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Angiotensin Receptors

Angiotensin receptor antagonists block the type 1 and type 2 receptors for the peptide hormone angiotensin II. The angiotensin II type 1 receptor (AT1) mediates vasoconstriction and aldosterone release within the renin-angiotensin-aldosterone system (RAAS). The angiotensin II type 2 receptor (AT2) belongs to a distinct class of seven-transmembrane receptors and is often described as opposing AT1 signaling. Both subtypes were cloned in the early 1990s, AT1 from vascular smooth muscle and AT2 by expression cloning. Most compounds here are nonpeptide AT1 antagonists of the sartan class, such as losartan potassium, candesartan and valsartan. PD 123319 ditrifluoroacetate is a selective AT2 antagonist used to separate the actions of the two subtypes.

3 Items

  • Mitolactol
    Cat. No.
    A58965
    CAS No.
    10318-26-0

    Mitolactol

    Synonyms: NSC 104800

    Mitolactol, an angiotensin receptor activator, exhibits effective inhibition of angiotensin-converting enzyme (ACE) with an IC50 value of 1.4 × 10 M. This compound is known for its ability to suppress the pressor response to angiotensin I when administered intravenously at a dose of 0.3 mg/kg in rat models. Mitolactol is of interest for research focusing on cardiovascular physiology, hypertension, and related therapeutic applications.

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  • AZ11657312
    Cat. No.
    A59013
    CAS No.
    804561-22-6

    AZ11657312

    AZ11657312 is an angiotensin receptor activator that enhances renal medullary perfusion in the context of angiotensin II treatment. This compound significantly improves tissue oxygenation by inhibiting P2X7 receptor activity, particularly in underoxygenated regions of the kidney. AZ11657312 has been shown to increase sodium excretion dramatically, up to sixfold, while also normalizing blood pressure. Its unique mechanism and biological activity make it a valuable tool for studying renal function and hypertension.

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    25 mg
    $1,275.00
    50 mg
    $1,625.00
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  • BRL-36378
    Cat. No.
    A59022
    CAS No.
    84768-09-2

    BRL-36378

    BRL-36378 is an angiotensin receptor activator that modulates the activity of angiotensin-converting enzyme. This compound exhibits significant biological activity, making it valuable for research applications focused on cardiovascular and renal systems. Additionally, BRL-36378 serves as a useful tool in ligand-based virtual screening for the identification of novel lead compounds suitable for chemical optimization.

    In stock View Details
    25 mg
    $1,275.00
    50 mg
    $1,625.00
    All 3 sizes

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