligand-513 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of the CRBN protein. This compound can be utilized in the development of proteolysis-targeting chimeras (PROTACs) by linking it to a target protein ligand through a suitable linker. Its primary application lies in targeted protein degradation studies, contributing to research on cellular regulation and therapeutic development.
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(R,S,R)-AHPC-NHBoc is a ligand for the E3 ubiquitin ligase VHL that facilitates the recruitment of the VHL protein. This compound can be utilized to construct PROTACs by linking it to a target protein ligand through a suitable linker. Its ability to modulate protein degradation pathways makes it a valuable tool for research in targeted protein degradation and related therapeutic applications.
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CRBN ligand-763 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker to generate a PROTAC (proteolysis-targeting chimera), enabling targeted protein degradation. It serves as a valuable tool in drug discovery and therapeutic research aimed at modulating protein levels within cells.
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CRBN ligand-236 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of CRBN to target proteins, enabling the development of proteolysis-targeting chimeras (PROTACs). CRBN ligand-236 serves as a valuable tool for studying protein degradation pathways and exploring new therapeutic strategies in cellular biology and drug discovery.
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CRBN ligand-628 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to effectively recruit the CRBN protein. It can be utilized to conjugate with a target protein ligand through a linker, facilitating the formation of PROTACs (proteolysis-targeting chimeras). This compound serves as a valuable tool in targeted protein degradation research, enabling the investigation of protein function and regulation in various biological contexts.
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CRBN ligand-521 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this essential protein. It can be conjugated to a target protein ligand through a linker to create a PROTAC, enabling targeted protein degradation. This reagent is valuable for research applications in drug discovery and development, particularly in the study of protein homeostasis and therapeutic intervention.
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CRBN ligand-358 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized in the development of PROTACs by linking it to a target protein ligand through a suitable linker, enabling targeted protein degradation. Its applications in chemical biology research include studying protein homeostasis and dissecting cellular pathways.
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CRBN ligand-671 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of CRBN to target proteins, enabling the development of targeted protein degradation strategies through the formation of PROTACs (Proteolysis Targeting Chimeras). CRBN ligand-671 is instrumental in research applications focusing on protein regulation and cellular signaling pathways.
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CRBN ligand-439 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN for targeted protein degradation. This compound can be conjugated to a target protein ligand through a linker to form a PROTAC, enabling the modulation of protein levels and function in various biological contexts. It serves as a valuable tool for researchers investigating targeted protein degradation pathways and the role of CRBN in cellular processes.
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CRBN ligand-657 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized in the development of PROTACs by linking it to a target protein ligand through a suitable linker. CRBN ligand-657 is valuable for investigating the mechanisms of targeted protein degradation and exploring therapeutic possibilities in various diseases.
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CRBN ligand-343 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), functioning primarily to recruit the CRBN protein. This compound can be conjugated to target protein ligands through a linker, facilitating the formation of PROTACs (proteolysis-targeting chimeras). It is valuable in research applications focused on targeted protein degradation and modulation of cellular protein levels, contributing to novel therapeutic strategies.
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CRBN ligand-536 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized in the design of PROTACs by linking it to a specific target protein ligand through a suitable linker, enabling targeted protein degradation. CRBN ligand-536 is instrumental for research applications in the fields of targeted therapy and proteomics.
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CRBN ligand-701 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to target protein ligands through a linker to create PROTAC molecules, enabling targeted protein degradation. Its applications extend to research in targeted therapy and the study of protein regulation within cellular systems.
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CRBN ligand-424 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is designed for use in PROTAC (Proteolysis Targeting Chimeras) development by linking to target protein ligands through a suitable linker. Its capacity to modulate protein degradation pathways makes it valuable for research in targeted protein degradation and therapeutic development.
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CRBN ligand-683 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is particularly valuable for the development of PROTAC (Proteolysis Targeting Chimeras) by linking to target protein ligands through a suitable linker. CRBN ligand-683 is instrumental in studies of targeted protein degradation and may be harnessed in various research applications related to proteostasis and disease modulation.
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CRBN ligand-510 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC. It plays a significant role in targeted protein degradation research, providing valuable insights for drug development and therapeutic interventions.
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CRBN ligand-696 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It is designed to facilitate the recruitment of cereblon to specific target proteins. By linking CRBN ligand-696 to a target protein ligand through a suitable linker, it enables the formation of proteolysis-targeting chimeras (PROTACs), which are valuable tools for targeted protein degradation studies and therapeutic applications in cancer and other diseases.
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CRBN ligand-308 is an E3 ubiquitin ligase cereblon (CRBN) ligand that facilitates the recruitment of the cereblon protein. This compound can be utilized to chemically link to a target protein ligand through a suitable linker, enabling the development of proteolysis-targeting chimeras (PROTACs). Its ability to modulate protein degradation pathways makes it a valuable tool for studying protein turnover and the therapeutic potential of targeted protein degradation in various biological contexts.
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Thalidomide-SH is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of cereblon to target proteins, enabling targeted protein degradation through PROTAC technology. Thalidomide-SH serves as a versatile tool in chemical biology and drug discovery, offering potential applications in studying protein regulation and developing new therapeutic strategies.
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CRBN ligand-412 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of CRBN to target proteins, enabling the formation of proteolysis-targeting chimeras (PROTACs). This compound is essential for studies focused on targeted protein degradation and therapeutic applications in cancer research and other diseases.
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CRBN ligand-578 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. It can be conjugated to target protein ligands through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimera). This compound is valuable for studies in targeted protein degradation and cellular protein modulation, making it useful in therapeutic research and drug development.
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CRBN ligand-455 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the cereblon protein. This compound can be utilized to create proteolysis-targeting chimeras (PROTACs) by linking to a target protein ligand through a suitable linker, enabling targeted protein degradation. It serves as a valuable tool for exploring protein function and regulation, particularly in the context of drug discovery and therapeutic development.
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