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$0.00 RIP Kinase
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GSK3145095
Catalog No. A19427 RIP1 kinase inhibitorGSK3145095 is a RIP1 kinase inhibitor with an IC50 of 6.3 nM . Learn More -
Nec-4
Catalog No. A21033 RIP1 inhibitorNec-4, a tricyclic derivative, is a potent receptor interacting protein 1 (RIP1) inhibitor, with an IC50 of 2.6 μM, Ki of 0.46 μM. Learn More -
RIPK1-IN-4
Catalog No. A21029 RIP1 kinase inhibitorRIPK1-IN-4 (compound 8) is a potent and selective type II kinase inhibitor of receptor interacting protein 1 (RIP1) kinase and binds to a DLG-out inactive form of RIP1 with an IC50s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase. Learn More -
WEHI-345
Catalog No. A21012 RIPK2 inhibitorWEHI-345 is a potent and selective RIPK2 kinase inhibitor with an IC50 of 0.13 μM, which delays RIPK2 ubiquitylation and NF-κB activation on oligomerization domain (NOD) stimulation. Learn More -
RIPA-56
Catalog No. A12473 RIP1 inhibitorRIPA-56 is a highly potent, selective, and metabolically stable inhibitor of receptor-interacting protein 1 (RIP1) with an IC50 of 13 nM. Learn More -
RIPK1-IN-7
Catalog No. A18940 RIPK1 inhibitorRIPK1-IN-7 is a potent and selective RIPK1 inhibitor with a Kd of 4 nM and an enzymatic IC50 of 11 nM. RIPK1-IN-7 exhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model. Learn More -
RIPK1-IN-3
Catalog No. A19023 RIPK1 inhibitorRIPK1-IN-3 (Example 38), a RIPK1 inhibitor, extracted from patent WO2018148626A1, possesses anti-inflammatory proprieties. Learn More -
GSK547
Catalog No. A19073 RIP1 inhibitorGSK547 (GSK-547) is a highly selective and potent inhibitor of receptor-interacting serine/threonine protein kinase 1 (RIP1), inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer. Learn More -
GSK2982772
Catalog No. A19380 RIP1 kinase inhibitorGSK2982772 is a potent, orally active and ATP competitive RIP1 kinase inhibitor with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively. Learn More -
Necrostatin-1
Catalog No. A11973 RIPK1 inhibitorNecrostatin-1 is an ATP-competitive, allosteric inhibitor of receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM). Learn More -
GSK-843
Catalog No. A18526 RIPK3 inhibitorGSK-843 (GSK'843) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 8.6 nM, and inhibits kinase activity with an IC50 of 6.5 nM. Learn More -
PK68
Catalog No. A18582 RIPK1 inhibitorPK68 is a potent and selective type II inhibitor of receptor-interacting kinase 1 (RIPK1) with an IC50 of ~90?nM, displays inhibition of RIPK1-dependent necroptosis. Learn More -
HS-1371
Catalog No. A18653 RIP3 inhibitorHS-1371 is a potent and ATP-competitive receptor-interacting protein kinase 3 (RIP3) inhibitor with an IC50 of 20.8?nM. Learn More -
GSK963
Catalog No. A18346 RIP1 kinase inhibitorGSK963 is a chiral, highly potent and selective inhibitor of RIP1 kinase, with an IC50 of 29 nM. GSK963 is a selective and potent inhibitor of necroptosis in murine and human cells in vitro. Learn More -
RIP2 kinase inhibitor 2
Catalog No. A16313 RIP2 kinase inhibitorRIP2 kinase inhibitor 2 is a receptor interacting protein-2 (RIP2) kinase inhibitor extracted from patent WO/2014043437 A1, compound example 9. Learn More -
RIP2 kinase inhibitor 1
Catalog No. A16312 RIP2 kinase inhibitorRIP2 kinase inhibitor 1 is a receptor interacting protein-2 (RIP2) kinase inhibitor extracted from patent WO/2014043446 A1, compound example 1. Learn More -
GSK583
Catalog No. A16311 RIP2 kinase inhibitorGSK583 is a highly potent and selective inhibitor of RIP2 Kinase. Learn More -
GSK481
Catalog No. A12615 RIP1 inhibitorGSK481 is a novel benzoxazepinone (BOAz) series of RIP1 inhibitors. Receptor Interacting Protein Kinase 1 (RIP1) has been implicated as a key contributor to inflammation through the regulation of programmed necrosis. Inhibition of this kinase has been shown to hinder cell necrotic death, thereby establishing RIP1 as a viable target for the potential treatment of multiple inflammatory diseases. Learn More
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