Catalog No.
Product Name
Application
Product Information
Citations
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Anti-inflammatory Agent
Mazipredone free base is a glucocorticoid derivative that functions primarily as an anti-inflammatory and anti-allergic agent. It exhibits significant biological activity in reducing inflammation and managing allergic responses. This compound is particularly useful in research applications focused on inflammation-related conditions and therapeutic interventions targeting the immune response. Mazipredone free base is sensitive to oxidation and is affected by both acidic and basic environments. -
Anti-inflammatory agent
Fluocortolone is an orally active anti-inflammatory agent targeting the modulation of inflammatory responses. It is known to effectively reduce plasma fibrinogen levels and demonstrates significant efficacy in alleviating Mycobacterium butyricum-induced foot edema in rat models of adjuvanted joint inflammation, with effective dosing in the range of 3-12 mg/kg. This compound is valuable for studies related to inflammation and joint diseases. -
Anti-inflammatory Agent
Rimexolone is a glucocorticoid steroid that functions primarily as an anti-inflammatory agent. It exhibits potent anti-inflammatory properties and is employed in the management of ocular inflammation. Its formulation as a 1% ophthalmic suspension makes it suitable for targeted treatment in various inflammatory conditions affecting the eye. -
Anti-Inflammatory agent
Fluocortin butyl ester is a topical corticosteroid with anti-inflammatory properties, demonstrating minimal systemic corticosteroid activity upon application. It has shown efficacy and good tolerance in managing symptoms of perennial rhinitis, making it a valuable reagent for research focused on inflammatory responses and related conditions. -
Anti-inflammatory Agent
Prednisolone metazoate sodium is an anti-inflammatory agent primarily used in the study of inflammatory bowel disease, ulcerative colitis, and gastrointestinal disorders. This compound exerts its biological activity by modulating the immune response and reducing inflammation, making it a valuable tool in research focused on inflammatory conditions of the gastrointestinal tract. -
Anti-Inflammatory Agent
Phenyl β-D-glucopyranoside is an anti-inflammatory agent derived from Phellodendron amurense. It exerts its biological activity by inhibiting nitric oxide (NO) production, along with the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Additionally, Phenyl β-D-glucopyranoside prevents the nuclear translocation of nuclear factor kappa B (NF-κB), leading to the reduced expression of pro-inflammatory cytokines and associated genes. This compound is valuable for researchers studying inflammation and related signaling pathways. -
Anti-inflammatory Agent
Fentiazac is an orally active non-steroidal anti-inflammatory agent and alkanoic acid derivative. It exhibits analgesic, antipyretic, and platelet anti-aggregation properties, making it a valuable tool for investigating inflammatory diseases. Research applications include studies related to rheumatoid arthritis, osteoarthritis, and tendinitis. -
Anti-inflammatory Agent
Vedaprofen is a COX-1 selective nonsteroidal anti-inflammatory agent (NSAID) that exerts its effects by inhibiting serum TxB2 and exudate PGE2 production. Additionally, it demonstrates the ability to inhibit the sliding clamp (SC) of Escherichia coli (E. coli) with an IC50 of 222 μM. This dual action makes Vedaprofen valuable for research applications focused on inflammation and bacterial mechanisms. -
Nonsteroidal Anti-inflammatory Agent
Flobufen is a nonsteroidal anti-inflammatory agent that functions primarily as an inhibitor of cyclooxygenase (COX) and 5-lipoxygenase (5-LOX). It has been shown to inhibit alloantigen-driven cellular immune responses while enhancing phagocytosis in peritoneal cells. Flobufen is utilized in research focused on immunopathological disorders and demonstrates potential therapeutic effects in conditions such as rheumatoid arthritis. -
Non-steroidal Anti-inflammatory Agent
Bermoprofen is an orally active non-steroidal anti-inflammatory agent that primarily exerts its effects through inhibition of prostaglandin synthesis. It demonstrates significant antipyretic activity, effectively reducing fever induced by lipopolysaccharides (LPS) in animal models. Due to its rapid onset and short biological half-life, Bermoprofen is applicable in research focused on inflammatory pathways and fever response mechanisms. -
