MMP

Cat. No.

A73546

CAS No.

748120-89-0

SD-7300

Synonyms: SC-81490; PF-02881307

SD-7300 is a potent and selective inhibitor of matrix metalloproteinases (MMP-2, MMP-9, and MMP-13) with Ki values of 0.03, 0.01, and 0.03 nM, respectively. This compound effectively reduces extracellular matrix degradation by tumor cells, thus inhibiting their invasion and metastasis. Additionally, SD-7300 serves as a dose-dependent inhibitor of corneal angiogenesis in mice and mitigates interleukin-1-induced cartilage degradation in bovine models. It is valuable for research applications focused on breast cancer and related studies.

Cat. No.

A73607

CAS No.

220614-50-6

ABT-770

ABT-770 is a selective and orally active inhibitor of matrix metalloproteinase 2 (MMP-2), exhibiting over 1000-fold selectivity with an IC50 of 4 nM compared to MMP-1 (IC50 = 4600 nM). This compound is valuable for research into tumor biology, particularly in studies focused on tumor growth, invasion, and metastasis, providing insights into the role of MMP-2 in cancer progression.

Cat. No.

A73816

CAS No.

108887-68-9

Isozedoarondiol

Isozedoarondiol is a selective inhibitor of matrix metalloproteinase-1 (MMP-1). Found in the rhizomes of Curcuma xanthorrhiza Roxb, this compound effectively reduces MMP-1 expression in UVB-treated human keratinocytes. Isozedoarondiol is valuable for research focused on skin biology, inflammation, and related therapeutic interventions.

Cat. No.

A73869

CAS No.

1025717-75-2

MMP145

MMP145 is a selective and potent inhibitor of matrix metalloproteinase-12 (MMP-12), with oral bioavailability. This compound demonstrates significant anti-inflammatory activity, making it valuable for research in asthma and other inflammation-related conditions. MMP145 is a useful tool for studying the role of MMP-12 in various biological processes and therapeutic interventions.

Cat. No.

A73979

CAS No.

20734-66-1

3-Aminobenzene-1,2-diol

3-Aminobenzene-1,2-diol is a potent inhibitor of matrix metalloproteinases (MMPs), specifically targeting MMP-2, MMP-8, MMP-9, and MMP-14 with IC50 values of 20, 26, 16, and 16.3 μM, respectively. Its selective inhibition of these enzymes highlights its potential in research applications related to tissue remodeling, cancer metastasis, and inflammation. This compound serves as a valuable tool for studying the role of MMPs in various biological processes.

Cat. No.

A74170

CAS No.

140638-26-2

Matlystatin E

Matlystatin E is a selective inhibitor of matrix metalloproteinases (MMPs), which play a crucial role in extracellular matrix remodeling and tissue repair. This compound exhibits significant activity in inhibiting MMP-mediated processes, making it valuable in therapeutic research related to cancer metastasis, fibrosis, and inflammatory diseases. Its use in studies targeting MMP pathways can enhance the understanding of disease progression and treatment efficacy.

Cat. No.

A74185

CAS No.

140667-42-1

Matlystatin F

Matlystatin F is a potent inhibitor of metalloproteinases (MMPs), enzymes that play a critical role in extracellular matrix remodeling. By selectively inhibiting MMP activity, Matlystatin F can contribute to studies focused on cancer metastasis, tissue repair, and inflammatory processes. This compound is essential for researchers investigating the therapeutic potential of modulating MMP activity in various pathological conditions.

Cat. No.

A74283

CAS No.

171347-75-4

GM1489

GM1489 is an MMP inhibitor that effectively reduces degradation at the resin-dentin interface by targeting matrix metalloproteinases (MMPs). This compound enhances bonding stability, making it a valuable tool for investigating methods to improve bonding in both superficial and deep dentin. Its applications extend to studies focused on dental materials and their interaction with dentin substrates.

Cat. No.

A74305

CAS No.

140638-25-1

Matlystatin D

Matlystatin D is a specific inhibitor of matrix metalloproteinases (MMPs), which play a critical role in extracellular matrix remodeling and tissue repair. It demonstrates potent biological activity in inhibiting MMPs, making it a valuable tool in studies related to cancer metastasis, inflammatory diseases, and tissue fibrosis. This compound is useful for research applications focusing on the modulation of extracellular matrix dynamics and the investigation of MMP-related pathways in various biological contexts.

