MMP

Cat. No.

A15408

CAS No.

112246-15-8

20(R)-Ginsenoside Rh2

20(R)-Ginsenoside Rh2 is a matrix metalloproteinase (MMP) inhibitor that acts as a cell antiproliferator.

Cat. No.

A15642

CAS No.

29741-09-1

Apigenin-7-glucuronide

Synonyms: Apigenin 7-O-glucuronide

Apigenin-7-glucuronide is a potent inhibitor of Matrix Metalloproteinases (MMP), demonstrating IC50 values of 12.87 µM for MMP-3, 22.39 µM for MMP-8, 17.52 µM for MMP-9, and 0.27 µM for MMP-13. This compound's ability to modulate MMP activity makes it valuable for investigations into extracellular matrix regulation, tissue remodeling, and various inflammatory conditions. Researchers may utilize Apigenin-7-glucuronide in studies aiming to explore therapeutic interventions in diseases associated with MMP dysregulation.

Cat. No.

A15643

CAS No.

29741-10-4

Luteolin 7-O-glucuronide

Synonyms: Luteolin 7-glucuronide

Luteolin 7-O-glucuronide is a potent inhibitor of Matrix Metalloproteinases (MMPs), demonstrating IC50 values of 17.63 μM for MMP-1, 7.99 μM for MMP-3, 11.42 μM for MMP-8, 12.85 μM for MMP-9, and 0.03 μM for MMP-13. This compound is valuable for research investigating the regulation of MMP activity, which plays a critical role in extracellular matrix remodeling and various pathological conditions. It is suitable for applications in studies related to cancer metastasis, tissue repair, and inflammatory disorders.

Cat. No.

A15671

CAS No.

486-21-5

Isofraxidin

Isofraxidin is a coumarin compound derived from *Acanthopanax senticosus* that exhibits anti-invasive and anti-inflammatory properties. It inhibits MMP-7 expression and suppresses cell invasion in human hepatoma cells by reducing ERK1/2 phosphorylation. Isofraxidin also downregulates the expression of iNOS and COX-2 and inhibits the formation of the TLR4/myeloid differentiation protein-2 (MD-2) complex.

Cat. No.

A15945

CAS No.

1762-34-1

Abametapir

Synonyms: HA-44; BRN 0123183; Xeglyze; 6,6'-Bi-3-picoline

Abametapir is the active ingredient of Xeglyze Lotion. Abametapir inhibits metalloproteinases; enzymes that are essential to physiological processes critical for egg development and the survival of nymph and adult lice.

Cat. No.

A16043

CAS No.

497061-48-0

DC_AC50

DC_AC50 is an inhibitor of copper trafficking proteins Atox1 and CCS, resulting in a disruption of cellular copper transport.

Cat. No.

A16519

CAS No.

24390-14-5

Doxycycline hyclate

Synonyms: Doxycycline hydrochloride hemiethanolate hemihydrate; WC2031

Doxycycline hyclate is a broad-spectrum antibiotic and an effective metalloproteinase (MMP) inhibitor. It demonstrates significant antibacterial properties as well as the ability to inhibit cancer cell proliferation. This compound is valuable for constructing models of gene expression regulation in various biological research applications.

Cat. No.

A17025

CAS No.

315705-75-0

JNJ0966

JNJ0966 is a highly selective MMP-9 zymogen inhibitor with an IC50 of 440 nM.

Cat. No.

A17212

CAS No.

287403-39-8

TMI-1

TMI-1 is a novel orally active dual inhibitor of ADAM17 (TACE) and MMP.

Cat. No.

A17240

CAS No.

15866-90-7

Incyclinide

Synonyms: CMT-3; COL3

Iincyclinide, also known as CMT-3 and COL-3, is a MMP inhibitor and a chemically-modified tetracycline with potential antineoplastic activity. Incyclinide inhibits matrix metalloproteinases (MMPs), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. This agent also causes mitochondrial depolarization in tumor cells and induces both cellular apoptosis and tissue necrosis.

Cat. No.

A17545

CAS No.

