GPCR19

Cat. No.

A60412

CAS No.

18866-87-0

5β-Cholestane-3α,7α,12α,25-tetrol

Synonyms: 3α,7α; 12α; 25-Tetrahydroxycoprostane

5β-Cholestane-3α,7α,12α,25-tetrol is a potent TGR5 activator, exhibiting an EC50 of 1.36 μM. This bile acid alcohol plays a significant role in regulating metabolic processes and has shown promising biological activity relevant to energy expenditure and glucose metabolism. Additionally, it serves as a crucial disease marker in Cerebrotendinous xanthomatosis (CTX), making it valuable for research into bile acid signaling and related metabolic disorders.

Cat. No.

A60414

CAS No.

145224-92-6

Deoxycholic acid sodium hydrate

Synonyms: Cholanoic Acid sodium hydrate; Desoxycholic acid sodium hydrate

Deoxycholic acid sodium hydrate is a bile acid that functions as an activator of the G protein-coupled bile acid receptor TGR5. It plays a significant role in lipid metabolism and has been implicated in various physiological processes, including glucose homeostasis and energy expenditure. This compound is commonly used in research applications focused on metabolic disorders, liver function, and signaling pathways influenced by bile acids.

Cat. No.

A60416

CAS No.

647011-80-1

6ECA

6ECA is a selective activator of the TGR5 receptor, exhibiting an EC50 of 3.44 μM. This compound demonstrates no significant activity at the FXR, making it a useful tool for investigating the role of TGR5 in metabolic conditions. 6ECA is particularly applicable for research focused on diabesity and related disorders.