Cat. No.

A74347

CAS No.

206551-25-9

WAY-151693

WAY-151693 is a potent inhibitor of matrix metalloproteinase 13 (MMP13), functioning through a sulfonamide derivative of hydroxamic acid. This compound exhibits significant biological activity, making it a valuable tool for studying the modulation of extracellular matrix remodeling. Its research applications include investigations into tissue repair, cancer progression, and inflammatory diseases, where MMP13 plays a crucial role.

Cat. No.

A74357

CAS No.

769970-91-4

LY52

LY52 is a potent inhibitor of matrix metalloproteinase-2 (MMP-2) and MMP-9, effectively reducing their proteolytic activity. In vitro studies demonstrate that LY52 markedly decreases the expression of MMP-2 and MMP-9 in SKOV3 ovarian cancer cells, leading to inhibited cell invasion. Additionally, in vivo research indicates that LY52 can suppress pulmonary metastasis of Lewis lung carcinoma cells in murine models. This compound serves as a valuable tool in cancer research, particularly in studies focused on the roles of MMPs in tumor progression and metastasis.

Cat. No.

A74500

CAS No.

158018-53-2

4-Epianhydrochlortetracycline hydrochloride

4-Epianhydrochlortetracycline hydrochloride acts as a potent inhibitor of matrix metalloproteinases (MMPs), specifically targeting gelatinase B (Gelatinase B, EC 3.4.24.35). Demonstrating complete inhibition at a concentration of 500 μg/mL, and notable inhibition rates of 70% at 125 μg/mL and 40% at 31 μg/mL, this compound offers significant potential for research into chronic inflammatory diseases. Its efficacy in modulating MMP activity makes it a valuable tool for investigating the underlying mechanisms of tissue remodeling and inflammation.

Cat. No.

A76777

CAS No.

66-71-7

o-Phenanthroline

Synonyms: 1,10-Phenanthroline

o-Phenanthroline is a potent matrix metalloproteinase (MMP) inhibitor that also acts as a metal chelator. It effectively prevents chromosomal aberrations in cells treated with streptozotocin. Within biological systems, o-Phenanthroline forms a stable red chelate with Fe2+, exhibiting peak absorbance at 510 nm. This compound is widely utilized in research applications focusing on metalloprotein interactions and cellular responses to stress.

Cat. No.

A76781

CAS No.

236403-25-1

MMP-8 inhibitor-1

Synonyms: MMP8-I

MMP-8 inhibitor-1 is a potent inhibitor of matrix metalloproteinase-8 (MMP-8), designed to modulate extracellular matrix remodeling. This hydroxamic acid derivative demonstrates significant selectivity for MMP-8, making it a valuable tool for studying the role of this protease in various biological processes and disease models. Its primary applications include research on inflammation, cancer metastasis, and tissue remodeling, providing insights into therapeutic strategies targeting MMP-8 activity.

Cat. No.

A76782

CAS No.

877176-23-3

Aderamastat

Synonyms: FP-025

Aderamastat is a selective inhibitor of MMP-12, providing a targeted approach to modulating extracellular matrix remodeling. This compound demonstrates protective effects against house dust mite-sensitized allergic asthma and is valuable in the study of respiratory diseases, such as chronic inflammatory airway conditions and pulmonary fibrosis. Its selectivity and oral bioavailability make it an important tool for exploring therapeutic interventions in related pathologies.

Cat. No.

A76783

CAS No.

2865097-05-6

MMP-7-IN-1

MMP-7-IN-1 is a selective inhibitor of matrix metalloproteinase-7 (MMP-7) with an IC50 of 10 nM. This compound plays a significant role in inhibiting MMP-7 enzymatic activity, which is implicated in various pathological processes, including tumor progression and fibrosis. MMP-7-IN-1 is valuable for research applications focused on understanding and targeting MMP-7-related diseases.

Cat. No.

A76785

CAS No.

10335-69-0

MMP-2 Inhibitor I

MMP-2 Inhibitor I (OA-Hy) is a potent inhibitor of matrix metalloproteinase-2 (MMP-2) with a Ki value of 1.7 μM. This compound is primarily utilized in research to study the role of MMP-2 in various biological processes, including tissue remodeling and cancer metastasis. Its inhibitory activity makes it a valuable tool for investigating potential therapeutic strategies in diseases where MMP-2 is implicated.