Nonsteroidal anti-inflammatory drug
(R)-Ketoprofen is an orally active nonsteroidal anti-inflammatory drug (NSAID) with potent analgesic properties. It primarily targets cyclooxygenase enzymes to inhibit prostaglandin synthesis, thereby reducing pain and inflammation. (R)-Ketoprofen has been shown to modulate inflammatory cytokine responses, without significantly enhancing the levels of tumor necrosis factor (TNF) and interleukin-1 (IL-1) induced by lipopolysaccharide (LPS). This compound is widely utilized in research applications focused on pain management and inflammatory disease pathways. -
Anti-inflammatory Agent
trans-Isoferulic acid, an aromatic acid and potent anti-inflammatory agent, is derived from the roots of Clematis florida var. plena. It effectively inhibits the production of nitric oxide (NO) and prostaglandin E2 (PGE2) by inducing Nrf2-dependent heme oxygenase-1 (HO-1). This compound is valuable for research applications focused on inflammation pathways and the modulation of oxidative stress. -
Nonsteroidal Anti-Inflammatory Agent
Amtolmetin guacil is a nonsteroidal anti-inflammatory agent that primarily targets cyclooxygenase (COX) to inhibit prostaglandin synthesis. It exhibits significant pain-relieving effects and has the added ability to stimulate capsaicin receptors in the gastrointestinal wall, promoting the release of gastroprotective nitric oxide (NO). This compound is particularly relevant for research focused on knee osteoarthritis and its associated inflammatory processes. -
Anti-Inflammatory Agent
Diftalone, an anti-inflammatory agent, primarily targets inflammatory pathways to modulate immune responses. This compound is utilized in research investigating inflammatory diseases, including rheumatoid arthritis, and offers valuable insights into potential therapeutic approaches for managing such conditions. Its efficacy in reducing inflammation makes it a pivotal tool in the study of chronic inflammatory disorders. -
Antiinflammatory Agent
4-Oxoetodolac, a metabolite of Etodolac, acts as an orally bioavailable anti-inflammatory agent. It effectively inhibits prostaglandin production in cultured chondrocyte cells, contributing to its anti-inflammatory properties. Additionally, 4-Oxoetodolac demonstrates moderate anti-inflammatory activity in a rat adjuvant edema model. This compound is useful for research focused on inflammation and related biological processes. -
Anti-inflammatory Agent
11-Keto-beta-boswellic acid is a pentacyclic triterpenic acid derived from the oleogum resin of the Boswellia serrata tree, commonly known as Indian Frankincense. This compound exhibits significant anti-inflammatory activity through the inhibition of 5-lipoxygenase (5-LOX), which subsequently reduces leukotriene synthesis and attenuates nuclear factor-kappa B (NF-κB) activation, along with the production of tumor necrosis factor alpha. Due to its mechanism of action, 11-Keto-beta-boswellic acid is of interest in studies focused on inflammation-related conditions. -
Anti-inflammatory Agent
Mulberrofuran H is a 2-arylbenzofuran derived from the mulberry tree (Morus lhou (ser.) Koidz.), exhibiting significant anti-inflammatory properties. It effectively inhibits the enzymatic activity of L-tyrosine with an IC50 of 4.45 µM and L-DOPA with an IC50 of 19.70 µM. This compound is of interest in research applications focused on inflammation and oxidative stress, where it demonstrates potent antioxidative activity. -
Anti-inflammatory agent
Pinolenic acid is a polyunsaturated fatty acid derived from the seed oils of Pinus orientalis and Pinus pinaster, primarily recognized for its anti-inflammatory properties. It has demonstrated significant lipid-lowering activities, making it valuable in research related to metabolic disorders and inflammation-related conditions. This compound serves as an important tool for exploring therapeutic interventions aimed at managing inflammatory responses and improving lipid profiles. -
Anti-inflammatory Agent
EA-230 is a synthetic oligopeptide derived from beta-human chorionic gonadotropin (beta-hCG) lysates, serving as an anti-inflammatory agent. It exhibits significant anti-inflammatory properties, making it valuable for research focused on sepsis and related inflammatory conditions. EA-230 is useful in elucidating the mechanisms of inflammation and developing potential therapeutic strategies. -
Antiinflammatory Agent
