MMP

Cat. No.

A24326

CAS No.

495-02-3

Auraptene

Auraptene is an orally active geranyloxycoumarin compound naturally found in plants of the *Brassicaceae* family. It exhibits a wide range of biological activities, including antibacterial, anti-pathogenic, antioxidant, anti-tumor, and neuroprotective effects. Auraptene has shown therapeutic potential in the management of various chronic conditions such as hypertension and cystic fibrosis, making it a valuable compound for pharmacological and nutraceutical research.

Cat. No.

A24454

CAS No.

502887-71-0

MMP-9-IN-1

MMP-9-IN-1 is a selective inhibitor of matrix metalloproteinase-9 (MMP-9) that specifically targets the hemopexin (PEX) domain of MMP-9, without affecting other MMP family members.

Cat. No.

A24456

CAS No.

380623-76-7

SM-7368

SM-7368 is a potent NF-κB inhibitor that acts downstream of MAPK p38 activation. It suppresses TNF-α-induced upregulation of MMP-9 and is suitable for research on chemotherapeutic strategies targeting TNF-α-mediated tumor invasion and metastasis.

Cat. No.

A25730

CAS No.

2581824-48-6

MMP-9-IN-3

MMP-9-IN-3 is a potent MMP-9 inhibitor, exhibiting an IC50 value of 5.56 nM, and forms hydrogen bonds with the target enzyme. Additionally, it inhibits AKT activity with an IC50 of 2.11 nM. MMP-9-IN-3 demonstrates cytotoxic effects on cells and induces apoptosis, making it valuable for cancer research applications.

Cat. No.

A25774

CAS No.

2581824-80-6

MMP-9-IN-5

MMP-9-IN-5 is a potent MMP-9 inhibitor, with an IC50 of 4.49 nM, that binds to MMP-9 through hydrogen bonding. Additionally, it exhibits inhibition of AKT activity with an IC50 of 1.34 nM. MMP-9-IN-5 demonstrates cytotoxic effects on cells and induces apoptotic processes. This compound is applicable in cancer research, aiding in the exploration of therapeutic strategies targeting tumor progression and metastasis.

Cat. No.

A25811

CAS No.

2581824-39-5

MMP-9-IN-4

MMP-9-IN-4 is a highly potent inhibitor of matrix metalloproteinase 9 (MMP-9), exhibiting an IC50 value of 7.46 nM, and it demonstrates strong H-π interactions with the target. Additionally, MMP-9-IN-4 inhibits AKT activity with an IC50 of 8.82 nM, contributing to its biological profile. This compound displays cytotoxic effects and induces apoptosis in various cell lines, making it a valuable reagent in cancer research applications, particularly in studies focused on tumor progression and metastasis.

Cat. No.

A26246

CAS No.

78285-90-2

Ecliptasaponin A

Ecliptasaponin A is a pentacyclic triterpenoid saponin that functions as a robust inhibitor of matrix metalloproteinases (MMPs). It demonstrates significant anti-tumor properties by activating the ASK1/JNK pathway, leading to apoptosis and autophagy in lung cancer cells. Additionally, Ecliptasaponin A exerts anti-inflammatory and anti-fibrotic effects by inhibiting the HMGB1/TLR4/NF-κB signaling pathway, impacting COX-2 and MMP-9 expression. Its chondroprotective effects are attributed to the downregulation of MMP13 and modulation of inflammatory factors, while it also promotes ovarian function by enhancing ESR1 receptor expression.

Cat. No.

A30588

CAS No.

2764598-01-6

MMP2-IN-1

MMP2-IN-1 is a moderate potency inhibitor of matrix metalloproteinase 2 (MMP2), with an IC50 value of 6.8 µM. This compound displays significant antiproliferative effects on specific cancer cell lines by disrupting cell cycle progression and promoting apoptotic cell death. MMP2-IN-1 is valuable for research applications aimed at investigating the role of MMP2 in cancer biology and developing therapeutic strategies targeting tumor metastasis.

Cat. No.

A30707

CAS No.

1435779-45-5

Prinomastat hydrochloride

Synonyms: AG3340 hydrochloride; KB-R9896 hydrochloride

Prinomastat hydrochloride is a potent, orally active metalloproteinase (MMP) inhibitor that targets various MMPs, demonstrating IC50 values of 79 nM for MMP-1, 6.3 nM for MMP-3, and 5.0 nM for MMP-9. It exhibits high affinity, with Kis of 0.05 nM for MMP-2, 0.3 nM for MMP-3, 0.03 nM for MMP-13, and 0.26 nM for MMP-9, making it a broad-spectrum inhibitor. Notably, Prinomastat hydrochloride is capable of crossing the blood-brain barrier and has demonstrated antitumor activity, making it valuable for cancer research and therapeutic studies targeting MMP-related pathways.

