RIP Kinase

18 Item(s)

per page

Set Descending Direction
  1. Necrostatin-1

    Catalog No. A11973
    Quick View
    RIPK1 inhibitor
    Necrostatin-1 is an ATP-competitive, allosteric inhibitor of receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM). Learn More
  2. RIPK1-IN-4

    Catalog No. A21029
    Quick View
    RIP1 kinase inhibitor
    RIPK1-IN-4 (compound 8) is a potent and selective type II kinase inhibitor of receptor interacting protein 1 (RIP1) kinase and binds to a DLG-out inactive form of RIP1 with an IC50s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase. Learn More
  3. WEHI-345

    Catalog No. A21012
    Quick View
    RIPK2 inhibitor
    WEHI-345 is a potent and selective RIPK2 kinase inhibitor with an IC50 of 0.13 μM, which delays RIPK2 ubiquitylation and NF-κB activation on oligomerization domain (NOD) stimulation. Learn More
  4. RIPA-56

    Catalog No. A12473
    Quick View
    RIP1 inhibitor
    RIPA-56 is a highly potent, selective, and metabolically stable inhibitor of receptor-interacting protein 1 (RIP1) with an IC50 of 13 nM. Learn More
  5. RIPK1-IN-7

    Catalog No. A18940
    Quick View
    RIPK1 inhibitor
    RIPK1-IN-7 is a potent and selective RIPK1 inhibitor with a Kd of 4 nM and an enzymatic IC50 of 11 nM. RIPK1-IN-7 exhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model. Learn More
  6. RIPK1-IN-3

    Catalog No. A19023
    Quick View
    RIPK1 inhibitor
    RIPK1-IN-3 (Example 38), a RIPK1 inhibitor, extracted from patent WO2018148626A1, possesses anti-inflammatory proprieties. Learn More
  7. GSK547

    Catalog No. A19073
    Quick View
    RIP1 inhibitor
    GSK547 (GSK-547) is a highly selective and potent inhibitor of receptor-interacting serine/threonine protein kinase 1 (RIP1), inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer. Learn More
  8. GSK2982772

    Catalog No. A19380
    Quick View
    RIP1 kinase inhibitor
    GSK2982772 is a potent, orally active and ATP competitive RIP1 kinase inhibitor with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively. Learn More
  9. GSK3145095

    Catalog No. A19427
    Quick View
    RIP1 kinase inhibitor
    GSK3145095 is a RIP1 kinase inhibitor with an IC50 of 6.3 nM . Learn More
  10. GSK-843

    Catalog No. A18526
    Quick View
    RIPK3 inhibitor
    GSK-843 (GSK'843) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 8.6 nM, and inhibits kinase activity with an IC50 of 6.5 nM. Learn More
  11. PK68

    Catalog No. A18582
    Quick View
    RIPK1 inhibitor
    PK68 is a potent and selective type II inhibitor of receptor-interacting kinase 1 (RIPK1) with an IC50 of ~90?nM, displays inhibition of RIPK1-dependent necroptosis. Learn More
  12. HS-1371

    Catalog No. A18653
    Quick View
    RIP3 inhibitor
    HS-1371 is a potent and ATP-competitive receptor-interacting protein kinase 3 (RIP3) inhibitor with an IC50 of 20.8?nM. Learn More
  13. GSK963

    Catalog No. A18346
    Quick View
    RIP1 kinase inhibitor
    GSK963 is a chiral, highly potent and selective inhibitor of RIP1 kinase, with an IC50 of 29 nM. GSK963 is a selective and potent inhibitor of necroptosis in murine and human cells in vitro. Learn More
  14. RIP2 kinase inhibitor 2

    Catalog No. A16313
    Quick View
    RIP2 kinase inhibitor
    RIP2 kinase inhibitor 2 is a receptor interacting protein-2 (RIP2) kinase inhibitor extracted from patent WO/2014043437 A1, compound example 9. Learn More
  15. RIP2 kinase inhibitor 1

    Catalog No. A16312
    Quick View
    RIP2 kinase inhibitor
    RIP2 kinase inhibitor 1 is a receptor interacting protein-2 (RIP2) kinase inhibitor extracted from patent WO/2014043446 A1, compound example 1. Learn More
  16. GSK583

    Catalog No. A16311
    Quick View
    RIP2 kinase inhibitor
    GSK583 is a highly potent and selective inhibitor of RIP2 Kinase. Learn More
  17. GSK481

    Catalog No. A12615
    Quick View
    RIP1 inhibitor
    GSK481 is a novel benzoxazepinone (BOAz) series of RIP1 inhibitors. Receptor Interacting Protein Kinase 1 (RIP1) has been implicated as a key contributor to inflammation through the regulation of programmed necrosis. Inhibition of this kinase has been shown to hinder cell necrotic death, thereby establishing RIP1 as a viable target for the potential treatment of multiple inflammatory diseases. Learn More
  18. Nec-4

    Catalog No. A21033
    Quick View
    RIP1 inhibitor
    Nec-4, a tricyclic derivative, is a potent receptor interacting protein 1 (RIP1) inhibitor, with an IC50 of 2.6 μM, Ki of 0.46 μM. Learn More

18 Item(s)

per page

Set Descending Direction
Rewards