E3 Ligase Ligands

Cat. No.

A81247

CAS No.

2803460-96-8

5-Hydrazinyl thalidomide hydrochloride

5-Hydrazinyl thalidomide hydrochloride is a thalidomide analog that incorporates a hydrazine moiety, facilitating the development of PROTACs that target E3 ligases for the ubiquitination of specific proteins. This compound serves as a versatile intermediate, offering potential for further derivatization through reactions with a variety of carbonyl groups. Its application in chemical biology research holds promise for advancing therapeutic strategies targeting protein degradation pathways.

Cat. No.

A81248

CAS No.

3036607-80-1

CRBN ligand-108

CRBN ligand-108 is an E3 ubiquitin ligase ligand that targets the cereblon (CRBN) component of the CRL4 E3 ligase complex. This compound facilitates the recruitment of target proteins for ubiquitination and subsequent degradation via the proteasome. CRBN ligand-108 is particularly valuable in the development of PROTACs (proteolysis-targeting chimeras) for targeted protein degradation research applications. Its utility extends to exploring therapeutic strategies in cancer and other diseases by modulating protein levels.

Cat. No.

A81249

CAS No.

2925099-45-0

CRBN ligand-760

CRBN ligand-760 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating its recruitment in cellular processes. This compound is instrumental in the development of proteolysis-targeting chimeras (PROTACs) by conjugating with target protein ligands through a linker. Its application in targeted protein degradation studies provides valuable insights into cellular regulation and therapeutic interventions.

Cat. No.

A81250

CAS No.

2925099-83-6

CRBN ligand-480

CRBN ligand-480 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound serves as a critical component in the development of PROTACs (proteolysis-targeting chimeras), where it can be connected to a target protein ligand through a linker. Its utility in research includes the study of targeted protein degradation and the modulation of cellular signaling pathways.

Cat. No.

A81251

CAS No.

2925091-49-0

CRBN ligand-260

CRBN ligand-260 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be connected to a target protein ligand through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimeras). It is designed for applications in targeted protein degradation research, offering a unique approach to modulate protein levels in various biological contexts.

Cat. No.

A81252

CAS No.

2906183-85-3

(S,R,S)-AHPC-amide-C10-azide

(S,R,S)-AHPC-amide-C10-azide is a potent ligand for the E3 ubiquitin ligase VHL, facilitating the recruitment of the VHL protein. This compound can be conjugated to target protein ligands through a linker, enabling the development of PROTACs for targeted protein degradation studies. Its unique structure and functionality make it a valuable tool for researchers investigating ubiquitin-proteasome pathways and exploring novel therapeutics in cancer and other diseases.

Cat. No.

A81253

CAS No.

3026010-13-6

CRBN ligand-870

CRBN ligand-870 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the CRBN protein. This compound can be utilized in the design of PROTACs (proteolysis-targeting chimeras) by linking it to target protein ligands via a suitable linker. CRBN ligand-870 is instrumental in studying the targeted degradation of specific proteins, contributing to advancements in therapeutic strategies and research in cellular regulation.

Cat. No.

A81254

CAS No.

2925102-47-0

CRBN ligand-550

CRBN ligand-550 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of PROTACs (proteolysis-targeting chimeras). It serves as a valuable tool for studying protein degradation pathways and modulating cellular processes in research applications related to targeted protein degradation.

Cat. No.

A81255

CAS No.

2925085-48-7

CRBN ligand-767

CRBN ligand-767 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is designed for use in the development of proteolysis-targeting chimeras (PROTACs) by linking to target protein ligands through a suitable linker. Its application in drug discovery includes the targeted degradation of specific proteins, enabling innovative approaches to modulate protein activity in various biological studies.

Cat. No.

A81256

CAS No.

2925091-59-2

CRBN ligand-569

CRBN ligand-569 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated with a target protein ligand through a linker to construct a proteolysis-targeting chimera (PROTAC). Its utility in drug discovery includes the potential for targeted protein degradation and modulation of cellular pathways, making it a valuable tool for researchers studying ubiquitin-proteasome system functionalities.

Cat. No.

A81257

CAS No.

2933136-78-6

CRBN ligand-287

CRBN ligand-287 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to specific target proteins. This compound is designed for use in the development of proteolysis-targeting chimeras (PROTACs), enabling targeted degradation of proteins for therapeutic applications. Its ability to effectively modulate protein levels highlights its potential in various biological research and drug discovery endeavors.

Cat. No.

A81259

CAS No.