Cat. No.

A31790

CAS No.

2734877-51-9

Tubulin/MMP-IN-2

Tubulin/MMP-IN-2 is a dual inhibitor targeting both tubulin and matrix metalloproteinases (MMPs). It effectively inhibits tubulin polymerization, leading to induced apoptosis in cancer cells. Additionally, Tubulin/MMP-IN-2 demonstrates inhibitory activity against MMP-2, MMP-3, and MMP-9, with IC50 values of 24.95 μM, 31.60 μM, and 22.37 μM, respectively. This compound is valuable for research focused on cancer biology and therapeutic development.

Cat. No.

A31970

CAS No.

3018960-58-9

Anticancer agent 183

Anticancer agent 183 is a potent matrix metalloproteinase-9 (MMP-9) inhibitor that demonstrates over 75% inhibition of MMP-9 activity at a concentration of 100 μg/mL. It exhibits significant anticancer effects with an IC50 value of less than 0.14 μM against the A549 lung cancer cell line. Additionally, Anticancer agent 183 promotes apoptosis, making it a valuable reagent for research in cancer biology and therapeutic applications.

Cat. No.

A39157

CAS No.

488815-65-2

10-Butyl Ether Minocycline

Synonyms: BEM

10-Butyl Ether Minocycline is a derivative of Minocycline that functions as an inhibitor of matrix metalloproteinases MMP-8 and MMP-9, exhibiting IC50 values of 69.4 µM and 47.0 µM, respectively. This compound effectively suppresses lipopolysaccharide-induced microglial activation, inhibits VEGF-induced endothelial cell migration, and reduces L-Glutamine-induced reactive oxygen species levels. Additionally, 10-Butyl Ether Minocycline is shown to significantly decrease alcohol consumption in the Chronic Intermittent Ethanol mouse model of alcohol dependence, making it a valuable reagent for research into neuroimmune-inflammatory diseases and alcohol use disorder.

Cat. No.

A46581

CAS No.

94088-85-4

Doxycycline calcium

Doxycycline calcium is a broad-spectrum antibiotic that serves as a metalloproteinase (MMP) inhibitor. This compound demonstrates antibacterial properties and inhibits cancer cell proliferation, making it valuable in cancer research. Additionally, doxycycline calcium can be utilized in constructing gene expression regulation models, providing insights into gene modulation and environmental response mechanisms.

Cat. No.

A53471

CAS No.

689284-12-6

(R)-TAPI-2

Synonyms: (R)-TNF Protease Inhibitor 2

(R)-TAPI-2 is a potent inhibitor targeting matrix metalloproteinases (MMPs), tumor necrosis factor alpha-converting enzyme (TACE), and a disintegrin and metalloproteinase (ADAM), exhibiting an IC50 value of 20 μM for MMP activity. This compound is utilized in research focused on inflammation, cancer progression, and cell signaling due to its ability to modulate proteolytic processes. Additionally, (R)-TAPI-2 has demonstrated efficacy in preventing viral entry, specifically in the context of SARS-CoV infections, making it valuable for virology studies.

Cat. No.

A57306

CAS No.

1258003-93-8

(R)-MMP408

(R)-MMP408 is a potent inhibitor of matrix metalloproteinase-12 (MMP-12), exhibiting an IC50 of 2.0 nM for human MMP-12. This compound effectively modulates the epithelial-mesenchymal transition (EMT) by upregulating E-cadherin in nasal epithelial cells while simultaneously inhibiting mesenchymal markers such as vimentin, α-smooth muscle actin, and fibronectin, thus reversing the EMT phenotype. (R)-MMP408 is instrumental in research related to airway remodeling diseases, including chronic rhinosinusitis with nasal polyps, chronic obstructive pulmonary disease (COPD), and asthma.

Cat. No.

A57338

CAS No.

259188-38-0

Rebimastat

Synonyms: BMS 275291

Rebimastat is an orally active, broad-spectrum inhibitor of matrix metalloproteinases (MMPs) and a non-peptide collagen mimetic. It exhibits selective inhibition, allowing for modulation of specific MMP activities without affecting all collagenase functions. Rebimastat is utilized in research related to colorectal cancer, providing insights into the role of MMPs in tumor progression and metastasis.

Cat. No.

A63845

CAS No.

