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E3 Ligase Ligands

E3 ligase ligands bind ubiquitin ligases such as cereblon and von Hippel-Lindau (VHL) in degrader design. In a degrader, they anchor the ligase end of the molecule. E3 ubiquitin ligases transfer ubiquitin to substrate proteins and mark them for degradation by the proteasome. Thalidomide and its analogs bind cereblon (CRBN), a substrate receptor of a cullin-based E3 ligase complex identified as their direct target in 2010. The category includes cereblon ligands such as thalidomide fluoride and TD-106, and VHL ligands such as VL285 and VH032-cyclopropane-F. These ligands are used to build proteolysis-targeting chimeras (PROTACs) and to study how ligases are recruited to new substrates.

Cat. No.

A81222

CAS No.

2740657-28-5

Thalidomide-4-F,5-Br

Thalidomide-4-F,5-Br is a Thalidomide analogue designed to enhance E3 ligase recruitment for the ubiquitination and subsequent degradation of target proteins. This compound exhibits potential biological activity in modulating protein turnover, making it a valuable tool in diverse research applications, including cancer studies and the investigation of cellular signaling pathways. Furthermore, the presence of fluorine and bromine allows for further derivatization, enabling the exploration of new molecular properties and activities.

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$170.00

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Cat. No.

A81223

CAS No.

2925075-14-3

CRBN ligand-383

CRBN ligand-383 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to specific target protein ligands using a linker to generate PROTAC molecules. Its primary applications include targeted protein degradation and investigation of CRBN-mediated pathways in cellular processes.

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Cat. No.

A81224

CAS No.

2766179-36-4

CRBN ligand-205

CRBN ligand-205 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. It is designed for use in the development of PROTACs, allowing for targeted degradation of specific proteins through the formation of a linkage between CRBN and a target protein ligand. This compound is essential for research in protein regulation and therapeutic applications in targeted protein degradation strategies.

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Cat. No.

A81225

CAS No.

2925072-66-6

CRBN ligand-731

CRBN ligand-731 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this critical protein. This compound can be conjugated to a target protein ligand through a linker, enabling the development of proteolysis-targeting chimeras (PROTACs). CRBN ligand-731 is instrumental in studies focused on targeted protein degradation and offers valuable insights into cellular protein regulation.

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Cat. No.

A81226

CAS No.

2925100-36-1

CRBN ligand-710

CRBN ligand-710 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), utilized to facilitate the recruitment of CRBN in targeted protein degradation. It can be conjugated to a specific target protein ligand through a linker, enabling the formation of PROTACs (proteolysis-targeting chimeras). This compound is instrumental in studies focusing on protein regulation and degradation pathways, thereby advancing research in cancer therapeutics and other diseases related to protein homeostasis.

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Cat. No.

A81227

CAS No.

2925078-81-3

CRBN ligand-745

CRBN ligand-745 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this protein for targeted protein degradation. By connecting CRBN ligand-745 to a target protein ligand through a linker, it serves as an essential component in the design of PROTACs (proteolysis-targeting chimeras). This functionality enables researchers to explore novel therapeutic strategies that manipulate protein levels within cells, advancing the understanding of disease mechanisms and drug development.

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Cat. No.

A81228

CAS No.

2925082-34-2

CRBN ligand-297

CRBN ligand-297 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a suitable linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimera). CRBN ligand-297 is crucial for studies involving targeted protein degradation and therapeutic development in various diseases, including cancer.

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Cat. No.

A81229

CAS No.

2924122-72-3

Desamino lenalidomide-5-F-4-CH2NH2 hydrochloride

Desamino lenalidomide-5-F-4-CH2NH2 hydrochloride is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC (proteolysis-targeting chimera), enabling targeted proteasomal degradation of specific proteins. Its application in protein degradation studies holds significant potential for advancing therapeutic strategies in various disease models.

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Cat. No.

A81230

CAS No.

2925087-53-0

CRBN ligand-435

CRBN ligand-435 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound serves as a key component in the development of PROTACs (proteolysis-targeting chimeras), allowing for targeted degradation of specific proteins in cellular assays. Its utility spans various research applications, including drug discovery and the study of protein homeostasis and degradation pathways.

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Cat. No.

A81231

CAS No.

2925092-50-6

CRBN ligand-294

CRBN ligand-294 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be utilized in the development of PROTACs (Proteolysis Targeting Chimeras) by linking it to a specific target protein ligand through a suitable linker. Its application in targeted protein degradation offers potential for advancing therapeutic strategies in various diseases.

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Cat. No.

A81232

CAS No.

2925086-04-8

CRBN ligand-668

CRBN ligand-668 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating its recruitment to target proteins. This compound can be conjugated to a specific target protein ligand through a linker, enabling the creation of a PROTAC (proteolysis targeting chimera). CRBN ligand-668 is essential for studies in targeted protein degradation and has potential applications in therapeutic development for various diseases.

