MMP

Cat. No.

A76799

CAS No.

204140-01-2

MMP-9/MMP-13 Inhibitor I

MMP-9/MMP-13 Inhibitor I is a highly selective inhibitor targeting matrix metalloproteinases 9 and 13, exhibiting IC50 values of 0.9 nM for both enzymes. This inhibitor demonstrates over 20-fold selectivity for MMP-9 and MMP-13 compared to other matrix metalloproteinases. It is valuable for research into extracellular matrix remodeling, tissue repair, and various pathological conditions including cancer and inflammatory diseases.

Cat. No.

A76800

CAS No.

891198-31-5

RXP470.1

Synonyms: RXP-470

RXP470.1 is a potent and selective inhibitor of matrix metalloproteinase-12 (MMP-12), exhibiting a Ki of 0.2 nM in human MMP-12 assays. This compound demonstrates significantly lower activity against other MMPs, enhancing its specificity. RXP470.1 has been shown to effectively reduce atherosclerotic plaque cross-sectional area in murine models, resulting in improved plaque complexity characterized by an increased smooth muscle cell to macrophage ratio, decreased macrophage apoptosis, enhanced cap thickness, smaller necrotic cores, and reduced calcification incidence. This makes RXP470.1 a valuable tool for studying cardiovascular diseases and related inflammatory conditions.

Cat. No.

A76801

CAS No.

193807-58-8

MMP-2/MMP-9-IN-1

MMP-2/MMP-9-IN-1 is a selective inhibitor targeting MMP-2 and MMP-9, crucial enzymes involved in extracellular matrix degradation. With IC50 values of 0.24 μM for MMP-9 and 0.31 μM for MMP-2, this compound demonstrates potent activity in inhibiting tumor growth and metastasis in preclinical models. MMP-2/MMP-9-IN-1 is a valuable tool for cancer research, facilitating studies on the role of matrix metalloproteinases in tumor progression and invasion.

Cat. No.

A76802

CAS No.

1382722-47-5

MMPI-1154

MMPI-1154 is an imidazole-carboxylic acid (ICA) compound that serves as a potent inhibitor of matrix metalloproteinase-2 (MMP-2), exhibiting an IC50 value of 6.6 μM. This novel reagent also displays inhibitory effects on MMP-13, MMP-1, and MMP-9, with corresponding IC50 values of 1.8 μM, 10 μM, and 13 μM, respectively. MMPI-1154 is valuable for research applications focused on acute myocardial infarction and other conditions associated with matrix remodeling and cardiovascular protection.

Cat. No.

A76803

CAS No.

161314-17-6

NNGH

NNGH is an inhibitor of stromelysin-1 (MMP-3), a matrix metalloproteinase involved in the regulation of the Wnt/β-catenin signaling pathway. By targeting MMP-3, NNGH disrupts crucial processes associated with tumor progression and metastasis. This reagent is valuable for research applications focused on cancer biology, particularly in studies examining the role of matrix metalloproteinases in tumor dynamics and the associated signaling networks.

Cat. No.

A76804

CAS No.

206549-55-5

MMP-9-IN-9

MMP-9-IN-9 is a selective MMP-9 inhibitor that exhibits a potent inhibitory effect with an IC50 of 5 nM. This compound demonstrates a preferential activity for MMP-9, showing minimal interaction with MMP-1 and MMP-13. MMP-9-IN-9 is noted for its strong anti-inflammatory and neuroprotective properties, making it a valuable tool in research focused on inflammation and neurodegenerative diseases.

Cat. No.

A76805

CAS No.

820223-77-6

PF-00356231 hydrochloride

PF-00356231 hydrochloride is a selective inhibitor of matrix metalloproteinase 12 (MMP-12), exhibiting an IC50 of 1.4 µM. It forms a complex with MMP-12, effectively inhibiting its activity, while also demonstrating potency against other matrix metalloproteinases, including MMP-13 (IC50 = 0.00065 µM), MMP-8 (IC50 = 1.7 µM), MMP-9 (IC50 = 0.98 µM), and MMP-3 (IC50 = 0.39 µM). This compound is valuable in research exploring the roles of MMPs in various pathological conditions, including chronic inflammation and tissue remodeling.

Cat. No.

A76806

CAS No.