Ibuprofen alcohol is a nonsteroidal anti-inflammatory agent (NSAID) that primarily functions by inhibiting cyclooxygenase enzymes, leading to a decrease in the synthesis of prostaglandins. It exhibits potent anti-inflammatory activity, making it useful in studies related to pain management and inflammation. This compound serves as a valuable tool in understanding the biochemical pathways involved in inflammatory responses. -
Anti-inflammatory Agent
Salnacedin is an anti-inflammatory agent that exhibits keratolytic activity. It has demonstrated efficacy in reducing inflammation, making it suitable for the study of conditions such as seborrhoeic dermatitis and acne. Researchers can utilize Salnacedin to investigate its therapeutic potential and underlying mechanisms in dermatological disorders. -
Anti-inflammatory/Antioxidant
1-(4-Methoxyphenyl)-1-propanol is an orally active derivative of anethole, primarily exhibiting anti-inflammatory and antioxidant properties. It demonstrates significant antioxidant activity and has been shown to possess anti-inflammatory effects alongside moderate gastric protective activity in mouse models. This compound is useful for studying gastric ulcers and related gastrointestinal conditions in research applications. -
Anti-inflammatory Agent
Phochinenin K is a 9,10-dihydrophenanthrene derivative that demonstrates significant anti-inflammatory activity. Isolated from the rhizomes of Bletilla formosana, this compound is suitable for research applications focused on understanding the mechanisms of inflammatory diseases and developing therapeutic strategies. Its unique properties make it a valuable reagent for studying inflammation-related pathways. -
Antiinflammatory Agent
Aristololactam IIIa functions as an anti-inflammatory agent by effectively inhibiting superoxide anion generation and elastase release, demonstrating IC50 values of 0.12 and 0.20 μg/mL, respectively. This compound is valuable in research applications focused on oxidative stress and inflammatory responses, making it suitable for studying various inflammatory diseases. -
Endogenous Antiinflammatory Mediator
Resolvin E1 (RvE1) is an endogenous anti-inflammatory mediator derived from eicosapentaenoic acid (EPA). It plays a critical role in the resolution of inflammation by inhibiting polymorphonuclear leukocyte (PMN) transendothelial migration and reducing leukocyte infiltration. Additionally, RvE1 suppresses dendritic cell migration and interleukin-12 (IL-12) production, making it a valuable tool for studying inflammatory processes and potential therapeutic interventions in chronic inflammatory diseases. -
Anti-inflammatory Agent
Oxycinchophen functions as an anti-inflammatory agent, demonstrating significant uricosuric activity. It effectively displaces urate from albumin and displays a high affinity for the DNSA-binding site on the albumin molecule. This compound is suitable for research applications focused on inflammation and gout treatment mechanisms. -
Anti-inflammatory Agent
5-Hydroxy-8-methoxypsoralen, a metabolite of Xanthotoxin, functions as a potent anti-inflammatory agent through its inhibition of cytochrome P-450 enzymes. This compound is primarily utilized in the treatment of dermatological conditions such as psoriasis, eczema, and vitiligo, often in conjunction with phototherapy. Its biological activity supports ongoing research in skin inflammation and dermatological therapies. -
Anti-Inflammatory Agent
Desmethyl Ketoprofen is an anti-inflammatory agent that primarily targets pathways involved in inflammation modulation. It exhibits significant anti-inflammatory activities, making it valuable for research in angiogenesis-related disorders and associated pathologies. This compound is essential for studies investigating the effects of inflammation on tissue repair and vascular dynamics. -
Anti-inflammatory Agent
2′-Hydroxydihydrochalcone is an anti-inflammatory agent that exerts its effects through the modulation of inflammatory pathways. This compound is particularly valuable in research investigating mechanisms of inflammation and potential therapeutic applications for inflammatory diseases. It can be synthesized via the reduction of flavone, highlighting its utility in chemical biology studies. -
Anti-inflammatory Agent
6-trans-12-epi-Leukotriene B4, a metabolite of arachidonic acid, functions primarily as an anti-inflammatory agent. Its biological activity is attributed to its role in modulating leukocyte recruitment and activation. This compound is commonly utilized in research applications focused on inflammation, immune response, and related signaling pathways. -