57680-56-5

Sucrose octasulfate

Sucrose octasulfate is a matrix metalloproteinase (MMP) inhibitor that modulates cellular activities by regulating the extracellular matrix. It promotes the release of somatostatin-like immunoreactivity from gastric D cells, facilitating ulcer healing through increased endogenous somatostatin levels. This compound has demonstrated efficacy in improving wound closure in diabetic foot ulcers and venous leg ulcers, making it pertinent for research in chronic wound healing and gastrointestinal disorders. Additionally, sucrose octasulfate serves as a valuable pharmaceutical excipient in various therapeutic applications.

Cat. No.

A63873

CAS No.

74135-10-7

Sucrose octasulfate sodium

Sucrose octasulfate sodium is a potent matrix metalloproteinase (MMP) inhibitor that enhances the release of somatostatin-like immunoreactivity (SLI) from gastric D cells. This compound promotes ulcer healing by increasing endogenous gastric somatostatin levels. Sucrose octasulfate sodium is utilized in research related to chronic wound healing and has shown significant efficacy in improving wound closure in diabetic foot ulcers and venous leg ulcers. Additionally, it serves as a useful pharmaceutical excipient in various applications.

Cat. No.

A67124

CAS No.

1176758-04-5

Otaplimastat

Synonyms: SP-8203

Otaplimastat is a matrix metalloproteinase (MMP) inhibitor that effectively suppresses N-methyl-D-aspartate (NMDA) receptor-mediated excitotoxicity through competitive inhibition. In addition to its role as an MMP inhibitor, Otaplimastat displays antioxidant properties. This compound is valuable for research focused on brain ischemic injury and related neuroprotective mechanisms.

Cat. No.

A67291

CAS No.

1176758-02-3

Otaplimastat hydrochloride

Synonyms: SP-8203 hydrochloride

Otaplimastat hydrochloride is a selective inhibitor of matrix metalloproteinases (MMPs), known to mitigate N-methyl-D-aspartate (NMDA) receptor-mediated excitotoxicity through competitive binding. This compound also demonstrates antioxidant properties, making it relevant for studies involving oxidative stress. Otaplimastat hydrochloride is primarily utilized in research related to brain ischemic injury and neuronal protection.

Cat. No.

A71320

CAS No.

158841-76-0

MMP3 inhibitor 3

MMP3 inhibitor 3 is a selective inhibitor targeting matrix metalloproteinase 3 (MMP3). This compound demonstrates significant biological activity in modulating extracellular matrix remodeling and is particularly relevant in the study of breast cancer progression and metastasis. Researchers can utilize MMP3 inhibitor 3 to explore its effects on tumor biology and investigate the therapeutic potential of MMP3 inhibition in cancer treatment.

Cat. No.

A72090

CAS No.

244082-19-7

CTTHWGFTLC, CYCLIC

CTTHWGFTLC, CYCLIC is a cyclic peptide that selectively inhibits matrix metalloproteinases MMP-2 and MMP-9. This compound demonstrates an IC50 value of approximately 8 μM for MMP-9, making it a valuable tool for studying the roles of these enzymes in various biological processes. It is particularly applicable in research focused on cancer metastasis, tissue remodeling, and inflammatory responses.

Cat. No.

A73060

CAS No.

130370-59-1

GI-129471

GI-129471 is a potent matrix metalloproteinase (MMP) inhibitor. It effectively inhibits cancer cell invasion and completely blocks the enhanced production of immunoglobulin E (IgE) and immunoglobulin G1 (IgG1) in mouse B cells induced by rat mast cell protease-I (RMCP-I). This compound is valuable for research focused on cancer biology and mast cell chymase-regulated immunological processes.

Cat. No.

A73362

CAS No.

1664361-37-8

CM-352

CM-352 is a potent inhibitor of matrix metalloproteinases (MMPs), specifically targeting MMP-3 with an IC50 of 15 nM and MMP-10 with an IC50 of 12 nM. This compound exhibits significant antifibrinolytic activity, with an EC50 of 0.7 nM, effectively prolonging blood coagulation time. CM-352 is valuable for research applications focused on anti-bleeding strategies and the modulation of extracellular matrix dynamics.

Cat. No.

A73404

CAS No.

1807453-72-0

ND-378

ND-378 is a potent and selective inhibitor of matrix metalloproteinase-2 (MMP-2), exhibiting a Ki value of 230 nM. It is primarily utilized in research investigating the mechanisms and therapies associated with spinal cord injury (SCI). By inhibiting MMP-2, ND-378 can help elucidate the role of extracellular matrix remodeling in neurological conditions and potential therapeutic strategies.