1025716-81-7

MMP408

MMP408 is a selective inhibitor of matrix metalloproteinase-12 (MMP-12), exhibiting potent activity with IC50 values of 2 nM, 160 nM, and 3 μM for human, mouse, and rat MMP-12, respectively. It also demonstrates an IC50 value of 120 nM against human MMP-13, while showing limited activity against other matrix metalloproteinases. MMP408 has potential applications in researching inflammation, fibrosis, and tissue remodeling, particularly in the context of chronic obstructive pulmonary disease and chronic sinusitis with nasal polyps.

Cat. No.

A76807

CAS No.

2642181-22-2

TP0597850

TP0597850 is a selective inhibitor of matrix metalloproteinase 2 (MMP2), exhibiting an IC50 value of 0.22 nM. This compound demonstrates a prolonged dissociation half-life of 265 minutes, making it an effective tool for studying MMP2's role in various biological processes. TP0597850 is applicable in research focused on cancer metastasis, tissue remodeling, and inflammatory responses.

Cat. No.

A76808

CAS No.

193807-60-2

BPHA

BPHA is a potent, orally active inhibitor of matrix metalloproteinases MMP-2, MMP-9, and MMP-14, exhibiting IC50 values of 12 nM, 16 nM, and 17 nM, respectively. This compound possesses selectivity for these target enzymes, with no significant inhibition observed for MMP-1, -3, and -7. BPHA demonstrates notable antiangiogenic and antitumor activities, making it a valuable tool for cancer research and studies involving tumor microenvironment modulation.

Cat. No.

A76811

CAS No.

2758892-64-5

ADAM8-IN-1

ADAM8-IN-1 is a selective inhibitor of the ADAM8 metalloproteinase, exhibiting an IC50 value of 73 nM. This compound is recognized for its role in modulating extracellular matrix remodeling and inflammatory processes. ADAM8-IN-1 is valuable for research applications focused on cancer biology, autoimmune diseases, and tissue remodeling, facilitating the study of ADAM8's involvement in various pathological conditions.

Cat. No.

A76812

CAS No.

1772-39-0

MMP2-IN-2

MMP2-IN-2 is a potent and selective inhibitor of MMP-2 (matrix metalloproteinase-2), exhibiting an IC50 of 4.2 μM. Additionally, it demonstrates inhibitory activity against MMP-13, MMP-9, and MMP-8, with IC50 values of 12 μM, 23.3 μM, and 25 μM, respectively. This compound is useful in research applications related to tissue remodeling, cancer metastasis, and inflammatory diseases, making it valuable for studies focused on matrix metalloproteinase regulation.

Cat. No.

A76813

CAS No.

1333379-23-9

ND-322 hydrochloride

ND-322 hydrochloride is a potent and selective inhibitor of matrix metalloproteinases (MMPs), specifically targeting gelatinase activity. This compound demonstrates significant biological activity in reducing melanoma tumor growth and effectively delaying metastatic dissemination. ND-322 hydrochloride serves as a valuable tool in cancer research, particularly in studies focused on tumor invasion and metastasis.

Cat. No.

A76815

CAS No.

897799-81-4

MMP2-IN-3

MMP2-IN-3 is a potent inhibitor of matrix metalloproteinase-2 (MMP-2) with an IC50 of 31 μM. This compound also demonstrates inhibitory effects on MMP-9 and MMP-8, presenting IC50 values of 26.6 μM and 32 μM, respectively. MMP2-IN-3 is valuable for research involving extracellular matrix remodeling, inflammation, and cancer progression, making it an important tool for studies focused on metalloproteinase activity modulation.

Cat. No.

A76817

CAS No.

95311-94-7

Lucideric acid A

Lucideric acid A is a natural MMP inhibitor derived from Ganoderma lucidum. It effectively inhibits PMA-induced MMP-9 activity, demonstrating significant anti-invasive effects on hepatoma cells. This compound is useful for research applications focused on cancer metastasis and matrix remodeling.

Cat. No.

A76819

CAS No.

869577-51-5

MMP-2 Inhibitor II

MMP-2 Inhibitor II is a selective inhibitor targeting matrix metalloproteinase-2 (MMP-2). It displays significant inhibitory activity with a potency of 2.4 μM against MMP-2, while exhibiting lower affinity for MMP-1 and MMP-7, at 45 μM and 379 μM, respectively. This compound is valuable for research into the regulation of extracellular matrix remodeling, and its role in various pathological conditions, including cancer metastasis and tissue fibrosis.

Cat. No.

A76821

CAS No.

208663-26-7

MMP12-IN-3

MMP12-IN-3 is a potent inhibitor of matrix metalloproteinase 12 (MMP12), exhibiting an IC50 value of 4.9 nM. This compound is relevant for research into chronic respiratory diseases, particularly emphysema, due to its role in modulating extracellular matrix remodeling and inflammation. Its specificity and efficacy make it a valuable tool for exploring therapeutic strategies targeting MMP12 in pulmonary pathologies.

