E3 Ligase Ligands

Cat. No.

A80997

CAS No.

2789680-40-4

CRBN ligand-392

CRBN ligand-392 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of CRBN to specific target proteins. This compound is utilized in the development of proteolysis-targeting chimeras (PROTACs) when covalently linked to a target protein ligand through a suitable linker, enabling selective degradation of the target protein. Research applications include targeted protein degradation studies and exploring novel therapeutic approaches in cellular biology.

Cat. No.

A80998

CAS No.

2925069-56-1

CRBN ligand-391

CRBN ligand-391 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of proteolysis-targeting chimeras (PROTACs). It plays a significant role in targeted protein degradation research and drug discovery applications, contributing to advancements in therapeutic strategies for various diseases.

Cat. No.

A80999

CAS No.

2925098-95-7

CRBN ligand-626

CRBN ligand-626 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This molecule can be conjugated to a target protein ligand through a linker, enabling the formation of a proteolysis-targeting chimera (PROTAC). Researchers can utilize CRBN ligand-626 in studies exploring targeted protein degradation and the modulation of various biological pathways.

Cat. No.

A81000

CAS No.

2740657-30-9

Thalidomide-4-Br,7-F

Thalidomide-4-Br,7-F is an E3 ligase activator, containing both bromine and fluorine substituents. E3 ligases play a crucial role in the ubiquitin-proteasome system by tagging proteins for degradation, thereby regulating various cellular processes. This compound's halogen functional groups allow for potential further derivatization, making it a valuable tool for research in protein degradation pathways and targeted protein modulation. Its application extends to studies involving cancer biology, protein regulation, and therapeutic development.

Cat. No.

A81001

CAS No.

2925100-09-8

CRBN ligand-757

CRBN ligand-757 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a proteolysis-targeting chimeric molecule (PROTAC). CRBN ligand-757 serves as a valuable tool in chemical biology and therapeutic development, particularly in studies focused on targeted protein degradation.

Cat. No.

A81002

CAS No.

2925097-88-5

CRBN ligand-535

CRBN ligand-535 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is suitable for use in the development of PROTACs, enabling targeted protein degradation through an innovative bifunctional mechanism. Its ability to bridge ligands to target proteins makes it valuable for researchers studying ubiquitin-proteasome system modulation and therapeutic protein degradation strategies.

Cat. No.

A81003

CAS No.

2438243-28-6

Desamino lenalidomide-4-F-7-Br

Desamino lenalidomide-4-F-7-Br is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of CRBN, enabling targeted protein degradation through the formation of PROTACs when linked with a target protein ligand. Its application in research includes investigating the role of CRBN in various cellular processes and potential therapeutic strategies in cancer and other diseases.

Cat. No.

A81004

CAS No.

2925069-79-8

CRBN ligand-443

CRBN ligand-443 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be utilized in the development of PROTAC (Proteolysis Targeting Chimeras) by linking it to a target protein ligand through a suitable linker. Its application in targeted protein degradation supports innovative research in therapeutic development and cellular regulation.

Cat. No.

A81005

CAS No.

2357110-15-5

Thalidomide-Piperazine-PEG2-NH2 hydrochloride

Thalidomide-Piperazine-PEG2-NH2 hydrochloride is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be utilized in the development of PROTACs by linking it to a target protein ligand via a suitable linker, thus advancing research in targeted protein degradation and related therapeutic applications. Its ability to modulate protein levels makes it a valuable tool in cellular and molecular biology studies.

Cat. No.

A81006

CAS No.

2925097-66-9

CRBN ligand-484

CRBN ligand-484 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to target protein ligands through a linker, enabling the development of PROTACs that promote targeted protein degradation. Its utility in research includes exploring the mechanisms of ubiquitin-proteasome system modulation and protein homeostasis in cellular contexts.

Cat. No.

A81007

CAS No.

1797406-78-0

(S,S,S)-AHPC

Synonyms: (S,S,S)-VH032-NH2

(S,S,S)-AHPC is a specific ligand for E3 ligases, serving as a crucial component in targeted protein degradation applications. It is utilized for the synthesis of PROTAC AH081, which can facilitate the degradation of specific proteins within cells. This compound is an important tool in research focused on understanding protein interactions and developing novel therapeutic strategies through modulation of E3 ligase activity.

Cat. No.

A81008

CAS No.

2925096-35-9

CRBN ligand-488

CRBN ligand-488 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN for targeted protein degradation. This compound can be conjugated with a target protein ligand through a linker to create a proteolysis-targeting chimera (PROTAC). Its utility in targeted protein elimination makes it an important tool for investigating cellular processes and therapeutic applications in cancer and other diseases.

Cat. No.

A81009

CAS No.

2925087-92-7

CRBN ligand-741

CRBN ligand-741 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of cereblon, enabling the formation of proteolysis-targeting chimeras (PROTACs) when linked to a target protein ligand via a suitable linker. This compound is valuable for studies in targeted protein degradation, offering potential applications in drug development and cancer research.

