Metabotropic Glutamate Receptors (mGluR)

Cat. No.

A61746

CAS No.

52809-07-1

Quisqualic acid

Synonyms: L-Quisqualic acid

Quisqualic acid is a potent mGluR (metabotropic glutamate receptor) activator derived from the natural source Quisqualis indica. As an excitatory amino acid agonist, it exhibits significant potency with an EC50 of 45 nM and a Ki of 10 nM for mGluR1R. This compound is valuable for research applications involving neurological studies, receptor signaling pathways, and the exploration of excitatory neurotransmission mechanisms.

Cat. No.

A61783

CAS No.

110958-19-5

Fasoracetam

Synonyms: NS 105

Fasoracetam is an activator of metabotropic glutamate receptors (mGluR), playing a significant role in modulating glutamatergic transmission in the central nervous system. This compound demonstrates potential therapeutic applications in the research of attention-deficit hyperactivity disorder (ADHD) and Alzheimer’s disease (AD). Its modulatory effects on synaptic plasticity make it a valuable tool for studying neurological disorders and cognitive enhancement pathways.

Cat. No.

A61890

CAS No.

1030759-58-0

FO-4-15

FO-4-15 is an mGluR1/CaMKIIα activator that demonstrates neuroprotective effects against oxidative stress, specifically H2O2, in human neuroblastoma SH-SY5Y cells. This compound enhances cognitive function in mouse models of Alzheimer’s disease by engaging the mGluR1/CaMKIIα signaling pathway, leading to a reduction in amyloid-beta accumulation, hyperphosphorylated Tau, and synaptic damage. It serves as a valuable tool for investigating mechanisms of neuroprotection and cognitive impairment in neurodegenerative diseases.