3026676-91-2

CRBN ligand-232

CRBN ligand-232 is a ligand for the E3 ubiquitin ligase cerberlon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated with a target protein ligand through a linker to produce a PROTAC, enabling targeted protein degradation. Its application is particularly relevant in studies focusing on protein modulation and therapeutic intervention in various disease models.

Cat. No.

A81260

CAS No.

2764746-08-7

(R,R,S)-AHPC

Synonyms: (R,R,S)-VH032-NH2; (R,R,S)-VHL ligand 1

(R,R,S)-AHPC is a ligand for the E3 ligase von Hippel-Lindau (VHL). This compound is designed to recruit the VHL protein, facilitating the degradation of target proteins through the formation of PROTACs (Proteolysis Targeting Chimeras). By linking (R,R,S)-AHPC to specific target protein ligands, researchers can effectively study protein regulation and explore novel therapeutic strategies in cellular pathways.

Cat. No.

A81261

CAS No.

2925088-10-2

CRBN ligand-667

CRBN ligand-667 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this protein for targeted protein degradation. When conjugated with a specific target protein ligand through a linker, CRBN ligand-667 can be utilized to construct a PROTAC, enabling controlled degradation of the target protein. This compound is valuable for research applications focused on protein homeostasis, cellular regulation, and therapeutic development in oncology and other diseases.

Cat. No.

A81262

CAS No.

2925097-33-0

CRBN ligand-292

CRBN ligand-292 is a small-molecule ligand that targets the E3 ubiquitin ligase cereblon (CRBN). It plays a crucial role in the recruitment of CRBN to target proteins, facilitating the formation of PROTACs (Proteolysis Targeting Chimeras). This compound is essential for drug discovery and cellular biology research, particularly in studies focused on targeted protein degradation and the modulation of protein function.

Cat. No.

A81263

CAS No.

2925101-89-7

CRBN ligand-475

CRBN ligand-475 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to target-specific ligands through a linker to create proteolysis-targeting chimeras (PROTACs). CRBN ligand-475 is valuable for investigating targeted protein degradation and enhancing understanding of cellular mechanisms involved in disease pathways.

Cat. No.

A81264

CAS No.

2925093-40-7

CRBN ligand-691

CRBN ligand-691 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN). It plays a crucial role in recruiting the CRBN protein, facilitating its interactions with target proteins. This ligand can be conjugated to a target protein via a linker to create a PROTAC, which supports targeted protein degradation applications in various areas of biological research.

Cat. No.

A81265

CAS No.

2925091-57-0

CRBN ligand-501

CRBN ligand-501 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of the CRBN protein. This compound can be conjugated with target protein ligands through a linker, enabling the formation of proteolysis-targeting chimeras (PROTACs). Its application extends to the selective degradation of target proteins, making it a valuable tool in drug discovery and therapeutic research.

Cat. No.

A81266

CAS No.

2925085-73-8

CRBN ligand-584

CRBN ligand-584 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein for targeted protein degradation. This compound can be conjugated to a target protein ligand through a linker to create a proteolysis-targeting chimera (PROTAC), which enables the selective degradation of specific proteins of interest. It serves as a valuable tool in chemical biology for the study of protein function and the development of innovative therapeutic strategies.

Cat. No.

A81315

CAS No.

2504234-93-7

CRBN ligand-896

CRBN ligand-896 is an E3 ligase ligand utilized in the development of PROTAC (Proteolysis Targeting Chimera) compounds. This reagent facilitates targeted protein degradation by enabling the selective ubiquitination of the epigenetic coactivator p300. It serves as a valuable tool in the investigation of protein regulation and therapeutic strategies in cancer and other diseases associated with dysregulated epigenetic modifiers.

Cat. No.

A81388

CAS No.

2407654-51-5

ZXH-1-161

ZXH-1-161 is a selective modulator of cereblon (CRBN) that induces the degradation of GSPT1 in a CRBN-dependent manner. This compound effectively inhibits the proliferation of multiple myeloma cells and demonstrates significant antitumor activity. Its unique mechanism of action makes it a valuable tool for investigating CRBN-targeted therapies in cancer research.

Cat. No.

B21938

CAS No.

3091503-17-9

Thalidomide-5-F-6-piperidinylpiperazin

Thalidomide-5-F-6-piperidinylpiperazin is a ligand for E3 ligase-linker conjugates and plays a crucial role in the synthesis of PROTAC CDK9 degrader-9. This compound facilitates targeted protein degradation, making it a valuable tool for studies on cellular signaling pathways and protein regulation. Researchers can utilize this reagent to explore therapeutic approaches in cancer and other diseases by modulating the activity of CDK9 and related targets.