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Cat. No.

A81233

CAS No.

2925085-61-4

CRBN ligand-669

CRBN ligand-669 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be effectively utilized in the development of proteolysis-targeting chimeras (PROTACs) by linking it to a target protein ligand via a suitable linker. Its application supports research in targeted protein degradation, offering a promising approach for therapeutic intervention in various diseases.

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Cat. No.

A81234

CAS No.

2925093-34-9

CRBN ligand-692

CRBN ligand-692 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC, enabling targeted protein degradation. Its use is critical in the study of protein turnover and has applications in drug discovery and development for therapeutic interventions.

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Cat. No.

A81235

CAS No.

2925097-56-7

CRBN ligand-737

CRBN ligand-737 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC (proteolysis-targeting chimera). Its strategic design allows for targeted degradation of specific proteins, making it valuable in studies of protein homeostasis and novel therapeutic applications in various diseases.

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Cat. No.

A81236

CAS No.

2925088-76-0

CRBN ligand-364

CRBN ligand-364 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein in cellular contexts. This compound is designed to be conjugated to a target protein ligand through a linker to create a PROTAC (proteolysis-targeting chimera), enabling targeted protein degradation. CRBN ligand-364 is valuable for research in protein regulation and therapeutic applications in cancer and other diseases.

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Cat. No.

A81237

CAS No.

2438238-19-6

Desamino lenalidomide-4-Br-6-acetonitrile

Desamino lenalidomide-4-Br-6-acetonitrile is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of cereblon to target proteins. This compound can be utilized in the development of proteolysis-targeting chimeras (PROTACs) by connecting it to a target protein ligand through a suitable linker. Its application in targeted protein degradation research contributes to innovative therapeutic strategies in oncology and other areas of drug development.

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Cat. No.

A81238

CAS No.

2925075-30-3

CRBN ligand-640

CRBN ligand-640 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to a target protein ligand through a linker, enabling the development of PROTACs (Proteolysis Targeting Chimeras) for targeted protein degradation studies. Its utility in the modulation of protein levels presents valuable applications in drug discovery and therapeutic research.

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Cat. No.

A81239

CAS No.

2925091-91-2

CRBN ligand-257

CRBN ligand-257 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is designed for the development of PROTACs by linking to target protein ligands through a suitable linker, promoting targeted protein degradation. Its application in research is valuable for studying protein turnover and the modulation of cellular pathways.

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Cat. No.

A81240

CAS No.

2925096-29-1

CRBN ligand-344

CRBN Ligand-344 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker, enabling the development of PROTACs (proteolysis targeting chimeras). CRBN Ligand-344 is instrumental in targeted protein degradation research, providing valuable insights into protein regulation and therapeutic strategies.

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Cat. No.

A81241

CAS No.

2925071-25-4

CRBN ligand-770

CRBN ligand-770 is a novel ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. By linking CRBN ligand-770 to a target protein ligand through a suitable linker, researchers can construct proteolysis-targeting chimeras (PROTACs). This compound is valuable for investigating targeted protein degradation pathways and therapeutic strategies in cellular models.

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Cat. No.

A81242

CAS No.

2925099-08-5

CRBN ligand-342

CRBN ligand-342 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of CRBN to target proteins. This compound is designed for use in the development of PROTACs (Proteolysis Targeting Chimeras), enabling the targeted degradation of specific proteins through ubiquitination. Its application in research enhances studies in protein homeostasis and targeted therapy development.

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Cat. No.

A81243

CAS No.

2925095-94-7

CRBN ligand-562

CRBN ligand-562 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling the recruitment of CRBN to target proteins. This compound serves as a crucial component in the design of proteolysis-targeting chimeras (PROTACs) by linking CRBN to specific target protein ligands through a suitable linker. It is useful in studies focused on targeted protein degradation and insights into cellular protein regulation mechanisms.

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Cat. No.

A81244

CAS No.

2925081-22-5

CRBN ligand-374

CRBN ligand-374 serves as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC. It offers a valuable tool for researchers studying protein degradation pathways and therapeutic applications in cellular regulation.

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Cat. No.

A81245

CAS No.

3031608-53-1

CRBN ligand-684

CRBN ligand-684 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, facilitating the formation of a PROTAC (Proteolysis Targeting Chimera). CRBN ligand-684 is invaluable for research in targeted protein degradation and therapeutic interventions in diseases associated with dysregulated protein levels.

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Cat. No.

A81246

CAS No.

2925097-49-8

CRBN ligand-485

CRBN ligand-485 is an E3 ubiquitin ligase cereblon (CRBN) ligand that facilitates the recruitment of the cereblon protein. This compound is utilized in the development of PROTACs (Proteolysis Targeting Chimeras) by linking to target protein ligands through a linker. Its primary application lies in targeted protein degradation research, enabling the modulation of specific protein levels in cellular systems for therapeutic investigations.

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