Anti-inflammatory Agent
4-MDM (4-Methoxydiphenylmethane) is an orally active anti-inflammatory agent that selectively enhances the activity of the enzyme leukotriene A4 hydrolase (LTA4H) by promoting its aminopeptidase function. This modulation reduces neutrophil recruitment in the lungs through the improved degradation of proline-glycine-proline, leading to a decrease in inflammation. Importantly, 4-MDM does not influence the epoxy-hydrolase activity of LTA4H. This compound is suitable for studies focusing on lung diseases and related inflammatory conditions. -
Anti-inflammatory Agent, Aminopeptidase Inhibitor
2-(2'-Pyridyl)benzimidazole is an effective anti-inflammatory agent and a potent inhibitor of methionine aminopeptidase in Escherichia coli. This compound exhibits tridentate ligand properties, capable of forming stable complexes with various transition metal ions. Its applications extend to biochemical research focused on inflammatory processes and amino acid metabolism, making it a valuable reagent for studies in these areas. -
Anti-inflammatory Lipid Mediators
5,6-DiHETE is an anti-inflammatory lipid mediator that is synthesized from eicosapentaenoic acid (EPA). It plays a crucial role in mitigating vascular hyperpermeability during inflammatory responses, making it a valuable tool in the study of various inflammatory diseases. Researchers utilize 5,6-DiHETE to explore its therapeutic potential and elucidate the underlying mechanisms of inflammation. -
Anti-inflammatory Agent
Tiaramide is an anti-inflammatory agent that exerts its effects by inhibiting the release of prostaglandin E2 (PGE2). This compound also prevents the increase in intracellular free calcium levels induced by PGE2 and bradykinin, thereby mitigating bradykinin-induced contraction. Tiaramide is valuable for research applications focused on inflammatory pathways and calcium signaling in cellular models. -
Anti-inflammatory Agent
LQFM020 is an orally active pyrazole derivative that functions as an anti-inflammatory agent. It effectively inhibits calcium channels while activating potassium and nitric oxide/cGMP pathways, leading to reduced vasoconstriction. LQFM020 exhibits significant anti-inflammatory and analgesic properties, making it a valuable reagent for research focused on inflammation and pain mechanisms. -
Anti-inflammatory Agent
Trepibutone is an anti-inflammatory agent that enhances the secretion of bile and pancreatic juice while promoting smooth muscle flaccidity in the gastrointestinal tract. This compound serves as a valuable tool in the study of cholecystitis and various functional gastrointestinal disorders, providing insights into digestive health and inflammation-related conditions. -
Anti-inflammatory Agent
Resolvin E2, a proresolving lipid mediator, functions primarily as an anti-inflammatory agent. It plays a crucial role in resolving inflammation and promoting tissue repair through its influence on immune cell activities. This compound is utilized in research applications focused on inflammation resolution, chronic inflammatory diseases, and the modulation of immune responses. -
Anti-inflammatory Agent
LY269415 is a potent anti-inflammatory agent that acts as an inhibitor of iron-dependent lipid peroxidation and 5-lipoxygenase enzyme activity. This compound exhibits significant antioxidant properties, making it valuable for research focused on inflammatory pathways and related diseases. Its oral bioavailability allows for versatile applications in preclinical studies aimed at understanding inflammation-related mechanisms and potential therapeutic interventions. -
Anti-inflammatory Agent
Clidanac is a potent anti-inflammatory agent that acts by uncoupling oxidative phosphorylation. This mechanism contributes to its role in modulating inflammatory responses. Clidanac is primarily applied in research focused on conditions such as rheumatoid arthritis, making it a valuable tool for studying inflammation pathways and potential therapeutic interventions. -
Anti-Inflammatory Peptide
Collagen Type II Fragment is an anti-inflammatory peptide that effectively inhibits collagen-induced arthritis (CIA) in murine models. This fragment serves as a valuable tool for studying inflammation and immune responses, facilitating research aimed at understanding and developing therapies for autoimmune conditions. -
Anti-inflammatory Agent