Cat. No.

A76822

CAS No.

193022-38-7

RS-104966

RS-104966 is a potent inhibitor of matrix metalloproteinase-1 (MMP-1), a key enzyme involved in collagen degradation. It functions by inducing a conformational change in the side chains of the S10 pocket of MMP-1, thereby inhibiting its enzymatic activity. This compound is valuable for studies related to tissue remodeling, inflammation, and various pathological conditions where MMP-1 plays a critical role. Its application extends to research in cancer metastasis, wound healing, and fibrosis.

Cat. No.

A76823

CAS No.

777075-44-2

cis-ACCP

cis-ACCP is a selective inhibitor targeting matrix metalloproteinase-2 (MMP-2), demonstrating potent activity in inhibiting MMP-2 and MMP-9 with IC50 values of 4 μM and 20 μM, respectively. This compound serves as a valuable tool in cancer research, particularly in studies related to antimetastatic therapies and the modulation of extracellular matrix dynamics. cis-ACCP is suitable for investigating the mechanisms underlying various chronic diseases linked to MMP activity.

Cat. No.

A76825

CAS No.

2389060-50-6

Linvemastat

Synonyms: FP-020

Linvemastat is a potent inhibitor of matrix metalloproteinase-12 (MMP-12) with an IC50 value of less than 10 nM, demonstrating high selectivity over MMP-1, -2, -3, -7, -9, -10, and -14. This compound effectively reduces lung fibrosis in a bleomycin-induced unilateral lung fibrosis model and diminishes kidney damage, interstitial inflammation, and fibrosis in a unilateral ureteral occlusion model. Linvemastat is valuable for research into inflammatory diseases, including idiopathic pulmonary fibrosis (IPF), inflammatory bowel disease (IBD), and asthma.

Cat. No.

A76826

CAS No.

95311-96-9

Lucidenic acid C

Lucidenic acid C is a natural compound derived from Ganoderma lucidum, functioning as an inhibitor of matrix metalloproteinases (MMPs). It specifically inhibits PMA-induced MMP-9 activity, demonstrating anti-invasive properties against hepatoma cells. This makes Lucidenic acid C a valuable reagent for research focused on cancer biology and cell invasion mechanisms.

Cat. No.

A76827

CAS No.

459814-89-2

AZD-1236

AZD-1236 is a potent and reversible inhibitor targeting human matrix metalloproteinases MMP-9 and MMP-12. It exhibits significant biological activity in modulating extracellular matrix remodeling and has potential applications in cancer research, inflammatory disorders, and tissue repair studies. This compound serves as a valuable tool for elucidating the role of MMPs in various pathological conditions.

Cat. No.

A76828

CAS No.

226395-93-3

SD-2590 hydrochloride

SD-2590 hydrochloride is a highly potent inhibitor of matrix metalloproteinases (MMPs), exhibiting IC50 values of less than 0.1 nM for MMP2 and MMP13, 0.18 nM for MMP9, and 1.7 nM for MMP8. This compound effectively inhibits the dilation of the left ventricle in rat models, demonstrating its potential for cardiovascular research applications. The selective inhibition of MMPs by SD-2590 can provide valuable insights into various pathological processes, including tissue remodeling and inflammation.

Cat. No.

A76829

CAS No.

2241964-36-1

MMP-9-IN-6

MMP-9-IN-6 is a selective MMP-9 inhibitor with an IC50 value of 50 μM, demonstrating significant potential in modulating matrix metalloproteinase activity. This compound exhibits promising anti-ulcer effects, making it a valuable tool for research into inflammatory diseases and tissue remodeling processes. Its ability to selectively inhibit MMP-9 may contribute to the understanding of its role in various pathophysiological conditions.

Cat. No.

A76831

CAS No.

291533-11-4

PG 116800

Synonyms: PG 530742; PGE 530742; PGE 7113313

PG 116800 is an orally active inhibitor of matrix metalloproteinases (MMPs), exhibiting a high affinity for MMP-2, -3, -8, -9, -13, and -14, while showing significantly lower affinity for MMP-1 and -7. This compound demonstrates notable biological activity in modulating enzymatic processes involved in extracellular matrix degradation. PG 116800 is primarily utilized in research applications related to knee osteoarthritis, providing insights into potential therapeutic strategies for joint-related pathologies.