Cat. No.

A81010

CAS No.

2925095-97-0

CRBN ligand-307

CRBN ligand-307 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of PROTACs (proteolysis-targeting chimeras). CRBN ligand-307 is valuable in research applications focused on targeted protein degradation and the modulation of cellular protein levels, making it an essential tool for studies in drug discovery and therapeutic development.

Cat. No.

A81011

CAS No.

3065496-78-5

CRBN ligand-45

CRBN ligand-45 functions as a ligand for the CRBN-type E3 ubiquitin ligase, facilitating targeted protein degradation through the proteolysis-targeting chimera (PROTAC) technology. This compound is essential for research applications focused on investigating ubiquitination pathways and developing novel therapeutic strategies that harness the ubiquitin-proteasome system. Its ability to selectively engage E3 ligases makes it a valuable tool in the study of cellular protein homeostasis and degradation mechanisms.

Cat. No.

A81012

CAS No.

2825006-38-8

Thalidomide-5-methanol

Thalidomide-5-methanol is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound has applications in the development of proteolysis-targeting chimeras (PROTACs) by enabling the linkage to target protein ligands via a suitable linker. Thalidomide-5-methanol is utilized in research exploring targeted protein degradation and the therapeutic potential of modulating CRBN activity.

Cat. No.

A81013

CAS No.

2573307-29-4

CRBN ligand-796

CRBN ligand-796 serves as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound is designed for use in PROTAC (PROteolysis TArgeting Chimeras) technology, allowing for the targeted degradation of proteins by linking to specific target protein ligands through a suitable linker. Its role in modulating protein degradation pathways makes it a valuable tool for research in targeted therapeutics and cellular signaling studies.

Cat. No.

A81014

CAS No.

2925081-29-2

CRBN ligand-589

CRBN ligand-589 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated with a target protein ligand through a linker to create a proteolysis-targeting chimeric molecule (PROTAC). Its applications in chemical biology include the modulation of protein degradation pathways and the investigation of targeted protein therapy mechanisms.

Cat. No.

A81015

CAS No.

2933136-83-3

CRBN ligand-229

CRBN ligand-229 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be successfully linked to a target protein ligand through a linker to create a PROTAC (proteolysis-targeting chimera). Research applications of CRBN ligand-229 include targeted protein degradation and the study of ubiquitin-mediated proteostasis pathways.

Cat. No.

A81016

CAS No.

2357111-30-7

CRBN ligand-858

CRBN ligand-858 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is instrumental in the development of proteolysis-targeting chimeras (PROTACs) when linked to a target protein ligand through an appropriate linker. Its applications extend to advancing research in targeted protein degradation and exploring novel therapeutic strategies.

Cat. No.

A81017

CAS No.

2925069-71-0

CRBN ligand-644

CRBN ligand-644 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this protein to target substrates. It can be conjugated to target protein ligands through a linker to generate a PROTAC (proteolysis-targeting chimera), enabling targeted protein degradation. This reagent is valuable for research in protein dynamics and therapeutic development through modulation of the ubiquitin-proteasome system.

Cat. No.

A81018

CAS No.

2925096-16-6

CRBN ligand-718

CRBN ligand-718 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein in cellular assays. This compound serves as a valuable tool for the development of proteolysis-targeting chimeras (PROTACs) by linking to a target protein ligand via a linker. Its applications include studying protein degradation pathways and creating innovative therapeutic strategies in targeted protein degradation research.

Cat. No.

A81019

CAS No.

2925092-24-4

CRBN ligand-295

CRBN ligand-295 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of CRBN to target proteins, enabling targeted protein degradation through the formation of proteolysis-targeting chimeras (PROTACs). It is ideal for research applications in drug discovery and development, particularly in the study of protein homeostasis and cellular regulation.

Cat. No.

A81020

CAS No.

2925100-23-6

CRBN ligand-290

CRBN ligand-290 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound serves as a building block for the development of PROTACs (Proteolysis Targeting Chimeras) by enabling the conjugation of CRBN with a target protein ligand through a suitable linker. Its application is significant in studies involving targeted protein degradation, offering insights into therapeutic interventions and functional protein regulation in various biological contexts.

Cat. No.

A81021

CAS No.

1010913-79-7

SJ6145

SJ6145 is a potent ligand for KLHDC2, exhibiting a dissociation constant (Kd) of 16.9 μM as determined by surface plasmon resonance (SPR) assays. This compound demonstrates an IC50 value of 42 μM in inhibiting KLHDC2's binding to a di-Gly degron peptide, highlighting its potential role in investigating KLHDC2-mediated cellular processes. SJ6145 can be utilized in research applications focused on protein degradation and regulatory mechanisms in cellular homeostasis.