564-25-0

Doxycycline

Doxycycline, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor.

Cat. No.

A17676

CAS No.

5144-89-8

o-Phenanthroline monohydrate

Synonyms: 1,10-Phenanthroline monohydrate

o-Phenanthroline monohydrate is a potent MMP inhibitor that acts by chelating divalent metal ions, particularly iron (Fe2+), forming a stable red complex that absorbs light maximally at 510 nm. This compound has demonstrated the ability to prevent chromosomal aberrations in cells exposed to streptozotocin, thereby highlighting its significance in cellular and molecular biology research. It is widely utilized in studies investigating metalloproteinases and their role in various biological processes and disease states.

Cat. No.

A17813

CAS No.

17086-28-1

Doxycycline monohydrate

Synonyms: Adoxa; Doxycycline; GS-3065; Monodox; Oracea; Vibramycin

Doxycycline monohydrate is an antibiotic and broad-spectrum metalloproteinase (MMP) inhibitor.

Cat. No.

A18548

CAS No.

544678-85-5

DB04760

DB04760 (compound 4) is a potent, highly selective, non-zinc-chelating MMP-13 inhibitor with an IC50 of 8 nM. DB04760 significantly reduces paclitaxel neurotoxicity and has anticancer activity.

Cat. No.

A18617

CAS No.

960113-85-3

BR351

BR351 is a brain penetrant MMP inhibitor with IC50s of 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13, respectively.

Cat. No.

A19772

CAS No.

145337-55-9

Ro 31-9790

Synonyms: GI4747

Ro 31-9790 is a synthetic metalloproteinase (MMP) inhibitor.

Cat. No.

A20074

CAS No.

203640-27-1

S 3304

S 3304 is a novel matrix metalloproteinases (MMP) inhibitor specific for MMP-2 and MMP-9.

Cat. No.

A20658

CAS No.

960113-89-7

BR351 precursor

Synonyms: BR 351

BR351 precursor is a precursor of BR351. BR351 is a brain penetrant MMP inhibitor with IC50s of 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13, respectively.

Cat. No.

A20763

CAS No.

1224964-36-6

XL-784

XL-784 is a selective matrix metalloproteinases (MMP) inhibitor, with IC50s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1, MMP-2, MMP-3, MMP-8, MMP-9, MMP-13 respectively.

Cat. No.

A20783

CAS No.

341498-89-3

PNU-248686A

PNU-248686A is a novel matrix metalloproteinase (MMP) inhibitor.

Cat. No.

A21501

CAS No.

192329-42-3

Prinomastat

Synonyms: AG3340; KB-R9896

Prinomastat (AG3340) is a broad spectrum, potent, orally active metalloproteinase (MMP) inhibitor with IC50s of 79, 6.3 and 5.0 nM for MMP-1, MMP-3 and MMP-9, respectively.

Cat. No.

A22127

CAS No.

1821370-71-1

PythiDC

PythiDC is a selective inhibitor of collagen prolyl 4-hydroxylase.

Cat. No.

A23206

CAS No.

2848717-49-5

MMP-7-IN-2

MMP-7-IN-2 (comp 16) is a selective MMP7 inhibitor, with an IC50 of 16 nM.

Cat. No.

A23207

CAS No.

2865097-58-9

MMP-7-IN-3

MMP-7-IN-3 is a potent and selective inhibitor of MMP-7. MMP-7-IN-3 suppresses kidney fibrosis progression in a mouse model with unilateral ureteral obstruction.

Cat. No.

A24194

CAS No.

1464910-32-4

JG26

JG26 is a potent ADAM inhibitor with IC50 values of 12 nM for ADAM8, 1.9 nM for ADAM17, and 150 nM for ADAM10. It also inhibits MMP-12 with an IC50 of 9.4 nM. JG26 suppresses AngII-induced EGFR transactivation and ERK activation, upregulates ACE2 expression, inhibits CD23 shedding, and reduces SARS-CoV-2 infection. Additionally, JG26 demonstrates anti-metastatic effects in colorectal cancer and holds research potential in Hodgkin lymphoma and vascular diseases.