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E3 ligase ligands bind ubiquitin ligases such as cereblon and von Hippel-Lindau (VHL) in degrader design. In a degrader, they anchor the ligase end of the molecule. E3 ubiquitin ligases transfer ubiquitin to substrate proteins and mark them for degradation by the proteasome. Thalidomide and its analogs bind cereblon (CRBN), a substrate receptor of a cullin-based E3 ligase complex identified as their direct target in 2010. The category includes cereblon ligands such as thalidomide fluoride and TD-106, and VHL ligands such as VL285 and VH032-cyclopropane-F. These ligands are used to build proteolysis-targeting chimeras (PROTACs) and to study how ligases are recruited to new substrates.
CRBN ligand-199 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a Proteolysis Targeting Chimera (PROTAC). It is invaluable for studies involving targeted protein degradation and modulation of cellular pathways.
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CRBN ligand-678 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be utilized in the design and synthesis of PROTACs (proteolysis-targeting chimeras), enabling targeted protein degradation for innovative therapeutic strategies. Its ability to connect to target protein ligands through a linker positions CRBN ligand-678 as a valuable tool in chemical biology and drug discovery research.
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CRBN ligand-496 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be strategically linked to target protein ligands via a linker to create a proteolysis-targeting chimera (PROTAC). Its ability to mediate targeted protein degradation makes it valuable for research applications in drug discovery and functional genomics.
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CRBN ligand-460 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of CRBN, enabling targeted protein degradation through the formation of PROTACs when conjugated with a target protein ligand via a suitable linker. This compound is a valuable tool for research in protein modulation and therapeutic strategies involving targeted protein degradation.
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CRBN ligand-280 is an E3 ubiquitin ligase ligand that specifically targets cereblon (CRBN) to facilitate protein degradation. By recruiting the CRBN protein, this compound can be utilized in the development of PROTACs (proteolysis-targeting chimeras) when linked to a target protein ligand through a suitable linker. Its application in targeted protein degradation research provides a powerful tool for investigating cellular processes and therapeutic interventions.
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CRBN Ligand-312 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be utilized in the design of PROTACs by linking it to other target protein ligands via a suitable linker. Its application in targeted protein degradation studies makes it a valuable tool for investigating cellular pathways and protein regulation.
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CRBN ligand-594 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis targeting chimera). It is instrumental in research applications focusing on targeted protein degradation and the modulation of cellular pathways mediated by CRBN.
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CRBN ligand-338 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to specific target proteins. By utilizing a linker, CRBN ligand-338 can be employed to create PROTACs (proteolysis-targeting chimeras), enabling targeted degradation of intracellular proteins. This compound serves as a valuable tool for research applications in protein homeostasis, targeted protein degradation, and drug discovery.
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CRBN ligand-632 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein in targeted protein degradation applications. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). CRBN ligand-632 serves as a valuable tool for researchers investigating ubiquitin-proteasome pathway mechanisms and developing novel therapeutic strategies in cancer and other diseases.
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CRBN ligand-724 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to synthesize a PROTAC (Proteolysis Targeting Chimera), enabling the selective degradation of specific proteins in cellular assays. Its utility in drug discovery and cellular biology research highlights its relevance in the development of innovative therapeutic strategies.
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CRBN ligand-310 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC, enabling targeted protein degradation. It is valuable for research applications involving ubiquitin-proteasome pathway manipulation and therapeutic development.
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CRBN ligand-315 is an E3 ubiquitin ligase cereblon (CRBN) ligand that facilitates the recruitment of cereblon protein. This compound can be conjugated to a target protein ligand via a linker to create a PROTAC (Proteolysis Targeting Chimera). Its utility in targeted protein degradation makes it a valuable tool for studying protein function and developing potential therapeutics in the field of cellular biology.
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CRBN ligand-319 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be connected to a target protein ligand through a suitable linker to create a proteolysis-targeting chimera (PROTAC), enabling selective degradation of specific proteins. It serves as a valuable tool in the study of targeted protein degradation and has potential applications in drug discovery and therapeutic development.
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Thalidomide-O-amido-C8-NHBoc is a thalidomide analog featuring an amide linkage, an octyl alkyl chain, and a carbamate protecting group. This compound serves as a valuable tool in the exploration of thalidomide's mechanisms of action and its derivatives' biological activity. It is applicable in research related to anti-inflammatory and immunomodulatory effects, aiding in the development of novel therapeutic strategies.
CRBN ligand-227 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of the cereblon protein, enabling targeted protein degradation through PROTAC (Proteolysis Targeting Chimera) technology. This compound is instrumental in research applications focused on elucidating protein turnover and modulating cellular pathways linked to disease.
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E3 ligase Ligand 65 is a specific ligand for E3 ubiquitin ligases, facilitating targeted protein degradation through the ubiquitin-proteasome pathway. It serves as a crucial intermediate in the synthesis of AZ'3137, which is utilized in various research applications, including studies on protein homeostasis and therapeutic development. This compound aids in advancing the understanding of E3 ligase function and its implications in cellular processes.
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CRBN ligand-679 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It effectively recruits CRBN, facilitating targeted protein degradation through the formation of Proteolysis Targeting Chimeras (PROTACs) when linked to a target protein ligand. This compound is valuable in research applications involving protein regulation and therapeutic strategies aimed at disease modulation through selective proteasomal degradation.
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CRBN ligand-387 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). It is a valuable tool in research applications focused on targeted protein degradation and E3 ligase-mediated pathways.
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CRBN ligand-743 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), which facilitates the recruitment of cereblon to target proteins. This compound can be connected to a target protein ligand through a linker, enabling the formation of a proteolysis-targeting chimera (PROTAC). Its key biological activity lies in promoting targeted degradation of specific proteins, making it valuable for research in protein regulation and therapeutic applications.
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5-Fluoro-pomalidomide is an E3 ubiquitin ligase ligand that targets cereblon (CRBN) to facilitate protein degradation. This compound effectively recruits the cereblon protein, making it a valuable tool for the design of PROTACs (Proteolysis Targeting Chimeras) when linked to target protein ligands through a suitable linker. Research applications include studies in targeted protein degradation and the modulation of cellular pathways influenced by CRBN activity.
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CRBN ligand-198 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of the cereblon protein, enabling targeted protein degradation through the PROTAC (proteolysis-targeting chimeras) approach. This compound is valuable for research applications focused on studying protein degradation pathways and developing novel therapeutics that leverage the ubiquitin-proteasome system.
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CRBN ligand-725 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of cereblon to target proteins. This compound can be utilized in the construction of proteolysis-targeting chimeras (PROTACs), allowing for the targeted degradation of specific proteins. Its application is crucial in the study of protein homeostasis and the development of novel therapeutic strategies in various diseases.
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CRBN ligand-527 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN). It effectively recruits the CRBN protein and can be utilized to create a PROTAC by linking it to a target protein ligand through a suitable linker. This compound is valuable for research applications focused on targeted protein degradation and the study of protein turnover mechanisms.
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CRBN ligand-577 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this protein in targeted protein degradation applications. This compound can be conjugated to a target protein ligand through a suitable linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). CRBN ligand-577 supports research in the development of targeted therapies by promoting selective ubiquitination and degradation of specific proteins within the cellular environment.
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Desamino lenalidomide-ethynyl is an E3 ubiquitin ligase cereblon (CRBN) ligand that effectively recruits the cereblon protein. This compound can be conjugated with a target protein ligand through a linker to generate a PROTAC, facilitating targeted protein degradation for research applications. Its unique mechanism of action enables studies in protein homeostasis and therapeutic interventions in cancer and other diseases.