Cat. No.

A76788

CAS No.

1807453-83-3

ND-336

ND-336 is a selective inhibitor of matrix metalloproteinases (MMP)-2, MMP-9, and MMP-14, exhibiting inhibition constants (Kis) of 85, 150, and 120 nM, respectively. This compound has demonstrated significant biological activity in promoting diabetic wound healing in murine models by reducing inflammation and enhancing both angiogenesis and re-epithelialization. ND-336 serves as a valuable tool for research in wound healing, tissue repair, and inflammatory processes.

Cat. No.

A76790

CAS No.

1222173-37-6

BI-4394

Synonyms: MMP13-IN-3

BI-4394 is a potent and selective inhibitor of matrix metalloproteinase-13 (MMP-13), with an IC50 of 1 nM. This orally bioavailable compound exhibits greater than 1000-fold selectivity over other MMPs, making it a valuable tool for investigating the role of MMP-13 in osteoarthritis and related conditions. Its activity offers potential applications in the study of cartilage degradation and therapeutic approaches targeting this specific pathway.

Cat. No.

A76791

CAS No.

935759-55-0

MMP13-IN-2

MMP13-IN-2 is a highly potent and selective inhibitor of matrix metalloproteinase-13 (MMP-13), with an IC50 value of 0.036 nM. Demonstrating over 1,500-fold selectivity for MMP-13 compared to other MMPs such as MMP-1, 3, 7, 8, 9, 14, and TACE, this compound effectively blocks collagen release from cartilage in vitro. MMP13-IN-2 is valuable for research focusing on collagenase-related diseases and investigating the role of MMP-13 in various pathological conditions.

Cat. No.

A76792

CAS No.

203915-59-7

MMP Inhibitor II

MMP Inhibitor II is a potent, reversible pan-MMP inhibitor targeting matrix metalloproteinases (MMPs) with impressive IC50 values of 24 nM, 18.4 nM, 30 nM, and 2.7 nM for MMP-1, MMP-3, MMP-7, and MMP-9, respectively. This compound effectively modulates MMP activity, making it a valuable tool for research in cancer metastasis, tissue remodeling, and inflammatory processes. Its specificity and potency enable detailed studies of MMP-mediated pathways and therapeutic interventions.

Cat. No.

A76793

CAS No.

284667-65-8

RXP03

RXP03 is a potent inhibitor of matrix metalloproteinases (MMPs), exhibiting Ki values of 20 nM for MMP-2, 2.5 nM for MMP-8, 10 nM for MMP-9, 5 nM for MMP-11, and 105 nM for MMP-14. This compound effectively modulates extracellular matrix remodeling and is valuable in studying various pathological conditions such as cancer metastasis and tissue inflammation. RXP03 serves as a crucial tool for researchers investigating MMP-related biological processes and therapeutic interventions.

Cat. No.

A76795

CAS No.

168158-16-5

KB-R7785

KB-R7785 is a selective inhibitor of matrix metalloproteinases (MMPs), known for its ability to enhance insulin sensitivity through the inhibition of TNF-α production. This compound is valuable for research in diabetes and metabolic disorders. Additionally, KB-R7785 demonstrates protective effects against focal cerebral ischemia, making it relevant for studies focused on neuroprotection and ischemic injury.

Cat. No.

A76796

CAS No.

179545-77-8

Tanomastat

Synonyms: BAY 12-9566

Tanomastat is a non-peptidic biphenyl inhibitor of matrix metalloproteinases (MMPs), featuring a Zn-binding carboxyl group that enhances its efficacy. It demonstrates potent inhibition with Ki values of 11 nM for MMP-2, 143 nM for MMP-3, 301 nM for MMP-9, and 1470 nM for MMP-13. Tanomastat exhibits significant anti-invasive and antimetastatic properties in various experimental tumor models, making it a valuable tool for cancer research and therapeutic investigations targeting MMP activity.

Cat. No.

A76797

CAS No.

2865106-78-9

TP0628103 TFA

TP0628103 TFA is a selective inhibitor of matrix metalloproteinase 7 (MMP-7), exhibiting an IC50 value of 0.17 nM. This compound is significant in research related to cancer progression and fibrosis, as it modulates the activity of MMP-7, a key molecule involved in extracellular matrix remodeling. TP0628103 TFA is valuable for studying the therapeutic potential of MMP-7 inhibition in various disease models.