Linalyl acetate is a phytochemical compound that primarily functions as an anti-inflammatory agent. It exhibits a range of biological activities including anti-anxiety and cardioprotective effects. This compound is useful in research focusing on inflammatory responses and offers potential applications in developing therapeutic agents for related conditions. Linalyl acetate's oral bioactivity further enhances its relevance in pharmacological studies. -
Anti-Inflammatory Agent
3-Aminoisobutyric acid sodium salt acts as an anti-inflammatory agent through its antioxidant properties. It enhances the expression of brown adipocyte-specific genes within white adipose tissue and promotes fatty acid β-oxidation in hepatocytes. This compound has been shown to mitigate insulin resistance and inflammation triggered by palmitate or high-fat diets via an AMPK–PPARδ-dependent pathway in murine models. Additionally, 3-Aminoisobutyric acid sodium salt is a catabolic metabolite of thymine and valine in skeletal muscle. -
Anti-inflammatory Agent
17(R)-Resolvin D1 methyl ester serves as a potent anti-inflammatory agent, derived from Aspirin-induced Resolvin D1. This compound is known to regulate the transendothelial migration of human polymorphonuclear leukocytes, displaying significant efficacy with an EC50 of approximately 30 nM for inhibiting neutrophil migration. Its stability as the 17R-trihydroxy-4Z form enhances its utility in inflammation research and therapeutic applications. -
Non-Steroidal Antiinflammatory Agent
Diflumidone sodium is a non-steroidal anti-inflammatory agent that primarily targets the COX enzyme pathway. This compound exhibits potent anti-inflammatory activity and is utilized in various research applications aimed at understanding inflammatory processes and developing therapeutic strategies for inflammatory diseases. Its ability to modulate inflammation makes it a valuable tool in pharmacological studies and drug development. -
Anti-inflammatory Agent
Tixocortol pivalate is a corticosteroid that functions primarily as an anti-inflammatory agent. It exhibits significant anti-inflammatory properties, making it useful in the research of inflammatory conditions and disorders. This compound is typically employed in studies aimed at understanding the mechanisms of corticosteroids in therapeutic applications. -
Anti-Inflammatory Agent
Paranyline hydrochloride is an anti-inflammatory agent that exhibits topical antiallodynic activity. It is primarily utilized in research exploring pain modulation and inflammation pathways. This compound is valuable for studying the mechanisms underlying chronic pain and developing therapeutic strategies for inflammatory conditions. -
Anti-inflammatory Agent
3-Aminobenzoic acid (3-ABA) is an orally active anti-inflammatory agent that targets tight junction regulatory pathways in intestinal epithelial cells. This compound enhances intestinal barrier integrity and reduces epithelial permeability, thereby improving intestinal inflammation. 3-Aminobenzoic acid is valuable in research focused on gut health, and its analogs can serve as γ-aminobutyric acid transaminase (GABA-AT) inhibitors, demonstrating potential anticonvulsant effects. -
Anti-inflammatory Agent
α-Viniferin is an anti-inflammatory compound derived from the root of Caragana chamlagu. It demonstrates significant potential in modulating inflammatory pathways, making it valuable for research into inflammatory diseases. Its biological activity suggests applications in both pharmacological studies and the development of therapeutic agents targeting inflammation-related conditions. -
Antidiabetic/Anti-inflammatory Agent
9-PAHPA is a fatty acid ester of hydroxy fatty acids (FAHFA) that exhibits significant antidiabetic and anti-inflammatory properties. This compound modulates metabolic processes and inflammation pathways, making it a valuable tool for research in metabolic disorders and chronic inflammatory conditions. Its unique mechanism as an endogenous lipid positions it as a promising candidate for studies focused on therapeutic interventions in diabetes and related inflammatory diseases. -
Anti-Inflammatory reagent
9-OAHSA is a fatty acid ester of hydroxy fatty acids (FAHFAs) known for its anti-inflammatory properties. It exerts its effects by inhibiting cytokine production, notably reducing the expression of IL-1β and IL-6. Additionally, 9-OAHSA functions as a protective agent, preventing apoptotic cell death in colon carcinoma cells, making it a valuable tool for research in inflammation and cancer biology.
