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Platelet-Activating Factor (PAF) Receptors

Platelet-activating factor (PAF) receptor antagonists block a G protein-coupled receptor for an inflammatory lipid. PAF is released by platelets, leukocytes and endothelial cells and promotes platelet aggregation, leukocyte activation and vascular permeability. The PAF receptor was cloned by functional expression from guinea pig lung in 1991. Ginkgolide B and ginkgolide A are terpene lactones from Ginkgo biloba that serve as classic natural PAF receptor antagonists. Foropafant, tulopafant and 48740 RP are synthetic antagonists developed for the same receptor. Rupatadine fumarate also blocks the histamine H1 receptor, and CP-96486 also blocks the leukotriene D4 (LTD4) receptor. Further ligands of these receptors are found under Histamine Receptors and Leukotriene Receptor.

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  • 2-O-Ethyl PAF C-16
    Cat. No.
    A62976
    CAS No.
    78858-42-1

    2-O-Ethyl PAF C-16

    2-O-Ethyl PAF C-16 is a homolog of platelet-activating factor (PAF) and acts as a competitive ligand for the platelet-activating factor receptor (PAFR). It exhibits significant inhibition of PAF receptor binding, demonstrated by an IC50 value of 21 nM against the PAF antagonist WEB 2086. This compound is useful for studying PAF-related signaling pathways and the physiological effects mediated by PAFR in various biological research applications.

    In stock View Details
    1 mg
    $65.00
    5 mg
    $125.00
    All 3 sizes

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